Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Viruses ; 16(7)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-39066228

RESUMO

Acute respiratory tract infections, including influenza A (FluA), respiratory syncytial virus (RSV) infection, and COVID-19, can aggravate to levels requiring hospitalization, increasing morbidity and mortality. Identifying biomarkers for an accurate diagnosis and prognosis of these infections is a clinical need. We performed a cross-sectional study aimed to investigate the changes in circulating levels of arachidonic acid, interleukin 6 (IL-6), and C-reactive protein (CRP) in patients with FluA, RSV, or COVID-19, and to analyze the potential of these parameters as diagnosis or prognosis biomarkers. We analyzed serum samples from 172 FluA, 80 RSV, and 217 COVID-19 patients, and 104 healthy volunteers. Individuals with lung viral diseases showed reduced arachidonic acid concentrations compared to healthy people, with these differences being most pronounced in the order COVID-19 > RSV > FluA. Conversely, IL-6 and CRP levels were elevated across diseases, with IL-6 emerging as the most promising diagnostic biomarker, with areas under the curve (AUC) of the receiver operating characteristics plot higher than 0.85 and surpassing arachidonic acid and CRP. Moreover, IL-6 displayed notable efficacy in distinguishing between FluA patients who survived and those who did not (AUC = 0.80). These findings may provide useful tools for diagnosing and monitoring the severity of acute viral respiratory tract infections, ultimately improving patient outcomes.


Assuntos
Ácido Araquidônico , Biomarcadores , Proteína C-Reativa , COVID-19 , Influenza Humana , Interleucina-6 , Infecções por Vírus Respiratório Sincicial , Humanos , Ácido Araquidônico/sangue , Proteína C-Reativa/análise , COVID-19/sangue , COVID-19/diagnóstico , Influenza Humana/sangue , Influenza Humana/diagnóstico , Influenza Humana/virologia , Interleucina-6/sangue , Infecções por Vírus Respiratório Sincicial/sangue , Infecções por Vírus Respiratório Sincicial/diagnóstico , Masculino , Feminino , Pessoa de Meia-Idade , Biomarcadores/sangue , Estudos Transversais , Adulto , Idoso , SARS-CoV-2 , Vírus da Influenza A , Adulto Jovem , Curva ROC
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...