RESUMO
Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.
Assuntos
Anti-Inflamatórios/uso terapêutico , Ayurveda , Ácido Acético/uso terapêutico , Aloe/uso terapêutico , Animais , Combinação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Feminino , Masculino , Fitoterapia , Plantas Medicinais , RatosRESUMO
Brahmi Rasayan, an Ayurvedic preparation, was studied in rodents for its antiinflammatory effects at po doses ranging between 1 and 10 g/kg. The drug suppressed various experimentally induced inflammatory reactions and did not show any gastric irritation in antiinflammatory doses. It is suggested that it may partially mediate its antiinflammatory activity by interfering with the action and/or synthesis of prostaglandins and also perhaps by stabilization of the lysosomal membranes. Its antiinflammatory activity is comparable to that of indomethacin.
Assuntos
Anti-Inflamatórios/farmacologia , Ayurveda , Animais , Feminino , Masculino , RatosRESUMO
Clonidine, a potent centrally acting antihypertensive drug was screened for effect on " free " and " bound " acetylcholine (Ach) in brain of morphine dependent and morphine withdrawal rats, anticonvulsant activity and morphine withdrawal rats, anticonvulsant activity and local anaesthetic activity. " Free " and " total " Ach content in normal (non-dependent) animals as well as in animals dependent to morphine was not changed by clonidine. Naloxone produced abstinence syndrome in dependant rats with highly significant increase in " free " Ach. Clonidine pretreatment decreased the rise of " free " Ach content produced by naloxone. It failed to show any anticonvulsant effect against maximal electroshock convulsions in rats, however, it exhibited significant local anaesthetic activity. Diuresis, piloerection and convulsions were observed with higher doses of clonidine.
RESUMO
Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.
Assuntos
Aminoácidos/farmacologia , Anti-Inflamatórios não Esteroides , Aminoácidos/toxicidade , Animais , Carragenina , Diarreia/prevenção & controle , Edema/tratamento farmacológico , Feminino , Granuloma/tratamento farmacológico , Masculino , Fenilbutazona/farmacologia , RatosAssuntos
Arritmias Cardíacas/tratamento farmacológico , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Metiamida/uso terapêutico , Tioureia/análogos & derivados , Animais , Depressão Química , Cães , Avaliação de Medicamentos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Masculino , Metiamida/farmacologiaRESUMO
An improvised, yet simple technique for the evaluation of drugs affecting voluntary activity is described with certain modifications and incorporation of common instruments. The technique imparts semi quantitative information which is lacking in the many described in the literature.
Assuntos
Biofísica/métodos , Atividade Motora , Farmacologia/métodos , Animais , Feminino , Masculino , RatosRESUMO
Quinidine, propranolol and their combination were studied in atrial fibrillation induced by the topical application of acetylcholine or aconitine, injury-stimulation-induced atrial flutter and ventricular ectopic tachycardia produced by coronary occlusion in the dog. The effect of combination of quinidine and propranolol was significantly greater than that of the individual drug in atrial arrhythmias but not in ventricular arrhythmias. The study provides experimental support for the combined clinical use of quinidine and propranolol in the treatment of atrial arrhythmias.
