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1.
Curr Med Sci ; 42(3): 597-605, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35648284

RESUMO

OBJECTIVE: The present study aimed to develop an autophagy-related gene prognostic prediction model to provide survival risk prediction for head and neck squamous cell carcinoma (HNSCC) patients. METHODS: The K-mean cluster analysis was performed on HNSCC samples based on the expression values of 210 autophagy-related genes for candidate signature gene selection. LASSO Cox regression analysis was generated using the potential genes and the risk score was calculated from the prognosis model. The risk score was processed as an independent prognostic indicator to construct the nomogram model. The immune status including immune cell infiltration ratio and checkpoints of patients with HNSCC in high- and low-risk groups was also explored. RESULTS: LASSO Cox regression analysis was performed on the selected autophagy-related genes. According to the lambda value corresponding to the number of different genes in the LASSO Cox analysis, six genes (GABARAPL2, SAR1A, ST13, GAPDH, FADD and LAMP1) were finally chosen. The risk score based on the genes was generated, which was an independent prognostic marker for HNSCC. The prognostic prediction model (nomogram) was further optimized by the independent prognostic factors (risk score), which can better predict the prognosis and survival of patients. With the risk score and prognosis model, eight types of immune cells and six key immune checkpoints (CTLA4, PD1, IDO1, TDO2, LAG3, TIGIT) displayed expression specificity. CONCLUSION: This study identified several potential prognostic biomarkers and established an autophagy-related prognostic prediction model for HNSCC, which provides a valuable reference for future clinical research.


Assuntos
Neoplasias de Cabeça e Pescoço , Autofagia/genética , Análise por Conglomerados , Neoplasias de Cabeça e Pescoço/genética , Humanos , Prognóstico , Carcinoma de Células Escamosas de Cabeça e Pescoço/genética
2.
Artigo em Inglês | MEDLINE | ID: mdl-34886469

RESUMO

BACKGROUND: Economic growth in China has brought about significant social and psychological changes in society. OBJECTIVE: This study aims to explore how the mental and psychological health of college students has changed over the past decade. METHODS: We observed several cohort samples in a Chinese university over a decade and looked at five mental health outcomes, including suicidal ideation, depression, optimism, self-esteem, and perceived social support, throughout each year of testing. RESULTS: Our study highlights the declining rates of suicidal ideation and depression, combined with relative stability and even small increases in optimism, self-esteem, and perceived social support across a range of demographic variables. CONCLUSIONS: The findings of this study imply that in the context of economic growth, stabilizing and improving positive mental health states can help prevent and reduce the risk of depression and suicidal ideation among college students. The study also highlighted the need for more public health campaigns and interventions in universities to help students cope with mental health problems.


Assuntos
Estudantes , Universidades , China/epidemiologia , Humanos , Avaliação de Resultados em Cuidados de Saúde , Ideação Suicida
3.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 30(5): 539-43, 2012 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-23173324

RESUMO

OBJECTIVE: To examine the flora samples from the tongue dorsum of the atrophic glossitis group and to discuss the relationship so as to provide a thinking pattern for therapy and a clue for deeper research. METHODS: To collect personal information on 60 cases of atrophic glossitis and 40 cases of volunteers as control. The main items include general status, oral examination, salivary flow rate, pH value and bacteria test. All data were analyzed statistically. RESULTS: 1) Among the 60 cases, 75.00% were female patients. Glosso-pain, dry mouth and taste loss were the most common symptoms. 2) In regard to the pathogenic factors, the systematic diseases were often visible, i.e. gastritis, coronary disease and anemia. 3) Oral hygiene of the patients was worse than that of the control group, the saliva flow rate and pH value were lower than that of the control. 4)The statistic analysis showed that the quantity of some bacteria of tongue dorsum and their detectable rate were different between the glossitis group and the control one, between the patients with atrophic glossitis who also suffered from different systematic diseases and the control group, and between the complete type and the partial type. These bacteria included Streptococcus sanguis, Stomatococcus, Staphylococcus aureus, Saccharomyces, etc. CONCLUSION: Atrophic glossitis is the consequence co-affected by host, circumstances of oral cavity and bacteria. The tangible relationship between atrophic glossitis and micro-ecological changes on glossal dorsum has not been confirmed yet, however, flora change on dorsum may have relations with occurrence, and development of the disease.


Assuntos
Glossite , Staphylococcus aureus , Idoso , Atrofia , Feminino , Humanos , Masculino , Língua
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