Chitosan-alginate sponge with multiple cross-linking networks for adsorption of anionic dyes: Preparation, property evaluation, mechanism exploration, and application.

A chitosan-alginate sponge (CAS) with multiple cross-linking networks was developed using chitosan, sodium alginate, polyvinyl alcohol, and glutaraldehyde to adsorb and enrich the anionic dyes form the food samples. The multiple networks in CAS refer to the electrostatic cross-linking network, hydrogen bonding cross-linking network, and covalent cross-linking network. Compared with pure chitosan and alginate sponges, the CAS showed better three-dimensional network structure, mechanical behavior, and stability, which is benefit by multiple cross-linking networks. The physical and chemical properties of CAS were systematically studied by a series of characterizations. The adsorption performance of CAS on anionic dyes was inspected with different dye concentration, time, temperature, and pH conditions. CAS exhibited a good and stable adsorption property to amaranth, carmine, and sunset yellow with the saturation adsorption capacity of 94.34, 111.5, and 80.05 mg∙g-1, respectively. Furthermore, CAS performed outstanding selectivity to anionic dyes with the selectivity factor up to 16.99. Through electrostatic potential analysis, it is inferred that CAS mainly adsorbs anionic dyes through electrostatic interactions. CAS showed satisfactory reusability, maintaining 97 %-99 % of adsorption performance after six cycles of recycling. Finally, CAS was combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples, achieving the enrichment factor up to 84.77.

Antibiotic-loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: A meta-analysis.

In recent years, local antibiotic-loaded bone substitutes (ALBS) have been used increasingly in the treatment of diabetic foot infection (DFI). The meta-analysis aimed to analyse the efficacy of ALBS on patients with moderate to severe DFI (with or without osteomyelitis). With an appropriate search strategy, 7 studies were selected for analysis (2 RCTs and 5 cohort studies). The result showed that the application of ALBS effectively reduced the length of hospital stay (WMD -5.55; 95% CI: -9.85 to -1.26; P = 0.01), the recurrence rates (RR 0.33; 95% CI: 0.15 to 0.69; P = 0.003) and the mortality rates (RR 0.22; 95% CI: 0.06 to 0.82; P = 0.02). Compared to the control groups, however, there was no difference in healing rates (RR 1.06; 95% CI: 0.96 to 1.18; P = 0.26), healing time (WMD -1.44; 95% CI: -3.37 to -0.49; P = 0.14), the number of debridement (WMD -1.98; 95% CI: -4.08 to 0.12; P = 0.06) and major amputation rates (RR 0.76; 95% CI: 0.35 to 1.61; P = 0.47). The ALBS appears to have some beneficial effects as an adjunct to standard surgery in the treatment of DFI with or without osteomyelitis, as it reduces recurrence rates, mortality rates, and length of hospital stay, but there was no statistically significant difference in enhancing wound healing.

Two-dimensional Thouless pumping of light in photonic moiré lattices.

Continuous and quantized transports are profoundly different. The latter is determined by the global rather than local properties of a system, it exhibits unique topological features, and its ubiquitous nature causes its occurrence in many areas of science. Here we report the first observation of fully-two-dimensional Thouless pumping of light by bulk modes in a purpose-designed tilted moiré lattices imprinted in a photorefractive crystal. Pumping in such unconfined system occurs due to the longitudinal adiabatic and periodic modulation of the refractive index. The topological nature of this phenomenon manifests itself in the magnitude and direction of shift of the beam center-of-mass averaged over one pumping cycle. Our experimental results are supported by systematic numerical simulations in the frames of the continuous Schrödinger equation governing propagation of probe light beam in optically-induced photorefractive moiré lattice. Our system affords a powerful platform for the exploration of topological pumping in tunable commensurate and incommensurate geometries.