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1.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-911641

RESUMO

Objective:To explore risk factors for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adult Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (Ph-ALL).Methods:A retrospective analysis was performed for 65 adult Ph-ALL patients undergoing initial allo-HSCT from 2016 to 2018. The effect of baseline level and treatment pre-transplantation for relapse after allo-HSCT was analyzed.Results:There were 37 males and 28 females with a median age of 25(14-58) years during allo-HSCT. And the median follow-up period was 27 months post-HSCT. The 2-year overall survival (OS) was 78.8%(95%CI 67.8%-89.8%) and the 2-year relapse-free survival (RFS) 70.7% (95%CI 58.2%-83.2%). Pre-transplant chemotherapy was offered for 3 to 7 courses and the median dose of polyethylene glycol-conjugated asparaginase (PEG-ASP) was 3 doses (2 000 IU/m 2 per dose). Multiariate analysis revealed that the regimen included more than 4 doses of PEG-ASP pre-HSCT (HR=4.067, P=0.046) was a protective factor for post-transplant relapse (HR=0.193, P=0.009). High-risk chromosome karyotype was a risk factor for relapse (HR=0.193, P=0.009). The 2-year RFS rate was 90.0%(95%CI 79.2%-100.0%) for intensive PEG-ASP group and 56.9%(95%CI 39.1%-74.7%) for control group ( P=0.01). No significant inter-group difference existed in overall survival (OS)( P=0.079). The 2-year OS was 90.6% (95%CI 80.4%-100.0%) in intensive PEG-ASP group and 72.1% (95%CI 56.6%-87.6%) in control group. Conclusions:For adult ph-ALL patients, a higher dose of PEG-ASP in pretransplant chemotherapy regimens may improve post-transplant RFS and achieve a better outcome.

2.
China Pharmacy ; (12): 2347-2353, 2021.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-886915

RESUMO

OBJECTIVE:To study the effects of Cu rcumin solid lipid n anoparticels (Cur-SLN) on cardiac ,renal and pulmonary functions ,the expression of autophagy related factors in cardiorenal syndrome model rats. METHODS :The rats were divided into sham operation group ,model group ,rapamycin group (positive control ,2 mg/kg),Cur-SLN low-dose and high-dose groups(5,10 mg/kg),except for 13 rats in the model group (3 of which are used to judge whether modeling is successful ),10 rats in the other groups. Except for sham operation group ,cardiorenal syndrome of other groups were induced by abdominal aortic coarctation combined with acute renal ischemia-reperfusion injury. After successful modeling ,rats in each administration group were injected with corresponding drugs through caudal vein ,and rats in sham operation group and model group were injected with equal volume normal saline ,once a day for 4 weeks. Twenty-four hours after the last administration ,the contents of angiotensin converting enzyme (ACE),free triiodothyronine (FT3) and arginine vasopressin (AVP) in rat serum were detected. The pathological morphology of rat heart ,kidney and lung were observed. The distribution and expression of LC 3 and Beclin- 1 protein in rat heart ,kidney and lung were detected. RESULTS :Compared with sham operation group ,the contents of ACE and FT 3 in serum,the indexes of heart and kidney ,the expression of LC 3(except in renal tissue )and Beclin- 1 protein in heart ,kidney and lung were significantly increased (P<0.01),and the contents of AVP and lung index were decreased significantly (P<0.01); myocardial cells in the non-infarcted area of the heart were obviously hypertrophic ,the arrangement of myocardial fibers was disordered ; the structure of renal tubules in the non-infarcted area of the kidney was disordered ;and there was cystic expansion and obvious inflammatory cell infiltration llittls- in the alveoli ;positive expression of LC 3 and Beclin- 1 protein nows@126.com in heart ,kidney and lung increased ,mainly distributed in the cytoplasm of cardiomyocytes ,distal renal tubular epithelial cells ,alveolar macrophages and epithelial cells. Compared with model group,the above indexes of rats in each dose group of Cur-SLN were mostly significantly reversed ;the pathological changes of heart,kidney and lung tissues were reduced ,the infiltration of inflammatory cells was reduced ;and the positive expression of LC 3 and Beclin- 1 protein were reduced ,which were mainly distributed in the cytoplasm of cardiomyocytes and proximal renal tubular epithelial cells ,and a few in distal renal tubular epithelial cells ,alveolar macrophages and epithelial cells. CONCLUSIONS : Cur-SLN can improve the heart ,kidney and lung functions of rats with cardiorenal syndrome ,and its mechanism may be related to regulating the distribution or expression of LC 3 and Beclin- 1 protein in heart ,kidney and lung.

3.
Pharmacogenomics ; 19(4): 343-348, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29469608

RESUMO

Acute myeloid leukemia (AML) is a heterogeneous malignant disease. Many different genetic factors can affect a patient's clinical outcome. AIM: The aim of this study was to assess the expression of BCL11A and MDR1 in AML patients, and its relation to clinical outcome. MATERIALS & METHODS: We grouped the 142 patients by the levels of BCL11A and MDR1 and identified three different subgroups: high BCL11A and high MDR1 (n = 47), low BCL11A and low MDR1 (n = 47) and high BCL11A alone or high MDR1 alone (n = 48). RESULTS: The results showed that AML patients with high BCL11A and MDR1 expression had the lowest complete remission and highest relapse rate. The median overall survival of the high BCL11A and high MDR1 group was the shortest among the three groups. With regards to overall survival, there were also significant differences among the groups (p < 0.001). CONCLUSION: High BCL11A and MDR1 expression was associated with a poor response to chemotherapy, and identified a subset of AML patients with a very poor prognosis.


Assuntos
Proteínas de Transporte/genética , Leucemia Mieloide Aguda/genética , Leucemia Mieloide Aguda/patologia , Proteínas Nucleares/genética , Subfamília B de Transportador de Cassetes de Ligação de ATP/genética , Adulto , Antineoplásicos/uso terapêutico , Feminino , Humanos , Leucemia Mieloide Aguda/tratamento farmacológico , Masculino , Prognóstico , Indução de Remissão/métodos , Proteínas Repressoras
4.
Artigo em Inglês | MEDLINE | ID: mdl-25570354

RESUMO

Low dose positron emission tomography(PET) reconstruction remains a challenging issue for statistical PET reconstruction methods due to the low SNR of data. Due to the ill-conditioning of image reconstruction, proper prior knowledge should be incorporated to constrain the reconstruction. Since PET images are piecewise smoothing, we propose the total variational (TV) minimization based algorithm for low dose PET imaging. The fundamental power of this strategy rests with the edge locations of important image features tend to be preserved thanks to TV regularization. In addition, a new computational method have been employed with improved computational speed and robustness. Experimental results on Monte Carlo simulations demonstrate its superior performance.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Tomografia por Emissão de Pósitrons/métodos , Algoritmos , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Simulação por Computador , Humanos , Modelos Estatísticos , Método de Monte Carlo , Imagens de Fantasmas , Fótons , Reprodutibilidade dos Testes , Razão Sinal-Ruído
5.
Med Image Comput Comput Assist Interv ; 14(Pt 2): 242-50, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21995035

RESUMO

Spurious temporal drift is abundant in fMRI data, and its removal is a critical preprocessing step in fMRI data assimilation due to the sparse nature and the complexity of the data. Conventional data-driven approaches rest upon specific assumptions of the drift structure and signal statistics, and may lead to inaccurate results. In this paper we present an approach to the assimilation of nonlinear hemodynamic system, with special attention on drift. By treating the drift variation as a random-walk process, the assimilation problem was translated into the identification of a nonlinear system in the presence of time varying bias. We developed two-stage unscented Kalman filter (UKF) to efficiently handle this problem. In this framework the assimilation can implement with original fMRI data without detrending preprocessing. The fMRI responses and drift were estimated simultaneously in an assimilation cycle. The efficacy of this approach is demonstrated in synthetic and real fMRI experiments. Results show that the joint estimation strategy produces more accurate estimation of physiological states, fMRI response and drift than separate processing due to no assumption of structure of the drift that is not available in fMRI data.


Assuntos
Mapeamento Encefálico/métodos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Algoritmos , Encéfalo/patologia , Gráficos por Computador , Hemodinâmica , Humanos , Modelos Estatísticos , Análise de Regressão , Processamento de Sinais Assistido por Computador , Software , Fatores de Tempo
6.
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-380261

RESUMO

Objective To study the relationship between the MDR1 gene expressions and CD56 antigen expression in patients with de novo acute myeloid leukemia(AML) and to explore the role of this two factors in clinical drug resistance and their correlation. Methods A real-time quantitative RT-PCR method was established for detecting MDR1 expression levels and three-color flow cytometry analysis using CD34/ SSC gating was used to examined CD56 antigen expression in 79 de novo AML patients. Results CD56 an-tigen was recorded in 19 out of 79 cases (24.1%) and particularly in those with M5 cytotypes. Moreover, CD56 expression was significantly associated with unfavorable cytogenetic abnormalities (P<0.05), Patients with t(8:21)had a significantly higher incidence (57.1%, 4/7) of CD56 expression than those with favora-ble karyotype(P<0.05). CD56~+ AML patients had a higher incidence of splenohepatomegalia and lactate dehydrogenase level than CD56~- patients(P<0.05). The median expression levels of MDR1 was statistical-ly higher in CD56~+ AML patients than that in CD56 patients(P<0.001). Patients with both high levels of MDR1 and CD56~+ had a significantly lower CR(complete remission) rate than those with both low MDR1 level and CD56 (58.8% vs 89.2%, P<0.01). Conclusion There is a linear correlation between MDR1 gene expression and CD56 expression in AML. Quantification of the MDR1 gene expression together with CD56 antigen expression is more effective to the judgement of prognosis in AML.

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