Evaluation of bioactive glass and platelet-rich plasma for bone healing in rabbit calvarial defects.

Bone regeneration is an important objective in clinical dental practice and has been used for different applications. The aim of this study was to evaluate the effectiveness of platelet-rich plasma (PRP) and bioactive glass (BG) for bone healing of surgical calvarial defects in rabbits. Two 8-mm defects were prepared in the parietal bones of ten animals, and the animals were randomly assigned to two groups. In each group, two subgroups were created with five defects each: BC - blood clot, BG, PRP and PRP + BG. Thus, four treatments were performed with five specimens each. The animals were sacrificed after 12 weeks and the specimens were analyzed radiographically, histologically and histomorphometrically. Data were subjected to ANOVA and Tukey's tests (α = 0.05). Outcomes demonstrated that the PRP group had higher bone density (%) values than the groups not treated with PRP (P < 0.05). Histometrically, both groups treated with PRP (PRP: 25.6 ± 9.9; PRP+BG: 25.8 ± 12.4) demonstrated higher percentages of new bone formation than the groups not treated with PRP (BG: 6.1 ± 4.3; BC: 7.8 ± 5.6) (P < 0.05). The results suggested that PRP improved bone repair and that bioactive glass alone, or in association with PRP, did not improve bone healing.

Efeito do stress no grau de inflamação gengival em adolescentes grávidas: estudo piloto / Effect of stress on the degree ofgingival inflammation in pregnant adolescents: pilot study

Objetivo: Avaliar a severidade de inflamação gengival perante duas condições, estresse e gravidez, em um grupo de adolescentes atendidas no serviço público de saúde na cidade de Maceió-AL. Material e métodos: 80 adolescentes grávidas com faixa etária ente 14 e 19 anos, atendidas em centros de referência ao atendimento pré-natal na cidade de Maceió-AL, participaram desse estudo piloto. O estresse social foi avaliado subjetivamente pelo teste de avaliação de estresse e a inflamação gengival foi avaliada pelo índice de inflamação gengival através de um exame clínico utilizando-se 6 dentes índices. A análise estatística foi executada relacionando o estresse social com dados demográficos e de hábitos de higiene oral e com relação a inflamação gengival pelo teste de Mann-Whitney e pelo teste de Fischer para variáveis dicotômicas. Resultados: Na avaliação da relação do estresse com a inflamação gengival e com o índice de placa com controle das variáveis independentes foi utilizada a regressão logística multivariada. Todos os testes foram aplicados com nível de confiança de 95%. O teste de Mann-Whitney demonstrou que as grávidas estressadas apresentavam maior frequência de escovação que as grávidas sem stress (p=0.008). Os outros dados demográficos e de hábitos de higiene oral se distribuíram igualmente entre os grupos. A análise por regressão logística multivariada demonstrou que nenhuma das variáveis independentes influenciou no índice gengival e no índice de placa em mulheres grávidas com ou sem stress. Conclusão: O estresse não causou aumento da severidade da inflamação gengival em adolescentes grávidas.

Objective: Evaluate the severity of gingival inflammation against two conditions, stress and pregnancy, in a group of adolescents treated at a public health service in Maceió-AL. Material and methods: 80 pregnant adolescents aged between 14 to 19 years being treated at referral centers for prenatal care in the city of Maceió-AL, participated in this pilot study. The social stress was subjectively evaluated by assessment of stress test (Lipp test) and gingival inflammation was assessed by the index of gingival inflammation (Loe & Silness) through a clinical examination using six index teeth. Statistical analysis was performed relating the social stress with demographic data and habits regarding oral hygiene and gingival inflammation using the Mann-Whitney and Fischer's test for dichotomous variables. Results: When considering the influence of the stress in gingival inflammation and plaque index with controlled of theindependent variables the multivariate logistic regression was used. All tests were applied with a confidence level of 95%. The Mann-Whitney test demonstrated that pregnant women under stress showed higher frequency of brushing than pregnant women without stress (p = 0.008). The other demographic and oral hygiene habits were equally distributed between the groups. A multivariate logistic regression analysis showed that none of the independent variables influenced the gingival index and plaque index in pregnant women with or without stress. Conclusion:The stress did not increase the severity of gingival inflammation in pregnant adolescents.