RESUMO
Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20--30 ng ml-1 1--2 h after administration; 72 h after administration, plasma concentrations are still measurable (5 ng ml-1). The analytical method involved a single extraction of I from the plasma into benzene followed by centrifugation, evaporation, and gas-chromatographic analysis of the samples.
Assuntos
Ansiolíticos , Benzodiazepinas , Diazepam/análogos & derivados , Nordazepam/análogos & derivados , Administração Oral , Adulto , Biotransformação , Humanos , Masculino , Nordazepam/administração & dosagem , Nordazepam/sangue , Fatores de TempoAssuntos
Demência/tratamento farmacológico , Arteriosclerose Intracraniana/tratamento farmacológico , Fosfolipídeos/uso terapêutico , Idoso , Proteínas Sanguíneas/análise , Córtex Cerebral , Circulação Cerebrovascular/efeitos dos fármacos , Demência/sangue , Avaliação de Medicamentos , Eletrocardiografia , Humanos , Injeções Intravenosas , Arteriosclerose Intracraniana/sangue , Lipídeos/sangue , Fosfolipídeos/administração & dosagemRESUMO
After carrying out a pilot study on D-7-chloro-1,3-dihydro-3-hemisuccinyloxy-5-phenyl-2H-1,4-benzodiaze-pine-2-one (D-oxazepam hemisuccinate sodium salt) (+), the authors examined in the present study the anxiolytic effects of this drug in comparison to its racemic form (+/-). The modifications of the symptoms were measured by the rating scale for anxiety (R.S.A.S.) of Hamilton and the experiment was carried out according to a cross-over, double-blind design. 34 patients hospitalized in the Psychiatric Hospital of Marzana (Verona) were studied. These patients complained of different syndromes but each of them had anxiety as the main symptom. The results obtained, evaluated clinically and statistically, confirm what was previously reported on the activity of D-oxazepam hemisuccinate sodium salt. In synthesis the drug given at a daily dose of 100 mg i.m. acts favourably upon: sleep disturbances, anxiety states and tension, somatic symptoms associated with anxiety. Given in equal doses both substances, dextrorotatory and racemic forms, act upon the same parameters of anxiety (as reported above). It has a superior activity over the racemic form, as it can be seen by the comparison of the variations of the general symptomatology and the single items particularly in the 2nd cycle of treatment.
