Successful management of Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon using vincristine and ticlopidine.

Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor that usually occurs in skin and retroperitoneum of infants and young children. We present a case of a newborn with a rapid tumor growth and a life-threatening Kasabach-Merritt syndrome with a progressive remission after treatment with vincristine and ticlopidine.

Acral lentiginous melanoma presents distinct clinical profile with high cancer susceptibility.

BACKGROUND: Acral lentiginous melanoma (ALM) is a distinct histological variant of cutaneous melanoma that presents a genomic profile different from the other variants. Our aim was to explore the distinctive clinical, pathological, and epidemiological characteristics of ALM. PATIENTS AND METHODS: A series of 978 patients with primary cutaneous melanoma was selected from a single referral center. Among these, 79 were located on acral sites and 46 presented an ALM. This group was compared with a group composed of 932 patients with the remaining three most frequent cutaneous melanoma variants. RESULTS: The ALM differed significantly from other variants: in an older age at diagnosis (65.52 vs. 51.79 years), a lower number of common (88.2 vs. 55.8%) and atypical nevi (95.0 vs. 80.2%), a predisposing genetic trait to cancer (22.2 vs. 7.1% had a personal history of other non-cutaneous malignancies and 58.1 vs. 36.4% had at least one first degree relative with non-cutaneous neoplasia) and lower number of sunburns (88.2 vs. 47.4% remembered none). Also, the tumors were thicker (mean of 2.94 vs. 2.03 mm), more frequently ulcerated (74.2 vs. 23.9%) and with perineural invasion (8.0 vs. 1.5%), had lower degree of inflammatory infiltrate (36.8 vs. 7.5% was absent) and were less frequently associated with a previous melanocytic lesion (8.3 vs. 32.6%). Differences were kept even after age-adjusted analyses. CONCLUSIONS: Our results, from a clinical and epidemiological point of view, support recent data on genetic characterization of melanomas. In comparison with the other frequent variants we have shown that ALM has some important differences which emphasize that it is a distinct entity more probably related to certain cancer susceptibility but unrelated to familial melanoma, tendency to developing nevus or sun exposure.

Radiation-induced temporary alopecia after embolization of cerebral aneurysms.

A 29-year-old woman underwent 2 endovascular procedures for treatment of bilateral carotid-ophthalmic artery aneurysms. After each treatment, transient alopecia occurred over the occipital area and is presumed to be radiation induced.

Angioma sudoríparo / Sudoriparous angioma

El angioma sudoríparo consiste en una rara proliferación vascular benigna que comparte una estrecha correlación clinicopatológica con el hamartoma angiomatoso ecrino y con algunas malformaciones vasculares. Histológicamente se caracteriza por la proliferación de vasos de gran calibre y dilatación de las estructuras ecrinas. Presentamos un nuevo caso de esta entidad localizado en la palma de la mano de un varón de 13 años

Sudoriparous angioma is a rare benign vascular proliferation which shares several clinico-pathologic features with both eccrine angiomatous hamartoma and some vascular malformations. Histologically, a proliferation of large vessels with adjacent dilated non-proliferative sweat ducts is found. We report a new case of this entity, located on the hand, in a 13-year-old male

Eczema de contacto agudo a parafenilendiamina contenida en tatuajes transitorios con henna / Acute contact eczema from paraphenylendiamine contained in temporary henna tattoos

La henna es una planta con propiedades colorantes que se usa, en ocasiones, mezclada con otras sustancias, como tinte para el pelo y el cuerpo. La parafenilendiamina (PPD) es uno de los aditivos que se emplea para acelerar el secado, mejorar la definición, y oscurecer su color rojizo. Existen varias descripciones en la literatura médica de sensibilización a PPD contenida en henna. Describimos 3 nuevos casos de dermatitis de contacto alérgica a tatuajes transitorios, con pruebas epicutáneas positivas para PPD en dos de ellos. En uno de los pacientes las lesiones se resolvieron dejando una hipopigmentación persistente. Es importante que la población conozca esta circunstancia y el riesgo que conlleva sensibilizarse a la PPD

Henna is a plant with coloring properties which is used as a dye for hair and skin, on occasion mixed with other substances. Paraphenylendiamine (PPD) is one of the additives used to accelerate drying, improve definition and darken its reddish color. There are several descriptions in literature of sensitization to the PPD contained in henna. We describe 3 new cases of allergic contact dermatitis to temporary tattoos, with skin tests positive for PPD in 2 of them. The lesions resolved in one of the patients, leaving persistent hypopigmentation. It is important for the population to be aware of this circumstance and the risk entailed by sensitization to PPD

[Acute contact eczema from paraphenylenediamine contained in temporary henna tattoos]. / Eczema de contacto agudo a parafenilendiamina contenida en tatuajes transitorios con henna.

Henna is a plant with coloring properties which is used as a dye for hair and skin, on occasion mixed with other substances. Paraphenylenediamine (PPD) is one of the additives used to accelerate drying, improve definition and darken its reddish color. There are several descriptions in literature of sensitization to the PPD contained in henna. We describe 3 new cases of allergic contact dermatitis to temporary tattoos, with skin tests positive for PPD in 2 of them. The lesions resolved in one of the patients, leaving persistent hypopigmentation. It is important for the population to be aware of this circumstance and the risk entailed by sensitization to PPD.