Joint report of SBI (Brazilian Society of Infectious Diseases), FEBRASGO (Brazilian Federation of Gynecology and Obstetrics Associations), SBU (Brazilian Society of Urology) and SBPC/ML (Brazilian Society of Clinical Pathology/Laboratory Medicine): recommendations for the clinical management of lower urinary tract infections in pregnant and non-pregnant women.

Urinary tract infection (UTI) is a common condition in women. There is an increased concern on reduction of bacterial susceptibility resulting from wrongly prescribing antimicrobials. This paper summarizes the recommendations of four Brazilian medical societies (SBI - Brazilian Society of Infectious Diseases, FEBRASGO - Brazilian Federation of Gynecology and Obstetrics Associations, SBU - Brazilian Society of Urology, and SBPC/ML - Brazilian Society of Clinical Pathology/Laboratory Medicine) on the management of urinary tract infection in women. Asymptomatic bacteriuria should be screened at least twice during pregnancy (early and in the 3rd trimester). All cases of significant bacteriuria (≥105CFU/mL in middle stream sample) should be treated with antimicrobials considering safety and susceptibility profile. In women with typical symptoms of cystitis, dipsticks are not necessary for diagnosis. Urine cultures should be collected in pregnant women, recurrent UTI, atypical cases, and if there is suspicion of pyelonephritis. First line antimicrobials for cystitis are fosfomycin trometamol in a single dose and nitrofurantoin, 100mg every 6hours for five days. Second line drugs are cefuroxime or amoxicillin-clavulanate for seven days. During pregnancy, amoxicillin and other cephalosporins may be used, but with a higher chance of therapeutic failure. In recurrent UTI, all episodes should be confirmed by urine culture. Treatment should be initiated only after urine sampling and with the same regimens indicated for isolated episodes. Prophylaxis options of recurrent UTI are behavioral measures, non-antimicrobial and antimicrobial prophylaxis. Vaginal estrogens may be recommended for postmenopausal women. Other non-antimicrobial prophylaxis, including cranberry and immunoprophylaxis, have weak evidence supporting their use. Antimicrobial prophylaxis may be offered as a continuous or postcoital scheme. In pregnant women, options are cephalexin, 250-500mg and nitrofurantoin, 100mg (contraindicated after 37 weeks of pregnancy). Nonpregnant women may use fosfomycin trometamol, 3g every 10 days, or nitrofurantoin, 100mg (continuous or postcoital).

Review on renal recovery after anatrophic nephrolithotomy: Are we really healing our patients?

The main goals for urinary stone treatment are to preserve renal function, reduce or avoid complications related to calculi, and to render the patient free of calculi as soon as possible. Anatrophic nephrolithotomy (ANL) is a valid and useful alternative for conventional staghorn calculi excision. Although excellent stone free rates can be achieved with ANL there are some drawbacks that may be of concern. Morbidity related to intraoperative and postoperative complications is one of them. Another, great concern is the possibility of reduction on renal function related to the procedure itself. This may be related to nephron injury during nephrotomy and parenchymal closure or to ischemic injury. In this review we assess functional results after anatrophic nephrolithotomy.

Following the needles: an anatomical study to evaluate the postoperative safety and symptoms of patients receiving a transobturator male sling implant.

PURPOSE: Implanting a transobturator male sling is a valid option to manage urinary incontinence after prostatectomy. We evaluated the trajectory of Argus T™ needles blindly introduced into the retropubic space to determine the safety and etiology of postoperative symptoms that can arise from this implant. MATERIALS AND METHODS: Needles were implanted and perineal dissection was performed in 20 fixed, adult human male cadavers. The distance was measured from the upper and lower extremities of the needles in the internal pelvic wall up to the obturator neurovascular bundle. Anatomical variations identified in this area proximal to the needles were characterized. The inguinocrural region was also dissected from the needles positioned there. Statistical analysis of the results was done. RESULTS: All needles transfixed the obturator internus muscle. Of the needles 90% were completely immersed in its fibers and not visible in the inner wall of the pelvis. The distance to the obturator neurovascular bundle and anatomical variations were noted. In the inguinocrural region the pectineus and adductor longus muscles were perforated in all cadavers. CONCLUSIONS: The needle sling implant preserves the obturator neurovascular bundle and obviates the potential for postoperative pelvic hematoma. The anatomical trajectory of the needles used for this implant account for the groin and perineal pain side effects. Based on similarities between the Argus T and other types of outside-in transobturator male slings the results of the current study could be extrapolated to the latter slings.

The Relationship Between Prostate Cancer Aggressiveness and Glycemic Levels in Patients Submitted to Radical Prostatectomy.

BACKGROUND: The relationship between hyperglycemia and prostate cancer remains controversial. According to current hypotheses, elevated serum glucose levels may lead to disease development or disease prevention. Our study examined the potential correlation between pre-operative glycemic levels of patients with prostate cancer and the grade of tumor aggressiveness. METHOD: We studied the case files of patients with a diagnosis of prostate cancer who had received putatively curative cancer surgery at the Urology Department of the Servidores do Estado Federal Hospital (RJ/Brazil). We transcribed information related to glycemia - collected up to 3 months before the surgery - and the histopathological grade of tumor aggressiveness (Gleason score) of the surgically removed prostates. RESULTS: We analyzed 42 people who met the inclusion criteria. Based on Gleason scores, among the normoglycemic patients, we detected low, moderate, and highly aggressive neoplasias in 13%, 53%, and 36% of the cases, respectively. For the hyperglycemic group, these rates were 30%, 60%, and 10%, respectively. Normoglycemic patients had primary Gleason grade 3 in 40% of the cases and grade 4 in 60% of the cases. For the hyperglycemic patients, these rates were 90% and 10%, respectively (P < 0.05 vs. grade 3 group). CONCLUSION: Both Gleason score and primary Gleason grade were lower in hyperglycemic patients with prostate cancer than in normoglycemic patients, suggesting a "protective action" of hyperglycemic states.

GreenLight HPS™ 120-W laser vaporization vs transurethral resection of the prostate (<60 mL): a 2-year randomized double-blind prospective urodynamic investigation.

UNLABELLED: What's known on the subject? and What does the study add? Photovaporization of the prostate (PVP) is now challenging TURP as the standard treatment for lower LUTS caused by BPH. The learning curve for PVP is short and the main advantages of this method over TURP are a shorter period of hospitalization, a shorter period of postoperative vesical catheterization, lower levels of retrograde ejaculation, rare development of dilutional hyponatraemia syndrome, the lack of a need for postoperative vesical irrigation as a result of extremely low indices of postoperative haematuria, and the lack of a need to suspend anticoagulant medication for the surgery. Traditionally, comparisons of the effectiveness of TURP vs PVP have involved parameters such as peak flow urinary rate and post-void residual urine volume measurements, and have employed questionnaires such as the IPSS and the International Index of Erectile Function instruments. However, studies evaluating detailed urodynamic parameters remain scarce and non-comparative The present study compared postoperative, medium-term urodynamic parameters among patients receiving TURP and high-power PVP. We consider the present study to be distinctive because it involved a double-blind, detailed functional analysis of the vesical emptying stage over the course of 2 years, and did not simply comprise an evaluation of clinical parameters and uroflowmetrics. We saw a reduction of infravesical obstruction, as shown by the significant reduction of ≥20 cm H(2)O in the mean micturition pressure for the groups studied, as well as a significant reduction in bladder outlet obstruction index. Thus, the present data show that high-power PVP can achieve and maintain the same results as TURP over a period of 24 months regarding an aspect that is particularly important for maintaining vesical health (i.e. detrusor pressure during the evacuation of the bladder). Such urodynamic data describing the functional outcome of PVP are currently missing from the literature. OBJECTIVE: To assess the impact of GreenLight HPS™ 120-W (American Medical System Incorporation, Minnetonka, MN, USA) laser photovaporization of the prostate (PVP) compared to transurethral resection of the prostate (TURP) on urodynamic results, voiding function and sexual function. PATIENTS AND METHODS: In total, 20 men with intermediate/severe lower urinary tract symptoms as a result of benign prostatic hyperplasia (BPH) were randomly selected and equally divided into two groups: TURP and PVP. Urodynamic evaluation was performed and International Prostate Symptom Score (IPSS), International Index of Erectile Function-5 and International Consultation on Incontinence Questionnaire - Short Form questionnaires were completed. The results were assessed at 2 years. RESULTS: Mean IPSS scores were reduced in both groups, although they did not differ between the TURP and PVP groups. There was no significant change in International Index of Erectile Function-5 scores. Half of the patients in the PVP group developed urge urinary incontinence with spontaneous resolution. The urodynamic parameters analyzed showed an improvement for both groups, although the values in the TURP group values were not significantly different from those in the PVP group. CONCLUSIONS: Bladder storage symptoms may represent a major concern, although they are of limited duration in patients undergoing PVP. High-power PVP can achieve and maintain the same results as TURP over a period of 24 months.

Análisis retrospectivo de la continencia urinaria en pacientes sometidos a braquiterapia post-resección transuretral prostática / Retrospective evaluation of urinary continence in patients submitted to brachytherapy after transurethral resection of the prostate gland

Introducción y objetivos: Algunos de los pacientes candidatos a la braquiterapia presentan historia previa de resección transuretral de la próstata (RTUP). La RTUP, sin embargo, crea una cavidad que puede llevar a algunas dificultades técnicas para la realización de braquiterapia. Tales condiciones tornan a la RTUP, previa a la braquiterapia, una contraindicación relativa a la realización de ésta. El objetivo del presente trabajo es evaluar las tasas de incontinencia urinaria en pacientes submetidos a braquiterapia después de una RTUP por medio de análisis retrospectiva. Materiales y métodos: En nuestro estudio analizamos 16 pacientes sometidos a RUTP previa a braquiterapia. Tras braquiterapia los pacientes fueron evaluados sobre síntomas del tracto urinario inferior a través del cuestionario ICS male SF. El intervalo de tiempo entre la RTUP y el tratamiento braquiterápico varió de 30 a 90 días, (media= 60 días). El seguimiento post braquiterapia varió entre 3 a 60 meses, (media= 30 meses). Resultados: Ninguno de los 16 pacientes evaluados presentó síntomas del tracto urinario inferior o incontinencia urinaria. Con el cuestionario ICS male SF la puntuación de interferencia en la calidad de vida obtuvo una media de 0,18 antes de la braquiterapia (variando de 0 a 1) y después de la braquiterapia de 0,20 (variando de 0 a 1) (p<0,001), donde las diferencias de los resultados no fue estadísticamente significativa. Algunas complicaciones fueron observadas como: disfunción eréctil, equimosis escrotal y retención urinaria. Los casos de disuria, equimosis escrotal y retención urinaria fueron de corta duración y resolución espontánea, éste último tras cateterismo vesical por 7 días. El paciente portador de disfunción eréctil presentó buena respuesta al uso semanal (3x/semana) de inhibidor de fosfodiesterasa tipo 5, después de un periodo de 6 meses. Conclusión: En concordancia con otros estudios, nosotros creemos que con alguna estrategia la RTUP no debería ser considerada una contraindicación relativa para la braquiterapia (AU)

Introduction and Objective: Some candidates for brachytherapy present with a previous history of prostate transurethral resection (TURP). Nonetheless, TURP generates a cavity that may lead to technical difficulties in performing brachytherapy. Such condition make a history of previous TURP a relative contra-indication for brachytherapy. The aim of this study is to evaluate the role of brachytherapy in urinary continence, in a group of patients with previous history of TURP. Materials and Methods: In our study, we analysed a group of 16 patients submitted to TURP pre-brachytherapy. The mean quality of life score from ICSmaleSF questionnaire ranged from 0 to 1 before and after brachytheraphy (average: 0,18 –before; average: 0,20 – after). There was no estatistically significant difference between the former values (p<0,001). After brachytherapy patients were evaluated for lower urinary tract symptoms. The time interval between TURP and brachytherapy ranged from 30 to 90 days (average: 60 days). Post-brachytherapy follow-up varied between 3 and 60 months (average: 30 months). Results: None of the 16 patients evaluated presented lower urinary tract symptoms nor urinary incontinence. Medical complications observed in patients were: dysuria, erectile dysfunction, scrotal ecchymosis and urinary retention . The cases of dysuria, scrotal ecchymosis and urinary retention observed were of short-duration, the last one with spontaneous resolution after 7 days of vesical catheterism. The patient presenting erectile dysfunction had a good response to oral type 5 fosfodiesteraseinhibitor three times a week, after a six month period. Conclusion: In accordance with other studies, we believe that with some strategy TURP should not be considered a relative contra-indication for brachytherapy (AU)