RESUMO
Serum level of soluble forms of adhesion molecules ICAM-1 and VCAM-1 has been evaluated in a group of patients presenting different clinical forms of uveitis. An increase in serum level of ICAM-1 has been found but not of VCAM-1. Serum level of VCAM-1 can be an useful marker of ocular inflammation in the evaluation of uveitis.
Assuntos
Molécula 1 de Adesão Intercelular/sangue , Uveíte/sangue , Molécula 1 de Adesão de Célula Vascular/sangue , Adolescente , Adulto , Idoso , Biomarcadores , Criança , Pré-Escolar , Feminino , Antígeno HLA-B27/análise , Humanos , Masculino , Pessoa de Meia-Idade , Solubilidade , Uveíte/classificaçãoRESUMO
We used computerized electroretinography (E.R.G.) flash to study 12 patients: five pseudohistoplasmosis (P.S.H.) and seven chronic idiopathic retinal vasculitis (C.I.R.V.), compared with 12 healthy controls. We found a moderate correlation in controls between white computer averaged b-wave amplitude and b-wave obtained with other wavelengths (over 600 nm red, over 550 nm orange, and under 500 nm blue), in scotopic (white/orange r = 0.41, P < 0.05; white/red r = 0.45, P < 0.05; white/blue r = 0.48, P < 0.02) and photopic conditions (white/orange r = 0.6, P < 0.01). For P.S.H. there was a highly significant correlation between white and all wavelengths in photopic (white/orange r = 1, white/red r = 0.96, P < 0.0001) and scotopic conditions (white/orange r = 0.97, P < 0.0001; white/red r = 0.96, P < 0.0001; white/blue r = 0.96). In vasculitis, as in controls, we found no white/red correlation and only in vasculitis we could not find a scotopic white/blue correlation. We conclude that these situations are electrophysiologically different. The closer correlation in P.S.H. suggests more efficient phototransduction and in C.I.R.V. there may also be a rod-selective dysfunction.
Assuntos
Eletrorretinografia , Infecções Oculares Fúngicas/fisiopatologia , Histoplasmose/fisiopatologia , Vasos Retinianos/fisiopatologia , Vasculite/fisiopatologia , Adulto , Doença Crônica , Feminino , Angiofluoresceinografia , Fundo de Olho , Humanos , Luz , Masculino , Pessoa de Meia-Idade , Estimulação Luminosa , Células Fotorreceptoras/fisiopatologia , Doenças Retinianas/fisiopatologia , Transdução de SinaisRESUMO
We have done two argon-laser iridotomies 24 and 72 hours before cataract surgery, to study ocular inflammation. We have taken aqueous samples to study IgA, IgG, C3 and AAT by laser immunonephelometry. All the proteins raised in the first 24 hours (P less than or equal to 0.01) except IgA in aqueous humor, taken with control levels, but only AAT (P less than or equal to 0.05), albumine at 72 hours (P less than or equal to 0.01) in aqueous humor. We tried to understand the observed gap by immunomodulation of released mediators.