RESUMO
In anesthetized dogs with cannulae implanted in the lateral cerebral ventricle, the water transfer from the CSF to the blood was studied using determination of drainage of tritiated water injected into the ventricle. Vasopressin and aldosterone accelerated the transfer of tritiated water into veins whereas angiotensin decelerated it. The data obtained suggest that the above hormones regulate volume and osmolality of the CSF.
Assuntos
Aldosterona/farmacologia , Angiotensina Amida/farmacologia , Angiotensina II/análogos & derivados , Arginina Vasopressina/farmacologia , Plexo Corióideo/metabolismo , Água/metabolismo , Animais , Líquido Cefalorraquidiano/fisiologia , Plexo Corióideo/efeitos dos fármacos , Cães , TrítioRESUMO
Histochemical study of the choroid plexus of the control and hydrated dogs injected with pituitrin solution (25 IU/kg bw) into the cerebral ventricle via a special cannula has demonstrated the ventricular surface of the choroid epithelium to bear compounds belonging to the class of glycosaminoglycans (GAG), primarily containing hyaluronic acid. The animals exposed to hydration showed an overt increase, whereas those treated with pituitrin a reduction in the content of GAG as compared with controls. The data obtained suggest that GAG contained by the choroid plexus are involved in the mechanism by which the rate of CSF formation is regulated.
Assuntos
Plexo Corióideo/metabolismo , Desidratação/metabolismo , Ingestão de Líquidos , Glicosaminoglicanos/metabolismo , Animais , CãesRESUMO
In chronic experiments on dogs with cannulae implanted in the lateral cerebral ventricle and occipital cistern, the CSF volume and Na+, K+ concentrations were measured during osmoregulating reaction and pituitrin infusion in the lateral ventricle. Isoosmotic CSF volume decrease in both experimental groups indicates that water-salt regulation in the body and brain tissues is performed by means of common neuro-humoral mechanisms with vasopressin participation.