RESUMO
Various means for changing the aggregative stability of emulsions in the system of benzylpenicillin fermentation broth filtrate and butyl acetate were tested. It was shown that the use of desemulgators was more efficient than the use of some means for removing the desemulgating admixtures. Moreover, addition of surface active substances after the preliminary thermocoagulation resulted in maximum decreasing of the emulsion aggregative stability.
Assuntos
Penicilina G/isolamento & purificação , Acetatos/farmacologia , Meios de Cultura , Estabilidade de Medicamentos , Emulsões , Concentração de Íons de Hidrogênio , Técnicas In Vitro , Penicilina G/administração & dosagem , Soluções , Solventes/farmacologia , Temperatura , Ultrafiltração/métodosRESUMO
Inactivation of benzylpenicillin in real media i.e. fermentation broths and their filtrates was studied in comparison with the published data on inactivation of commercial benzylpenicillin in aqueous solutions as dependent on the medium pH and temperature. The lowest constant of benzylpenicillin inactivation was shown to be in the fermentation broths.