Dientes retenidos de presentación clínica poco frecuente: kissing molars / Impacted teeth of uncommon clinical presentation: kissing molars

En el siguiente trabajo se presentan dos casos clínicos de retención dentaria compleja y sus respectivos protocolos quirúrgicos. Realizando una revisión de la literatura mundial estos casos son descriptos como "Kissing Molars". El primero de los casos corresponde a una mujer de 17 años que presentaba retención de las piezas dentarias 47 y 48 con sus caras oclusales contactando en íntima relación. El segundo caso clínico corresponde a una mujer de 24 años que presentaba retención dentaria "Kissing Molars", pero en este caso incluye tercer y cuarto molar inferior derecho. En ambos casos, tras un estudio exhaustivo y diagnóstico preciso, se realizaron los procedimientos quirúrgicos correspondientes (AU)

In this workshop, two clinic cases of complex teeth retention are presented and its surgery records. Doing a review in worldwide literature, these facts are described as "Kissing Molars". The first one belongs to a 17 year-old woman who showed 47 and 48 dental pieces retention with oclusal faces touching. The second clinic case belongs to a 24 year-old woman who presented "Kissing Molars", but in this one third and fourth right lower molar is included. In both cases, after an comprehensive study and accurate diagnosis, surgical protocols were done (AU)

Lewis x Antigen is Associated to Head and Neck Squamous Cell Carcinoma Survival.

Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with poor prognosis without appropriate prognostic markers. Previous research shows that Lewis antigens have been involved in carcinoma dissemination and patients´ survival. Fucosyl and sialyltransferases are the enzymes implicated in the Lewis antigens synthesis. The purpose of this study was to evaluate the prognostic utility of Lewis antigens in HNSCC. We conducted a prospective research including histological samples from 79 patients with primary HNSCC. Lewis x and sialyl Lewis x expression were detected by immunohistochemistry; patient's data, progression free, and overall survival were documented. A statistical correlation study of antigenic expression and patients´ histopathological variables was performed. Cox regression models with internal validation procedures were employed to analyze survival data. By immunohistochemistry, Lewis x was detected in 34/79 (43%) tumor samples, while sialyl Lewis x only in 11/79 (14%). Lewis x expression showed a positive correlation with tumor differentiation and a better overall survival for Lewis x + patients was detected. Moreover, multivariate Cox's regression analysis showed that Lewis x is an independent predictor of better overall survival. The in silico analysis supported the presence of deregulated fucosyl (FUT4) and sialyltransferase (ST3GAL4) in the Lewis synthetic pathway related to patient survival. These results suggest that Lewis x expression is associated with a better outcome in patients with HNSCC.