RESUMO
We are presenting the immunologic pattern of 100 patients with kidney transplant made from 1990-2000 at CHM CSS Dr.AAM. Eighty nine were alive related donors. Most of them were from blood group O, donors and receptors. They came from Panama, Chiriqui and Colon. Many of the donors were siblings. The grades of compatibility in frequency were D, C, A & B. For locus HLA-A the most common gen was A2 for transplanted patients and for the rest of the Panamanian population is A24. For the locus HLA-B were B35 and B38 respectively and for the locus HLA-C the most common gen was C4, and C3 for the rest of the population.
Assuntos
Antígenos HLA/análise , Transplante de Rim/imunologia , Feminino , Humanos , MasculinoAssuntos
Transplante de Rim/estatística & dados numéricos , Sistema de Registros , Obtenção de Tecidos e Órgãos/estatística & dados numéricos , Cadáver , Causas de Morte , Humanos , Hipertensão , Transplante de Rim/mortalidade , América Latina , Nefrologia , Estudos Retrospectivos , Sociedades Médicas , Doadores de Tecidos , Obtenção de Tecidos e Órgãos/organização & administração , Listas de EsperaRESUMO
Erythropoietin (EP) injected subcutaneously (SC) 2 or 3 times a week, respectively, or intravenously (IV) 3 times a week, increased the hemoglobin and the hematocrit of all the patients so treated. The total units of EP used was less when it was administered SC. EP once or twice a week, respectively, administered SC also increased the hemoglobin and hematocrit in each case, and the total amount of EP used was also less
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Anemia/terapia , Diálise Renal/efeitos adversos , Eritropoetina/administração & dosagem , Insuficiência Renal Crônica/sangue , Anemia/sangue , Anemia/etiologia , Esquema de Medicação , Hematócrito , Hemoglobina A , Insuficiência Renal Crônica/terapia , Injeções IntravenosasRESUMO
Erythropoietin (EP) injected subcutaneously (SC) 2 or 3 times a week, respectively, or intravenously (IV) 3 times a week, increased the hemoglobin and the hematocrit of all the patients so treated. The total units of EP used was less when it was administered SC. EP once or twice a week, respectively, administered SC also increased the hemoglobin and hematocrit in each case, and the total amount of EP used was also less.
Assuntos
Anemia/terapia , Eritropoetina/administração & dosagem , Falência Renal Crônica/sangue , Diálise Renal/efeitos adversos , Adulto , Anemia/sangue , Anemia/etiologia , Esquema de Medicação , Feminino , Hematócrito , Hemoglobina A , Humanos , Injeções Intravenosas , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-IdadeRESUMO
The authors determined the frequency of genes and haplotypes of the HLA system in 965 panamanian men and women not related to each other, between 6 and 65 years of age. The HLA-A locus genes with the highest frequency (f) were A2, with f 0.1763; A24, f 0.1584; A30, f 0.1340; A23, f 0.1069; A3, f 0.0774. The other 20 genes each had less than 0.07. The genes with the highest frequency for locus HLA-B were B35, f 0.1946; B44, f 0.0904; B7, f 0.0774; B60 and B61, f 0.0582. For locus HLA-C, the most frequent genes were Cw3 with f 0.1549 and Cw4, f 0.1444. For locus HLA-DR, the most frequent genes were DR2 with f 0.1283; DR3, f 0.0620; DR7, f 0.0409. The most frequent haplotypes in the panamanian population were A2-B35 with f 0.0382; A3-B35, f 0.0191; A24-35, f 0.0287; A24-B61, f 0.0239; A29-B44, f 0.0287; A30-B42, f 0.0239; A23-B44, f 0.0191; A1-B8, f 0.0143. The authors conclude that the panamanian population exhibits a high degree of polymorphism for loci HLA-A, B and C, while for locu HLA-DR the frequency is the median when compared with that in caucasian, negro and oriental groups; and that, according to locus, predominant genes originating from these groups and found, corroborating the multiracial origen of the panamanian population.
Assuntos
Frequência do Gene , Antígenos HLA/genética , Haplótipos , Adolescente , Adulto , Criança , Feminino , Antígenos HLA-A/genética , Antígenos HLA-B/genética , Teste de Histocompatibilidade , Humanos , Masculino , Pessoa de Meia-Idade , Panamá , Polimorfismo GenéticoRESUMO
The authors determined the frequency of genes and haplotypes of the HLA system in 965 panamanian men and women not related to each other, between 6 and 65 years of age. The HLA-A locus genes with the highest frequency (f) were A2, with f 0.1763; A24, f 0.1584; A30, f 0.1340; A23, f 0.1069; A3, f 0.0774. The other 20 genes each had less than 0.07. The genes with the highest frequency for locus HLA-B were B35, f 0.1946; B44, f 0.0904; B7, f 0.0774; B60 and B61, f 0.0582. For locus HLA-C, the most frequent genes were Cw3 with f 0.1549 and Cw4, f 0.1444. For locus HLA-DR, the most frequent genes were DR2 with f 0.1283; DR3, f 0.0620; DR7, f 0.0409. The most frequent haplotypes in the panamanian population were A2-B35 with f 0.0382; A3-B35, f 0.0191; A24-35, f 0.0287; A24-B61, f 0.0239; A29-B44, f 0.0287; A30-B42, f 0.0239; A23-B44, f 0.0191; A1-B8, f 0.0143. The authors conclude that the panamanian population exhibits a high degree of polymorphism for loci HLA-A, B and C, while for locu HLA-DR the frequency is the median when compared with that in caucasian, negro and oriental groups; and that, according to locus, predominant genes originating from these groups and found, corroborating the multiracial origen of the panamanian population
