Cancer antigens 19.9 and 125 as tumor markers in patients with mucinous ovarian tumors.

PURPOSE OF INVESTIGATION: To determine the accuracy of carcinoembryonic antigen (CEA), cancer antigen (CA) 15.3, CA 19.9, and CA 125 for diagnosis of mucinous ovarian cancer (MOC). MATERIALS AND METHODS: Samples were collected preoperatively from patients with mucinous ovarian tumor. The following variables were analysed: CEA, CA 15.3, CA 19.9, and CA 125. After surgery, histology and stage were determined according to FIGO-classification. Patients were classified into two groups according to the diagnosis of ovarian biopsy: NOT MOC and MOC. RESULTS: The authors studied 94 patients with ages between 15 and 80 years (median = 43). Eighty-two patients were NOT MOC (68 mucinous ovarian cystadenomas and 14 mucinous borderline ovarian tumors) and 12 were MOC. All MOC patients were in FIGO Stages I or II. No statistically significant differences were found between MOC and NOT MOC patients according to CEA and CA 15.3 (p > 0.05). All MOC patients had abnormal serum CA 19.9 and/or CA 125 levels. Using CA 19.9 and CA 125, we performed a linear regression formula CA 19.9+125 = 0.00102 x CA 19.9 + 0.00057 x CA 125. AUCs values were 0.862 (p = 0.0002), 0.829 (p = 0.0021), and 0.911 (p = 0.0001) for CA 19.9, CA 125, and CA 19.9 + 125, respectively. CA 19.9 + 125 exhibited 95.1% specificity and 66.7% sensitivity, increased by 16.7% sensitivity compared with using only CA 19.9 or CA 125. CONCLUSIONS: Preoperative CA 19.9 and CA 125 levels showed high diagnosis efficacy to predict whether a mucinous ovarian tumour is benign or malignant. Using both markers simultaneously increases the sensitivity for diagnosis of MOC.

Tuberculosis multirresistente en la Bahía de Cádiz / Multidrug-resistant tuberculosis in the Bay of Cadiz, Spain

Estudiamos 182 pacientes diagnosticados de tuberculosis con el fin de conocer la incidencia de multirresistencia en la Bahía de Cádiz. Las cepas responsables, 173 Mycobacterium tuberculosis y 9 M. hovis, se identificaron mediante hibridación con sondas y técnicas moleculares de RFLP (restriction fragment length Poli morphism) y spoligotyping (spacer oligonucle olido typing). Se detectó algún tipo de resistencia en 51 pacientes (28,0 por ciento), primaria en el 20,9 por ciento y secundaria en el 7, I por ciento. Encontramos cepas multirresistentes en un 12,6 por ciento de pacientes (23,1 por ciento VIII positivos v 8,5 por ciento VIH negativos). La tasa de multirresistencia en Cádiz es superior a las detectadas en otras zonas de España y se asocia preferentemente con infección por el virus de la inmunodeficiencia humana (AU)