RESUMO
BACKGROUND: Local preparation of rectum governs the possibly survenue of complications during transrectal ultrasound guided biopsies of prostate. OBJECTIVE: To determine the efficacy and acceptability of rectal preparation (Eductyl(®) suppository) in patients undergoing a transrectal prostate biopsy. PATIENTS AND METHODS: From May to August 2005, eight urologists (Bel-Air Urological Center, Bordeaux) included 137 patients (mean age 66.4 years) with an indication of prostate biopsies. All patients were administrated prophylactic antibiotic therapy. They used Eductyl(®) effervescent suppositories for local preparation, the day before and/or the morning of the exam. RESULTS: Rectal vacuity was satisfactory or very satisfactory for 99% of patients. Introduction of probe and tracking of prostate were easy or very easy in 99% of cases. Eight days after the exam, only 35% of patients had suffered anal or rectal pain during a mean of 2 days. Most of patients recovered bowel function without requiring treatment and without any difficulty or pain. The bowel function recovery occurred the day of prostate biopsy and the day after for 28.4% and 62.2% of patients, respectively. CONCLUSION: Urologists considered that the use of Eductyl(®) suppositories before prostate biopsies ensured a satisfactory rectal preparation and optimal conditions for the exam. Moreover, this preparation was well accepted by patients.
Assuntos
Antibioticoprofilaxia , Infecções Bacterianas/prevenção & controle , Biópsia por Agulha , Cuidados Pré-Operatórios , Próstata/patologia , Infecções Bacterianas/etiologia , Biópsia por Agulha/efeitos adversos , Dióxido de Carbono/uso terapêutico , Humanos , Masculino , Estudos Retrospectivos , SupositóriosRESUMO
The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of eukaryotic POL II promoters for which the transcription start site has been determined experimentally. Access to promoter sequences is provided by pointers to positions in nucleotide sequence entries. The annotation part of an entry includes a description of the initiation site mapping data, exhaustive cross-references to the EMBL nucleotide sequence database, SWISS-PROT, TRANSFAC and other databases, as well as bibliographic references. EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets for comparative sequence analysis. WWW-based interfaces have been developed that enable the user to view EPD entries in different formats, to select and extract promoter sequences according to a variety of criteria, and to navigate to related databases exploiting different cross-references. The EPD web site also features yearly updated base frequency matrices for major eukaryotic promoter elements. EPD can be accessed at http://www.epd.isb-sib.ch
Assuntos
Bases de Dados Factuais , Regiões Promotoras Genéticas , Sistemas de Gerenciamento de Base de Dados , Células Eucarióticas , Internet , Interface Usuário-ComputadorRESUMO
The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of eukaryotic POL II promoters, for which the transcription start site has been determined experimentally. Access to promoter sequences is provided by pointers to positions in nucleotide sequence entries. The annotation part of an entry includes description of the initiation site mapping data, cross-references to other databases, and bibliographic references. EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets for comparative sequence analysis. Recent efforts have focused on exhaustive cross-referencing to the EMBL nucleotide sequence database, and on the improvement of the WWW-based user interfaces and data retrieval mechanisms. EPD can be accessed at http://www.epd.isb-sib.ch
Assuntos
Bases de Dados Factuais , Células Eucarióticas , Regiões Promotoras Genéticas/genética , RNA Polimerase II/fisiologia , Algoritmos , Animais , Sequência de Bases , Genes Virais/genética , Genoma , Armazenamento e Recuperação da Informação , Internet , RNA Mensageiro/genética , Homologia de Sequência do Ácido Nucleico , Transcrição Gênica/genética , Interface Usuário-ComputadorAssuntos
Educação em Enfermagem/métodos , Docentes de Enfermagem , Escolas de Enfermagem , Currículo , Humanos , SuíçaRESUMO
The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collection of experimentally characterised eukaryotic POL II promoters. The underlying definition of a promoter is that of a transcription initiation site. All information presented in EPD results from an independent evaluation of primary experimental data shown in the biological literature. Sequences flanking transcription initiation sites are indirectly given by pointers to EMBL sequences. The annotation part of a promoter entry includes description of the promoter-defining evidence, cross-references to other databases, and bibliographic references. Being designed as a resource for comparative sequence analysis, EPD is structured in a way that facilitates dynamic extraction of biologically meaningful promoter subsets. The database is available through the World Wide Web at URL http://cmpteam4.unil.ch
