RESUMO
BACKGROUND: Drug-induced hypersensitivity syndrome is an uncommon but potentially life-threatening idiosyncratic drug reaction. It is usually due to aromatic anti-convulsants. We report the second case induced by sodium valproate, a non-aromatic anticonvulsant. CASE REPORT: A 28-year-old woman was treated with sodium valproate for 5 weeks. She suddenly developed a generalized maculo-papulous eruption with fever, node enlargement, hypereosinophilia and altered liver function. DISCUSSION: Drug-induced hypersensitivity is rarely induced by valproic acid. The time-course and positive patch tests using the diluted drug establish the diagnosis.
Assuntos
Anticonvulsivantes/efeitos adversos , Toxidermias/etiologia , Hipersensibilidade a Drogas/etiologia , Ácido Valproico/efeitos adversos , Adulto , Anticonvulsivantes/uso terapêutico , Toxidermias/diagnóstico , Hipersensibilidade a Drogas/diagnóstico , Feminino , Humanos , Testes do Emplastro , Ácido Valproico/uso terapêuticoRESUMO
INTRODUCTION: We report a new case of eccrine carcinoma with mucinous stroma characterized by its voluminous exophytic growth. CASE REPORT: An 80-year-old patient was hospitalized for a voluminous vegetating tumor localized over the left temporal region and which had developed over the 10 preceding years. Wide exeresis was performed and histology confirmed the diagnosis of eccrine carcinoma. No locoregional recurrence was noted 18 months later. DISCUSSION: Eccrine carcinoma with mucinous stroma, also termed eccrine mucinous adenocarcinoma, is a rare adnexal skin carcinoma usually localized on the face or scalp. Abundant zones of mucine are characteristic dissociating a dermal cell proliferation with ruban architecture. The volume of the tumor in our case was particularly remarkable although outcome was favorable after surgical treatment.
Assuntos
Adenocarcinoma Mucinoso/diagnóstico , Glândulas Écrinas , Neoplasias Faciais/diagnóstico , Adenocarcinoma Mucinoso/cirurgia , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Neoplasias Faciais/cirurgia , Feminino , Humanos , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/cirurgiaRESUMO
Localized elastolysis refers to a group of heterogeneous conditions which includes cutis laxa. We report a form of localized and non-inflammatory elastolysis evocative of cutis laxa, localized to the anteromedial aspect of the left thigh and knee, acquired at the age of 8 years and associated with unilateral adjacent venous dilatations appearing at the age of 39 years. Our case is clinically and ultrastructurally compatible with cutis laxa. Localized forms of cutis laxa not preceded by inflammation are exceptional; localization on the leg has never been described. This clinical form of elastolysis calls into question the classification of acquired elastolysis. The adjacent varicose veins also raise the question of the risk of subcutaneous damage in this condition.
