[Evaluation of occupational risk for workers producing polyvinyl chloride resin pipes, profiles and fixtures]. / Otsenka na profesionalniia risk na rabotnitsite v proizvodstvo na trubi, profili i fitingi ot polivinilkhloridna smola.

Studies are performed on work and hygienic conditions in the production of pipes, profiles and fittings from polyvinylchloride resin, in relation to the toxic factor. Concentrations above TLV are established for vinylchloride, vinylchloride resin dust, phthalates and lead aerosols. Complex clinico-laboratory examinations are carried out on 133 workers, as special attention is paid to the nervous system, liver function, cardio-vascular system and the skeleton system. In 15 workers are established data for toxic effect of vinylchloride, and in other 5 workers - toxic pneumosclerosis, which is a result both from vinylchloride and vinylchloride resin dust. Hygienic and medico-preventive measures are developed.

[The occupational risk in the manufacture of mineral pigments and iron oxide dyes]. / Profesionalen risk pri proizvodstvo na mineralni pigmenti i zhelezno-oksidni boi.

The mineral pigments and ferric oxide dyes are used on a large scale in the paint and varnish industry, in building, chemical industry, polygraphy etc. For their production as basic raw materials are used lead, chromium and iron compounds. The concentrations of the toxic and accummulating lead and chromium in the air of the work environment surpass MAC and create most frequently "especially unfavourable" conditions of work. In all industrial processes the leading unfavourable factor is the chemical combined with unfavourable physical factors and overstress on the locomotor system. Changes were established in the organism of examined workers as result from the chronic effect of the factors of the work environment of the peripheral blood, digestive, nervous system and the skin. In view of reducing the risk of exposure to the toxic chemical factor it is imposed to take measures for sanitation of the work environment.

[Neurovegetative reactivity among female workers systematically locally exposed to cold and overexertion]. / Nervno-vegetativna reaktivnost u rabotnitsi, podlozheni na sistemno lokalno studovo vuzdeistvie i prenaprezhenie.

Workers from different occupations associated with cooling of the upper extremities are exposed to chronic local cold effect in their daily work. The objects of the present study were 45 females, engaged in packing of cooled fruits and vegetables, stored in freezing chambers. The following methods were used aiming at the studies on the neurovegetative reactivity and the task proceeding from it in objectivization of the neurovegetative disturbances of the upper extremities: directed neurologic and autonomic anamnesis, routine neurological state, clinical-functional autonomic tests and methods. Anamnestically, complaints were established in 97.78 per cent from all the examined, the majority of them objectivizing the neurovegetative angiodystonic disturbances of the upper extremities with a difference, statistically significant, versus the control group (p less than 0.05.0%). Those alterations could be interpreted in connection with the factors of the working environment - chronic local cold effect and overstrain of the upper extremities.

[17-ketosteroids in the 24-hour urine of miners with vibration disease from local vibration exposure]. / Vurkhu 17-ketosteroidite v 24-chasova urina pri min'ori s vibratsionna bolest ot lokalno vibratsionno vuzdeistvie.

The 17-ketosteroid level in the urine secreted in 24 hours s studied in miners with vibration disease. The case material is analyzed according to age, working service, clinical syndromes and stage. It is demonstrated that the continuous effect of local vibrations lead to inhibition of the adrenal function, manifested by a 17-ketosteroids fall. Such a lowering is assumed as one of the adaptational syndrome-manifestations. Regulation of corticosteroid secretion is discussed in the light of complex interrelations--neuroendocrine, biochemical and homeostatic. The role played by oxidation processes is also emphasized. 17-ketosteroids content in the urine has certain diagnostical value, irrespective of the fact that its lowering is by no means a specific manifestation of the vibration disease.