RESUMO
Eighty-eight patients with endoscopically proven gastric and duodenal ulceration were treated with ranitidine ( Zantac ; Glaxo) or an antacid preparation containing aluminium hydroxide and magnesium trisilicate ( Gelusil ; Warner) over a 4-week period to assess healing. Clinical, haematological and biochemical assessment and endoscopy were performed at the beginning and at the end of this period. Of the duodenal ulcers, 74% healed on ranitidine therapy and 63% on Gelusil . This difference was not statistically significant (chi 2(1) = 0,55). Of the gastric ulcers 58% healed on ranitidine therapy and 35% on Gelusil , but this difference did not reach statistical significance (chi 2(1) = 1,79). There was no significant difference between the two therapies with regard to symptomatic relief in the duodenal ulcer group, but ranitidine produced significantly better results in the gastric ulcer group. No side-effects were noted in either group.
Assuntos
Antiácidos/uso terapêutico , Úlcera Duodenal/tratamento farmacológico , Ranitidina/uso terapêutico , Úlcera Gástrica/tratamento farmacológico , Ensaios Clínicos como Assunto , Úlcera Duodenal/fisiopatologia , Humanos , Fatores Sexuais , Fumar , Úlcera Gástrica/fisiopatologia , Fatores de TempoRESUMO
Twenty consecutive patients with ulcerative colitis were evaluated at the Gastro-intestinal Clinic, Tygerberg Hospital, with special reference to the biochemical tests and histological findings in the liver. Abnormal liver function tests warrant a liver biopsy, since the underlying liver disease influences the subsequent prognosis and treatment.
Assuntos
Colite Ulcerativa/complicações , Hepatite/complicações , Adulto , Doença Crônica , Feminino , Hepatite/patologia , Humanos , Fígado/patologia , Masculino , Pessoa de Meia-IdadeRESUMO
A case of severe vitamin B12 neuropathy (subacute combined degeneration of the spinal cord) in the absence of anaemia is described and a short review of the literature presented.
Assuntos
Doenças da Medula Espinal/etiologia , Deficiência de Vitamina B 12/complicações , Adulto , Feminino , HumanosRESUMO
Prolonged exposure to organophosphates in low concentrations caused diarrhoea in 38 students, lecturers and other personnel at an agricultural college. The symptoms of those affected, plasma pseudocholinesterase levels, topography of the orchards and vegetable gardens, the various insecticides and quantities used, and the exposure due to prevailing winds have been studied. We conclude that safety and precautionary measures must be strictly enforced.