RESUMO
Two middle-aged black women reported hyperpigmentation of the face after using bleaching creams containing hydroquinone. Both noted initial lightening of facial pigmentation followed by progressive darkening of the areas to which the cream was applied. After biopsy, they were found to have exogenous ochronosis. These are the fifth and sixth cases of exogenous ochronosis reported in the United States. In this article we review the literature and discuss the possible pathogenesis of exogenous ochronosis.
Assuntos
Ocronose/epidemiologia , Adulto , Feminino , Humanos , Hidroquinonas/efeitos adversos , Masculino , Pessoa de Meia-Idade , Ocronose/induzido quimicamente , Ocronose/patologia , Fenol , Fenóis/efeitos adversos , Resorcinóis/efeitos adversos , Pele/patologia , Estados UnidosRESUMO
Epithelioid sarcoma is familiar to orthopedic surgeons but not to dermatologists. Because this malignant neoplasm presents as a subcutaneous mass, often with overlying epidermal changes, the patient may be seen by a dermatologist for evaluation. The differential diagnosis often includes nodular fasciitis and tenosynovitis. The histopathologic interpretation of the biopsy specimen may be difficult, so it is helpful for the physician to suspect and consider epithelioid sarcoma in the differential diagnosis given to the pathologist. Early, accurate diagnosis can be achieved and can thus spare the patient significant morbidity or even death.
Assuntos
Sarcoma/patologia , Neoplasias Cutâneas/patologia , Adulto , Diagnóstico Diferencial , Antebraço , Humanos , Neoplasias Pulmonares/secundário , Masculino , Recidiva Local de Neoplasia/patologiaRESUMO
Reports of local and systemic complications from topically applied corticosteroids used in the treatment of inflammatory dermatoses warrant a re-examination of other methods of therapy. The specific measures suggested in this paper for treating seborrheic dermatitis, psoriasis, and atopic dermatitis may also be applied to eczematous eruptions that are in similar stages of development.
