1.
Int J Pharm
; 201(2): 221-37, 2000 May 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10878328
RESUMO
Three solid state forms of stavudine designated forms I, II and III have been identified and characterized. Forms I and II are anhydrous polymorphs whereas form III is hydrated and is pseudopolymorphic with forms I and II. Physico-chemical and thermodynamic properties of the three solid state forms have been characterized. Solid-state stability and potential for interconversion of the forms to aid in the selection of preferred form for development and commercialization has been studied. Conditions of recrystallization governing the formation of thermodynamically most stable polymorphic form I devoid of other forms was identified.
Assuntos
Fármacos Anti-HIV/química , Estavudina/química , Fármacos Anti-HIV/administração & dosagem , Varredura Diferencial de Calorimetria , Fenômenos Químicos , Físico-Química , Cristalização , Espectroscopia de Ressonância Magnética , Solventes , Espectroscopia de Infravermelho com Transformada de Fourier , Análise Espectral Raman , Estavudina/administração & dosagem , Termodinâmica , Termogravimetria , Difração de Raios X
2.
Am J Hosp Pharm
; 46(2): 258-9, 1989 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2653024