RESUMO
OBJECTIVE: To assess the long-term association between childhood television viewing and adult unemployment, and if this association is mediated by educational achievement. METHOD: Study members were a general-population birth cohort of 1037 participants born in New Zealand in 1972/1973. Hours of weekday television viewing were reported at ages 5-15. Since age 18, unemployment was assessed retrospectively using life-history calendars to age 32. Information on educational qualifications was collected at age 32. RESULTS: Childhood and adolescent television viewing predicted adult unemployment. This association was significant for male Study members only (ß=0.20, p<0.0001). The association for male Study members remained after further controlling for socioeconomic status, cognitive ability, and early indications of behaviour problems (p<0.0007). The association was only partially mediated by educational achievement and television viewing remained a predictor of unemployment after adjusting for this (p=0.0035). By logistic regression, each additional hour of daily television viewing was associated with an increased likelihood of spending at least 6 months in unemployment between ages 18 and 32 years (OR=1.36, 95%, CI=1.06, 1.76, p=0.0157). CONCLUSION: Childhood and adolescent television viewing may have long-lasting consequences for adult unemployment for boys. This association is only partially explained by the association between television viewing and educational achievement.
Assuntos
Comportamento do Adolescente , Proteção da Criança/estatística & dados numéricos , Comportamento Sedentário , Televisão/estatística & dados numéricos , Desemprego/estatística & dados numéricos , Adolescente , Adulto , Criança , Pré-Escolar , Intervalos de Confiança , Escolaridade , Feminino , Humanos , Modelos Logísticos , Masculino , Nova Zelândia , Razão de Chances , Psicometria , Estudos Retrospectivos , Medição de Risco/métodos , Estatística como Assunto , Estatísticas não Paramétricas , Adulto JovemRESUMO
Serine palmitoyltransferase is the first and rate-limiting enzyme of sphingolipid synthesis. As such, it is a central control point in the synthesis of bioactivate sphingolipids, and it plays an important role in mediating cellular stress responses. In this review, its role in mediating these responses is discussed within the context of de novo ceramide synthesis. Furthermore, a discussion is provided of its regulation as discerned from both yeast and mammalian studies.
