1.
Org Biomol Chem
; 22(4): 735-740, 2024 01 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38168802
RESUMO
Molnupiravir, the prodrug for ß-D-N4-hydroxycytidine (NHC), is marketed by Merck as Lagevrio™ against mild-moderate COVID-19, under FDA emergency use authorization. It is the first oral drug against the disease. This work describes two synthetic approaches to NHC and molnupiravir by amide activation in uridine with a peptide-coupling agent and with a 4-chloropyrimidinone nucleoside intermediate.