Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Dermatol Ther ; 34(3): e14911, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33619833

RESUMO

Alitretinoin is the only systemic agent approved to treat moderate-severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids. No nationwide Italian data regarding real-life efficacy, safety, and tolerability of treatment are available. The DECISA project (DErmatology Clinics in Italy: Survey on Alitretinoin) retrospectively examined data from a registry including 15 Dermatology Clinics authorized to prescription of alitretinoin for CHE patients. Disease severity was assessed at baseline, and after 3 and 6 months of treatment, using the 5-point Physician Global Assessment (PGA) and the modified Total Lesion-Symptoms-Severity (mTLSS) scores. Between November 2010 and July 2018, data of 248 male and 190 female patients (mean age 49.71 ± 13.20 years) treated with alitretinoin were collected. Of them, 43.2% had irritant contact dermatitis, 22.2% allergic contact dermatitis, 18.0% atopic dermatitis, 16.7% mixed (irritant/allergic) type of eczema. At 3 months, the 420 re-evaluated patients showed significantly reduced mTLSS and PGA (P < .0000001 vs baseline for both); PGA was clear/almost clear in 35.6% of cases. At 6 months, the 341 re-evaluated patients showed significant (P < .0000001) improvement of mTLSS and PGA vs baseline and 3 months (PGA clear/almost clear: 41.4%). Relapses occurred in 125 patients; 58 underwent an additional course of alitretinoin, with similarly good results. No relevant safety issues were reported; 86 patients experienced adverse effects, which forced 40 to prematurely stop treatment. The DECISA project results confirm the real-life efficacy, safety and tolerability of alitretinoin in the treatment of moderate to severe CHE refractory to standard topical therapies.


Assuntos
Fármacos Dermatológicos , Dermatologia , Eczema , Dermatoses da Mão , Adulto , Alitretinoína , Doença Crônica , Fármacos Dermatológicos/efeitos adversos , Eczema/diagnóstico , Eczema/tratamento farmacológico , Feminino , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/tratamento farmacológico , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Tretinoína/efeitos adversos
2.
Dermatitis ; 15(2): 75-7, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15473333

RESUMO

We report a case in which burning mouth syndrome (BMS) was associated with a strong allergy to mercury. The aim of this case history is to strengthen knowledge of the relationship among allergy to mercury, systemic allergic contact dermatitis, and hypersensitivity of the oral mucosa. We performed series of standard and dental patch tests for screening for contact allergy to dental materials, in accordance with International Contact Dermatitis Research Group guidelines. Positive extreme allergic reactions to mercury (+++) and amalgam (++) were seen at the patch site and caused a flare-up of the systemic erythematous reaction. Full recovery from BMS and complete remission of systemic dermatitis were achieved after the mercury tooth filling was removed. Mercury is thought to be an allergen implicated in BMS as well as in the systemic reactivation of allergic contact dermatitis. Patch testing with dental series seems to have greater sensitivity and relevance in BMS patients.


Assuntos
Alérgenos/efeitos adversos , Síndrome da Ardência Bucal/diagnóstico , Amálgama Dentário/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Compostos de Mercúrio/efeitos adversos , Idoso , Síndrome da Ardência Bucal/etiologia , Síndrome da Ardência Bucal/patologia , Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/patologia , Diagnóstico Diferencial , Feminino , Humanos , Testes do Emplastro
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...