RESUMO
Introduction: total kidney volume (TKV) increases in patients with autosomal dominant polycystic kidney disease (ADPKD), which perturbs anthropometric measurements. Objectives: the primary objectives were to investigate the accuracy of waist circumference (WC) and waist-to-hip ratio (WHR) for determining abdominal obesity in patients with ADPKD by comparison with magnetic resonance images. The secondary objectives were to investigate the associations of energy/macronutrient intake with WC and WHR. Methods: sixty patients with ADPKD were recruited from a nephrology outpatient clinic in this cross-sectional study. Main outcome measures were: TKV, total subcutaneous fat (TSF), total intraperitoneal fat (TIF), WC, WHR, body mass index (BMI), skinfold thickness (SFT), and energy/macronutrient intake. Results: mean age was 48.6 ± 11.3 years, 38 of 60 were women, median TKV was 1486 (IQR, 981-2847) mL. The patients classed as obese by the BMI had higher WC, TSF, TIF, and SFT than did non-obese; however, WHR was similar in obese and non-obese men. In the all-patients group, the WHR of obese and non-obese patients were also similar. TKV was positively correlated with WC and WHR in women, but not in men. In the multivariate analysis, TKV was an independent factor affecting WC and WHR in women. Dietary fat intake was similar in groups with and without abdominal obesity according to WC and WHR. Conclusions: in women with ADPKD, WC and WHR may not be accurate anthropometric measurements for evaluation of abdominal obesity; however, they may be associated with TKV (AU)
Introducción: el volumen total del riñón (TKV) crece en los pacientes con enfermedad poliquística autosómica dominante del riñón (ADPKD), la cual perturba las mediciones antropométricas. Objetivos: los principales objetivos eran investigar la precisión de la circunferencia de la cintura (WC) y del cociente cintura-cadera (WHR) para determinar la obesidad abdominal en pacientes con ADPKD en comparación con imágenes de resonancia magnética. Los objetivos secundarios eran investigar las asociaciones entre consumo de energia/macronutrientes y WC y WHR. Métodos: sesenta pacientes con ADPKD fueron reclutados por una clínica ambulatoria de nefrología en este estudio transversal. Las medidas resultantes principales fueron: TKV, grasa subcutánea total (TSF), grasa intraperitoneal total (TIF), WC, WHR, índice de masa corporal (BMI), espesor del pliegue cutáneo (SFT) y consumo de energía/macronutrientes. Resultados: la edad media era de 48,6 ± 11,3 años, 38 de 60 eran mujeres, la media de TKV era 1486 (IQR: 981-2847) mL. Los pacientes clasificados como obesos por el BMI tenían niveles más altos de WC, TSF, TIF and SFT que los no obesos; sin embargo, el WHR era similar en los hombres obesos y no obesos. En el grupo de todos los pacientes, el WHR de obesos y no obesos era también similar. El TKV se correlacionó positivamente con la WC y el WHR en las mujeres pero no en los hombres. En el análisis multivariado, el TKV era un factor independiente que afectaba a la WC y el WHR en las mujeres. La ingesta de grasas en la dieta era similar en los grupos con y sin obesidad abdominal de acuerdo con la WC y el WHR. Conclusiones: en las mujeres con ADPKD, la WC y el WHR quizá no son las medidas antropométricas más apropiadas para evaluar la obesidad abdominal; sin embargo, quizá esté relacionada con el TKV (AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Rim Policístico Autossômico Dominante/complicações , Obesidade Abdominal/complicações , Obesidade Abdominal/diagnóstico , Estudos Transversais , Índice de Massa Corporal , Estudos de Viabilidade , Fatores de Risco , Circunferência da Cintura , Relação Cintura-Quadril , Consumo de EnergiaRESUMO
Introduction: Introduction: total kidney volume (TKV) increases in patients with autosomal dominant polycystic kidney disease (ADPKD), which perturbs anthropometric measurements. Objectives: the primary objectives were to investigate the accuracy of waist circumference (WC) and waist-to-hip ratio (WHR) for determining abdominal obesity in patients with ADPKD by comparison with magnetic resonance images. The secondary objectives were to investigate the associations of energy/macronutrient intake with WC and WHR. Methods: sixty patients with ADPKD were recruited from a nephrology outpatient clinic in this cross-sectional study. Main outcome measures were: TKV, total subcutaneous fat (TSF), total intraperitoneal fat (TIF), WC, WHR, body mass index (BMI), skinfold thickness (SFT), and energy/macronutrient intake. Results: mean age was 48.6 ± 11.3 years, 38 of 60 were women, median TKV was 1486 (IQR, 981-2847) mL. The patients classed as obese by the BMI had higher WC, TSF, TIF, and SFT than did non-obese; however, WHR was similar in obese and non-obese men. In the all-patients group, the WHR of obese and non-obese patients were also similar. TKV was positively correlated with WC and WHR in women, but not in men. In the multivariate analysis, TKV was an independent factor affecting WC and WHR in women. Dietary fat intake was similar in groups with and without abdominal obesity according to WC and WHR. Conclusions: in women with ADPKD, WC and WHR may not be accurate anthropometric measurements for evaluation of abdominal obesity; however, they may be associated with TKV.
Introducción: Introducción: el volumen total del riñón (TKV) crece en los pacientes con enfermedad poliquística autosómica dominante del riñón (ADPKD), la cual perturba las mediciones antropométricas. Objetivos: los principales objetivos eran investigar la precisión de la circunferencia de la cintura (WC) y del cociente cintura-cadera (WHR) para determinar la obesidad abdominal en pacientes con ADPKD en comparación con imágenes de resonancia magnética. Los objetivos secundarios eran investigar las asociaciones entre consumo de energia/macronutrientes y WC y WHR. Métodos: sesenta pacientes con ADPKD fueron reclutados por una clínica ambulatoria de nefrología en este estudio transversal. Las medidas resultantes principales fueron: TKV, grasa subcutánea total (TSF), grasa intraperitoneal total (TIF), WC, WHR, índice de masa corporal (BMI), espesor del pliegue cutáneo (SFT) y consumo de energía/macronutrientes. Resultados: la edad media era de 48,6 ± 11,3 años, 38 de 60 eran mujeres, la media de TKV era 1486 (IQR: 981-2847) mL. Los pacientes clasificados como obesos por el BMI tenían niveles más altos de WC, TSF, TIF and SFT que los no obesos; sin embargo, el WHR era similar en los hombres obesos y no obesos. En el grupo de todos los pacientes, el WHR de obesos y no obesos era también similar. El TKV se correlacionó positivamente con la WC y el WHR en las mujeres pero no en los hombres. En el análisis multivariado, el TKV era un factor independiente que afectaba a la WC y el WHR en las mujeres. La ingesta de grasas en la dieta era similar en los grupos con y sin obesidad abdominal de acuerdo con la WC y el WHR. Conclusiones: en las mujeres con ADPKD, la WC y el WHR quizá no son las medidas antropométricas más apropiadas para evaluar la obesidad abdominal; sin embargo, quizá esté relacionada con el TKV.
Assuntos
Obesidade Abdominal , Rim Policístico Autossômico Dominante , Adulto , Índice de Massa Corporal , Estudos Transversais , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade Abdominal/complicações , Rim Policístico Autossômico Dominante/complicações , Fatores de Risco , Circunferência da Cintura , Relação Cintura-QuadrilRESUMO
OBJECTIVES: To assess the differences in the parameters that are metabolically related to cardiovascular diseases after weight loss in obese people with coronary artery diseases (CADs). METHODS: This study was conducted on 184 patients who were diagnosed with CADs in Istanbul University Cardiology Institute Hospital, Istanbul, Turkey. The levels of leptin, fibrinogen, homocysteine, high-sensitivity C-reactive protein (hs-CRP), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), fasting blood glucose and insulin, glycated hemoglobin, and uric acid of the obese patients who were put on calorie restricted diet were evaluated retrospectively and compared before and after weight loss. For comparison, non-obese control patients were also studied. Student's t-test and Chi-square test were used for the statistical analysis. Results: Levels of homocysteine, glycated hemoglobin, and leptin were significantly higher in the obese patients than in the non-obese patients. Diabetic obese patients with CADs lost (11.1%) and non-diabetic obese patients with CADs lost (10.5%) of their body weight in 6 months. The levels of cholesterol, LDL-C, and fibrinogen were significantly improved in both groups. Conclusion: The obese patients lost weight after being on calorie-restricted diets and showed significant improvement in the levels of cholesterol, LDL-C, fibrinogen. There was no significant difference in the levels of homocysteine, hs-CRP, and leptin before and after weight loss in both diabetic and non-diabetic obese patients.
