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1.
Vopr Virusol ; 40(2): 59-62, 1995.
Artigo em Russo | MEDLINE | ID: mdl-7762231

RESUMO

Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced the mortality rate, boosted the antiviral effect of reaferon proper, and led to virtually complete normalization of lipid peroxidation processes in the blood plasma and pulmonary tissues.


Assuntos
Vírus da Influenza A/efeitos dos fármacos , Interferon Tipo I/farmacologia , Peroxidação de Lipídeos/efeitos dos fármacos , Infecções por Orthomyxoviridae/metabolismo , Vitamina E/farmacologia , Animais , Antivirais/farmacologia , Interferon alfa-2 , Interferon-alfa , Camundongos , Infecções por Orthomyxoviridae/virologia , Proteínas Recombinantes
3.
Vopr Med Khim ; 34(6): 86-9, 1988.
Artigo em Russo | MEDLINE | ID: mdl-2467439

RESUMO

Lipid peroxidation as well as effects of various interferons (native, from fibroblasts of new born and adult animals) on the peroxidation were studied in blood plasma, erythrocytes, liver and kidney tissues of mice with viral infection. These interferons, simultaneously with antiviral action, exhibited the positive effect on lipid peroxidation, while the interferon from fibroblasts of newborns produced the side reactions. Simultaneous use of the interferon and alpha-tocopherol removed these side reactions.


Assuntos
Interferons/farmacologia , Peroxidação de Lipídeos/efeitos dos fármacos , Infecções por Orthomyxoviridae/metabolismo , Vitamina E/farmacologia , Animais , Vírus da Influenza A , Malondialdeído/sangue , Camundongos , Infecções por Orthomyxoviridae/terapia
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