RESUMO
A study was made of the modifying effect of a short-term induced hyperglycemia on the effectiveness of X- and neutron-radiation. It was shown that relative biological effectiveness of 6.0 MeV neutrons emitted by cyclotron U-120 was 2.33, in relation to standard X-radiation, as determined by the survival rate of irradiated HeLa cells. The short-term induced hyperglycemia increased the effectiveness of both X- and neutron-radiation; the changeability of the latter, however, was decreased as compared to X-radiation.
Assuntos
Sobrevivência Celular/efeitos da radiação , Glucose/farmacologia , Sobrevivência Celular/efeitos dos fármacos , Nêutrons Rápidos , Células HeLa/efeitos da radiação , Humanos , Eficiência Biológica RelativaRESUMO
Inoculation of white mice of varying body mass with pathologic strains of eastern and Venezuelan equine encephalomyelitis viruses and their attenuated variants (DNC-20/6 and No. 2621), promising as vaccine candidates, resulted in an increase of enzymatic activity and ultrastructural changes of isolated mitochondria from livers of the animals. The attenuated strains of the viruses were shown to induce temporary changes in both aspects of the study which became normal by the end of the study. There was a certain correlational dependence between the enzymatic activity and ultrastructural changes in isolated mitochondria associated with the use of energy in virus reproduction.