[Gastrointestinal function in patients with psoriasis concurrent with chronic opisthorchiasis before and after antiparasitic therapy].

The impact of antihelminthic therapy on gastrointestinal function was studied in 150 patients with psoriasis concurrent with chronic opisthorchiasis, 100 patients with psoriasis without helminthiasis, and 30 healthy individuals. A fractional study of gastric secretion was conducted in its both phases, by using histamine stimulation; carbohydrate absorption was investigated by the 5-g D-xylose test; fat absorption by the Kamer procedure; the bioelectrical activity of the small bowel was examined by electric enterography. These indices were followed up for 2-3 years. There were negative changes in gastric function in patients with 2-year persistent Opisthorchis invasion as compared with those recovered from this condition, in the latter, the pathological process becoming stable. After 3 years of the follow-up, negative changes were found in the values of fat and D-xylose absorption in patients with psoriasis as compared to the cured patients in whom the indices did not significantly become worse, However, in the cured patients, the absorption of fat and Dxylose did not normalize. The 3-year follow-up indicated that the patients with psoriasis concurrent with chronic opisthorchiasis had significantly decreased amplitudes of propulsive and non-propulsive waves (p < 0.05 and p < 0.01, respectively) while the latter indices were significantly increased in the cured patients (p < 0.01 and p < 0.05, respectively), but failing to reach the normal values. Effective dehelminthization in patients with psoriasis concurrent with chronic opisthorchiasis improved gastrointestinal function, making the course ofpsoriasis better (there were no exacerbations for 2 years).

[Clinical effectiveness of dehelmintization in patients with psoriasis accompanied by chronic opisthorchosis].

The purpose of the study was to prove the appropriateness of dehelmintization in patients with psoriasis accompanied by chronic opisthorchosis (CO). The authors examined 150 patients with psoriasis accompanied by CO, 100 patients having psoriasis without helminthiasis, 100 patients with psoriasis and 30 healthy individuals. Gastric secretion was evaluated by means of the fractional test (both phases) with histamine stimulation; other diagnostic procedures included carbohydrate absorption evaluation (5-gram D-Xylose absorption test), Kamer test of fat absorption and evaluation of small intestine bioelectric activity by means of electromyography. The patients were followed up within 2 to 3 years. The study found negative dynamics in the parameters of gastric secretion, fat and D-xylose absorption and small intestine bioelectric activity in patients with psoriasis and CO within the 2-3-year follow-up, while the group of dehelmintized patients displayed significant improvement of these parameters. Thus, effective dehelmintization allowed improvement of alimentary tract functional condition and the clinical course of psoriasis.

[Morphofunctional changes in gastrointestinal tract in patients with psoriasis accompanied by chronic opisthorchosis]. / Morfofunktsional'nye izmeneniia zheludochno-kishechnogo trakta pri sochetannom techenii psoriaza i khronicheskogo opistorkhoza.

The paper covers clinical, morphological and functional aspects of gastrointestinal tract condition in patients with psoriasis accompanied by chronic opisthorchosis (CO). The authors examined 150 patients with psoriasis accompanied by CO, 100 patients having psoriasis without helminthiasis, 100 patients with CO and 30 healthy people. The gastric secretion was evaluated by means of the fractional test (both phases) with histamine stimulation; other diagnostic procedures included carbohydrate absorption evaluation (5-gram D-Xylose absorption test) and Kamer test of fat absorption. The morphological condition of the gastric and intestinal mucosa was investigated by means of light and electron microscopy. The study revealed gastric secretory dysfunction and malabsorption in small and large intestines in patients with psoriasis and CO, clarified the relation between the duration of psoriasis and opisthorchosis and gastric secretory dysfunction and determined dependence of small intestine malabsorption on such factors as stage, severity, degree of skin involvement and duration of psoriasis. The authors also established interrelation between the above malfunctions and gastric and intestinal structural abnormalities.

[Morphofunctional alterations of the small intestine in patients with psoriasis and concomitant chronic opisthorchiasis]. / Morfofunktsional'nye izmeneniia tonkoi kishki u bol'nykh psoriazom v sochetanii s khronicheskim opistorkhozom.

To characterize the small intestine clinically and functionally in psoriasis combination with chronic opisthorhiasis, 60 patients were examined with this combination, 45 with psoriasis but no helminthosis, 30 patients with chronic opisthorchiasis and 15 healthy subjects. Small intestinal absorption was studied by fat and carbohydrates absorption; bioelectric small intestinal activity--by electroenterography. Absorption in the small intestine of patients with mixed pathology was impaired. Pathogenetic mechanisms of such impairment were the following: low amplitude of bioelectrical activity of the small intestine, subnormal concentration of bile acids in the vesical bile, defects in microbial biocenosis of the intestine, structural disorders of the upper small intestine. Abnormal absorption in the small intestine correlated with psoriasis clinical picture (stages, duration, size of the lesion, disease severity).

[Impaired intestinal absorption in patients with psoriasis concurrent with chronic opisthorchiasis]. / Narusheniia kishechnogo vsasyvaniia u bol'nykh psoriazom v sochetanii s khronicheskim opistorkhozom.

The study was undertaken to characterize small intestinal absorption in patients with psoriasis concurrent with chronic opisthorchiasis. Sixty patients with psoriasis concurrent with chronic opisthorchiasis, 45 patients with psoriasis without helminthiasis, and 15 healthy individuals were examined. The absorptive function of the small intestine was studied by the Kamer method (fat absorption) and with the D-xylose (5 g) test (carbohydrate absorption). Impaired small intestinal absorption of fats and carbohydrates was found in patients with psoriasis concurrent with chronic opisthorchiasis. There was a relationship of these disorders to the clinical picture of psoriasis (stages, duration, skin damage areas, severity).

[The treatment of alopecia areata with sinusoidal modulated currents]. / Lechenie gnezdnoi alopetsii sinusoidal'nymi modulirovannymi tokami.

The technique of alopecia areata treatment with sinusoidal modulated currents is simple and may be used on an outpatient basis. The Amplipul's-4 apparatus sensors have been placed in the cervical sympathetic node area. The current parameters have been as follows: P-1, III PP for 2-3 min, then IV PP for 2-3 min, modulation frequency 100-80 Hz and depth 50-75%, the pulse length within 2-4 sec provided the current strength is sufficient. The course of treatment included 10-12 sessions. Parallel with this physiotherapeutic modality, the patients were administered FiBS (a liman mud biogenic stimulant), vitamins B1 and B6, and andecalin. Clinical effect has been achieved in 46 of the 53 patients with a short duration of the disease. The authors' observations confirm the contribution of the sympathetic nervous system function to the genesis of alopecia.

Basic carriers of Trichophyton mentagrophytes var. gypseum in the Sverdlovsk region.

Tests for myococarriers were made on 4.297 wild small mammals. Clinical examinations only were carried out on 1,204 animals, both clinical and laboratory examinations on 3,093 animals. The suppurative form of trichophytosis was diagnosed in only one specimen of Microtus oeconomus out of 1,204 animals examined. T. ectothrix microides was found in the hair taken from the focus. T. mentagrophytes var. gypseum was obtained by culture on nutrient media. No clinical signs of mycosis were found in 3,093 animals, but seeding of the hair 175 animals (5.65%) on Sabouraud's agar with chlortetracycline and acti-dione produced cultures of T. mentagrophytes var. gypseum. The fungus was most frequently isolated in clinically healthy water rats, common field voles and field mice (Arvicola terrestris, Microtus arvalis, Apodemus agrarius). Mycocarriers were most frequently found among small mammals living in corn fields (5.9%), less frequently in water meadows (0.9) and sporadically in forests and bushes (0.1%). The possibility of bringing mycocarriers from the fields into inhabited areas during the transport of forage was reported.