Experimental rabies in cats: immune response and persistence of immunity.

Experimental rabies was studied in cats under defined conditions. A correlation between the virus dosage and the incubation period was established and results were compared with those published previously by others. the susceptibility of cats to rabies virus appears to be paradoxical. The persistence of the immunity induced by an inactivated rabies vaccine prepared form cell culture-propagated virus used in combination with feline panleukopenia vaccine, with or without adjuvant, was studied through severe virulent virus challenge. Complete protection was observed after more than 3 years following a single vaccination. A proposed vaccination schedule is discussed.

[Prevention of animal rabies by an attenuated monovalent or mixed vaccine]. / Prophylaxie de la rage animale (ou veterinaire) par un vaccin inactivé monovalent ou associé.

In view of the advantages and disadvantages of the different rabies vaccines, classified according to the production method of the virus and according to their nature - activated or inactivated - the choice of an activated vaccine produced on cell cultures is particularly justified for developing countries. The production of this type of vaccine, as well as the methods and results of the activity and innocuity controls are shown in detail. The interest of combined vaccines for certain developing countries, particularly the combined vaccine rabies/foot-and-mouth disease for ruminants, is stressed. The use of this type of vaccine on a vary large scale (more than 20 million doses up to this date) has given complete satisfaction. It should be noted that the same principles have been successfully applied to the realisation of a vaccine for human use, which can be administered before as well as after contamination.

Live and killed virus vaccines: their use against the respiratory diseases of cattle.

The respiratory diseases of cattle are due to a combination of different factors among which figures a viral infection. The antiviral vaccination, perfectly possible owing to associated killed vaccines and live virus, is thus a very important element which must enter into every general plan of prophylaxis. Moreover, these plans will concern bacterial infections, conditions of rearing, etc. We have demonstrated that it is possible to produce good immunity in calves and sheep using a trivalent killed vaccine (parainfluenza 3, adenovirus 3 and reovirus 1). Possible interference with antibodies of maternal origin makes the multiplication of vaccine injections desirable.