RESUMO
Conditioned avoidance response (CAR) tests were used to determine the effects of perinatal exposure to three neuroleptic drugs and an antineoplastic agent in mice. In one experiment, mice were given sc injections of haloperidol at 1.25 mg/kg.d or trifluoperazine at 12.5 mg/kg.d for 2 wk, starting when they were 4 d old. In additional groups, nursing dams were given haloperidol at 5 mg/kg.d or trifluoperazine at 25 mg/kg.d for 2 wk during lactation. CAR tests were begun when offspring were 40 d of age. No statistically significant evidence of impairment in the learning ability of any group was found. In a second experiment, hybrid male mice were treated with a single ip injection of triflupromazine at 50 mg/kg or triethylenemelamine at 0.2 mg/kg and were mated 2, 4, and 6 wk after dosing. The male offspring were tested for learning ability at 40 d of age. No statistically significant differences in CAR values were observed in offspring of triflupromazine-treated males. CAR values of offspring of triethylenemelamine-treated males mated 4 wk after dosing were significantly higher than those of controls.
Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Trietilenomelamina/farmacologia , Triflupromazina/farmacologia , Animais , Feminino , Lactação , Masculino , Camundongos , Camundongos Endogâmicos DBA , GravidezRESUMO
Buccal smears were analyzed for X chromatin in 1,000 newborn infants. The mean percentage of X chromatin in the 506 female infants was 39.5 (range 19-61) and in the 494 males 0.13 (range 0-3.0). Evaluation of the data comparing the percentage of X chromatin with caucasian and noncaucasian infants, the weight of the newborn, and the gestation time, indicated no significant differences within the male or female populations. A longitudinal study on 25 female infants for the first 4 days postpartum indicated a significant increase in the percentage of X chromatin in females.
Assuntos
Recém-Nascido , Cromatina Sexual , Cromossomos Sexuais , Peso ao Nascer , Feminino , Idade Gestacional , Humanos , Masculino , Fatores Sexuais , População BrancaAssuntos
Espermatogênese/efeitos dos fármacos , Espermatozoides/efeitos dos fármacos , Triflupromazina/toxicidade , Animais , Relação Dose-Resposta a Droga , Injeções Intraperitoneais , Masculino , Camundongos , Mutagênicos , Mutação , Triflupromazina/administração & dosagem , Triflupromazina/farmacologiaAssuntos
Aminas/farmacologia , Cicloexanos/farmacologia , Morte Fetal , Mutação/efeitos dos fármacos , Análise de Variância , Animais , Cruzamento , Cicloexilaminas/farmacologia , Feminino , Feto/efeitos dos fármacos , Genes Dominantes , Genes Letais , Masculino , Camundongos , Camundongos Endogâmicos , Gravidez , Trietilenomelamina/farmacologiaAssuntos
Biópsia , Exame de Medula Óssea , Animais , Citogenética , Fêmur , Cobaias , Métodos , RatosRESUMO
Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.
