[Effects of constant magnetic field on the growth and metastasizing of Lewis carcinoma in mice]. / Vliianie postoiannogo magnitnogo polia na rost i metastazirovanie kartsinomy L'iuis u myshei.

In mice with the metastasizing Lewis carcinoma the constant magnetic field (CMF) was studied for its effect on growth and metastatic process depending on the immobilization of animals. The results obtained show a decrease in the rate of the primary tumour growth and in the intensity of the metastatic process under the influence of CMF by incomplete immobilization. Complete immobilization eliminates the antimetastatic effects of the CMF.

[NAD participation in protecting DNA from damaging factors]. / Uchastie NAD v predokhranenii DNK ot povrezhdaiushchikh faktorov.

It was found that autolytic degradation of DNA during the isolation of nuclei under conditions of an in situ stimulated NAD biosynthesis is decreased to 2.5% in comparison with 5.2% in control. The increase in the NAD-pyrophosphorylase activity and the intranuclear content of NAD was almost 3-fold, whereas the amount of the acid-soluble DNA material was decreased 2-fold. The degree of DNA damage was increased up to 23% after induction with ethidium bromide. Under these conditions a preliminary in vivo stimulation of NAD biosynthesis by nicotinamide diminished the amount of the acid-soluble material. The levels of intranuclear NAD as well as the NAD-pyrophosphorylase and poly-(ADP-riboso)polymerase activities were essentially affected.