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1.
J Clin Periodontol ; 51(7): 874-883, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38426377

RESUMO

AIM: To assess the relationship between periodontitis and experimental pain tolerance. MATERIALS AND METHODS: Participants from the population-based seventh survey of the Tromsø Study with data on periodontitis were included (n = 3666, 40-84 years old, 51.6% women). Pain tolerance was assessed through (i) pressure pain tolerance (PPT) test with a computerized cuff pressure algometry on the leg, and (ii) cold-pressor tolerance (CPT) test where one hand was placed in circulating 3°C water. Cox proportional hazard regression was used to assess the association between periodontitis and pain tolerance adjusted for age, sex, education, smoking and obesity. RESULTS: In the fully adjusted model using the 2012 Centers for Disease Control/American Academy of Periodntology case definitions for surveillance of periodontitis, moderate (hazard ratio [HR] = 1.09; 95% confidence interval [CI]: 1.01, 1.18) and severe (HR = 1.25, 95% CI: 1.11, 1.42) periodontitis were associated with decreased PPT. Using the 2018 classification of periodontitis, having Stage II/III/IV periodontitis was significantly associated with decreased PPT (HR = 1.09; 95% CI: 1.01, 1.18) compared with having no or stage I periodontitis. There were no significant associations between periodontitis and CPT in fully adjusted models. CONCLUSIONS: Moderate and severe periodontitis was associated with experimental PPT.


Assuntos
Limiar da Dor , Periodontite , Humanos , Feminino , Masculino , Idoso , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Adulto , Limiar da Dor/fisiologia , Noruega/epidemiologia , Pressão , Medição da Dor
2.
Public Health Nutr ; 27(1): e27, 2024 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-38223974

RESUMO

OBJECTIVES: To explore dietary patterns in relation to periodontitis and number of teeth. DESIGN: A cross-sectional study. SETTING: We used data from the seventh survey of the Tromsø Study in Norway, 2015-2016. Three periodontitis groups were compared: (i) no periodontitis/slow bone loss; (ii) moderate bone loss; and (iii) rapid bone loss. Number of teeth was categorised as 25-28, 20-24 and ≤ 19. Dietary patterns were identified by principal component analysis. Multiple logistic regression was applied to examine associations between tertiles of dietary pattern scores and periodontitis, and between these same tertiles and number of teeth. PARTICIPANTS: 1487 participants (55·5 % women) aged 40-79 years who were free of major chronic diseases, attended an oral health examination and completed a FFQ. RESULTS: Four dietary patterns were identified, which explained 24 % of the total variability in food intake: fruit and vegetables, Westernised, meat/fish and potatoes, and refined grain and dessert. The fruit and vegetables pattern was inversely associated with periodontitis characterised by rapid bone loss when compared with no periodontitis/slow bone loss (OR tertile 3 v. 1 0·49, 95 % CI: 0·25, 0·98). Participants who were in the highest tertile of the refined grain and dessert pattern (tertile 3 v. 1) had 2·38- and 3·52-fold increased odds of having ≤ 19 than 20-24 and 25-28 teeth, respectively. CONCLUSION: Out of four identified dietary patterns, only the fruit and vegetables pattern was negatively associated with advanced periodontitis. A more apparent positive association was observed between the refined grain and dessert pattern and having fewer teeth (≤ nineteen teeth).


Assuntos
Dieta , Periodontite , Adulto , Animais , Humanos , Feminino , Masculino , Padrões Dietéticos , Estudos Transversais , Comportamento Alimentar , Verduras , Frutas , Periodontite/epidemiologia
3.
J Periodontol ; 94(11): 1324-1337, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37382343

RESUMO

BACKGROUND: The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high-sensitivity C-reactive protein (hs-CRP), and glycated hemoglobin (HbA1c) levels. METHODS: We included participants with periodontal examination (n = 3633, aged: 40-93 years) from the Tromsø Study seventh survey (2015-2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs (rs2288349, rs35474715, rs34023346, and rs10010325) in the sequence of the genes DNMT1, IDH2, TET1, and TET2. Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40-49 years were performed. RESULTS: In participants aged 40-49 years, homozygous carriage of minor A-allele of rs2288349 (DNMT1) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A-allele of rs10010325 (TET2) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G-allele of rs35474715 (IDH2) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A-allele of TET2 was associated with hs-CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028). CONCLUSIONS: In this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low-grade inflammation, and hyperglycemia.


Assuntos
Periodontite , Perda de Dente , Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Proteína C-Reativa/genética , Proteína C-Reativa/análise , Hemoglobinas Glicadas/genética , Perda de Dente/genética , Epigênese Genética/genética , Periodontite/genética , Periodontite/complicações , Polimorfismo de Nucleotídeo Único/genética , DNA , Oxigenases de Função Mista/genética , Proteínas Proto-Oncogênicas/genética
4.
J Periodontol ; 93(9): 1353-1365, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35621303

RESUMO

BACKGROUND: Few large-scale studies have investigated the association between periodontitis and cardiovascular risk estimated by risk assessment models; moreover, this association remains unexplored in never-smokers. We aimed to examine the relationship between periodontitis and cardiovascular risk in a Norwegian general population, with a focus on never-smokers and the impact of sex and age. METHODS: The present study included 2623 participants from the seventh survey of the Tromsø Study (Tromsø7, 2015-2016), aged 45-74 years, and without previous myocardial infarction or stroke. Periodontitis was defined according to the 2017 American Academy of Periodontology and the European Federation of Periodontology classification system. Participants were categorized by grade based on percentage bone loss/age as no periodontitis/Grade A (low progression rate) and Grade B/C (moderate-rapid progression rate). Low, medium, and high cardiovascular risk was defined based on the Norwegian risk model NORRISK 2. We used ordered logistic regression analysis to examine the association between periodontitis and cardiovascular risk, adjusting for education, toothbrushing frequency, body mass index, and diabetes. Subanalyses included stratification by sex and age (45-54, 55-64, 65-74 years) and a separate analysis of never-smokers. RESULTS: Periodontitis Grade B/C was associated with higher cardiovascular risk than no periodontitis/Grade A (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.75-2.61). This association was significant in both men and women, all age groups, and never-smokers. However, when never-smokers were stratified by age, the association remained significant only in those aged 65-74 years (OR, 3.00; 95% CI, 1.50-5.99). CONCLUSION: Periodontitis Grade B/C was associated with higher cardiovascular risk overall, and in never-smokers aged 65-74 years.


Assuntos
Doenças Cardiovasculares , Periodontite , Idoso , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/epidemiologia , Feminino , Humanos , Masculino , Razão de Chances , Periodontite/complicações , Periodontite/epidemiologia , Fatores de Risco , Fumar/epidemiologia
5.
Public Health Nutr ; 23(7): 1186-1200, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-30767841

RESUMO

OBJECTIVE: To investigate serum 25-hydroxyvitamin D (S-25(OH)D) concentration in a multi-ethnic population of northern Norway and determine predictors of S-25(OH)D, including Sami ethnicity. DESIGN: Cross-sectional data from the second survey of the Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations (the SAMINOR 2 Clinical Survey, 2012-2014). S-25(OH)D was measured by the IDS-iSYS 25-Hydroxy Vitamin DË¢ assay. Daily dietary intake was assessed using an FFQ. BMI was calculated using weight and height measurements. SETTING: Ten municipalities of northern Norway (latitude 68°-70°N). PARTICIPANTS: Males (n 2041) and females (n 2424) aged 40-69 years. RESULTS: Mean S-25(OH)D in the study sample was 64·0 nmol/l and median vitamin D intake was 10·3 µg/d. The prevalence of S-25(OH)D<30 nmol/l was 1·9 % and <50 nmol/l was 24·7 %. In sex-specific multivariable linear regression models, older age, blood sample collection in September-October, solarium use, sunbathing holiday, higher alcohol intake (in females), use of cod-liver oil/fish oil supplements, use of vitamin/mineral supplements and higher intakes of vitamin D were significantly associated with higher S-25(OH)D, whereas being a current smoker and obesity were associated with lower S-25(OH)D. These factors explained 21-23 % of the variation in S-25(OH)D. CONCLUSIONS: There were many modifiable risk factors related to S-25(OH)D, however no clear ethnic differences were found. Even in winter, the low prevalence of vitamin D deficiency found among participants with non-Sami, multi-ethnic Sami and Sami self-perceived ethnicity was likely due to adequate vitamin D intake.


Assuntos
Etnicidade , Deficiência de Vitamina D/epidemiologia , Vitamina D/administração & dosagem , Vitamina D/sangue , Adulto , Idoso , Estudos Transversais , Suplementos Nutricionais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Noruega/epidemiologia , Estado Nutricional , Fatores de Risco , Estações do Ano , Inquéritos e Questionários , Vitamina D/análogos & derivados , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/tratamento farmacológico , Deficiência de Vitamina D/etnologia , Vitaminas/administração & dosagem , Vitaminas/sangue
6.
BMC Public Health ; 19(1): 1632, 2019 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-31801498

RESUMO

BACKGROUND: Few population-based studies have assessed dietary behaviors in the rural multiethnic population of Northern Norway. The present study determined dietary patterns and investigated their association with Sami ethnicity, sociodemographic factors, and lifestyle factors in a multiethnic population in rural Northern Norway. METHODS: This cross-sectional study included 4504 participants of the SAMINOR 2 Clinical Survey (2012-2014) aged 40-69 years. All participants completed a lifestyle and food frequency questionnaire. Dietary patterns were determined using principal component analysis. Associations between food patterns and ethnicity, sociodemographic factors, and lifestyle factors were examined by multiple linear regression. RESULTS: Six dietary patterns were identified that accounted for 28% of the variability in food intake in the study sample: 'processed meat/westernized', 'fish/traditional', 'fruit/vegetables', 'reindeer/traditional', 'bread and sandwich spreads', and 'sweets and bakery goods'. The 'reindeer/traditional' pattern was most common among the inland Sami population. The 'fish/traditional' pattern was most common among costal multiethnic Sami and least common among inland Sami and among women independent of ethnicity. The 'fish/traditional' pattern was also positively associated with older age, high education level, small household size, and smoking. Adherence to the 'processed meat/westernized' pattern was lower among inland Sami than inland/coastal non-Sami; no ethnic differences in adherence to this pattern were found between costal multiethnic Sami and inland/coastal non-Sami. Unhealthy lifestyle factors, like low physical activity level and smoking, and younger age were mainly associated with the 'processed meat/westernized' pattern, whereas socioeconomic factors like low education, low gross annual household income, and large household size were related to the 'sweets and bakery goods' pattern. Male gender, low education level, and smoking were associated with the 'bread and sandwich spreads' pattern. The 'fruit/vegetables' pattern was characterized by healthy dietary choices and a health-conscious lifestyle, and was more common in women with a high education level and income. CONCLUSIONS: Adherence to the six identified dietary patterns was characterized by different sociodemographic and lifestyle factors. Ethnicity, in combination with geographical region of residence, was associated with dietary behaviors. This study provides knowledge that will be useful in future studies on dietary patterns related to chronic diseases in the rural population of Northern Norway.


Assuntos
Dieta/etnologia , Etnicidade/estatística & dados numéricos , Estilo de Vida/etnologia , População Rural/estatística & dados numéricos , Adulto , Fatores Etários , Idoso , Estudos Transversais , Exercício Físico , Feminino , Inquéritos Epidemiológicos , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Noruega/epidemiologia , Análise de Componente Principal , Fatores Sexuais , Fumar/etnologia , Fatores Socioeconômicos
7.
Nutr Res ; 64: 9-23, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30802727

RESUMO

The diet of the Indigenous Sami people has become more Westernized. The lack of population-based data on nutrient intake and nutritional adequacy, in combination with a high prevalence of obesity/metabolic syndrome among Sami, was the rationale behind the present study. We hypothesized that differences in nutrient intake between Sami and non-Sami populations may still exist but that these differences are likely small, especially with respect to nutritional contributors to cardiometabolic health. We used cross-sectional data from the SAMINOR 2 Clinical Survey (2012-2014) to study nutrient intake, assessed by a food frequency questionnaire, in 2743 non-Sami, 622 multiethnic Sami, and 1139 Sami participants aged 40-69 years. We applied quantile regression to study ethnic and inland/coastal regional differences. The median intake of most nutrients met the Estimated Average Requirements of the 2012 Nordic Nutrition Recommendations. However, the average intake of saturated fatty acids and sodium was higher, and average intake of fiber was lower than recommended, regardless of ethnicity and geographic region. The diet of Sami vs non-Sami participants and participants from the inland vs coastal region contained significantly more iron and vitamin B12. We found a number of statistically significant ethnic differences in nutrient intake; however, many of these differences were small (3%-4%). We observed no ethnic disparities in nutritional adequacy between Sami and non-Sami populations living in rural Northern Norway. Our results suggest that, compared to the non-Sami, the Sami have a dietary intake that may reduce their risk of iron deficiency but not their cardiometabolic risk.


Assuntos
Dieta , Etnicidade , Comportamento Alimentar , Estado Nutricional , Valor Nutritivo , Grupos Populacionais , População Rural , Adulto , Idoso , Anemia Ferropriva/etnologia , Doenças Cardiovasculares/etnologia , Estudos Transversais , Inquéritos sobre Dietas , Dieta Ocidental , Ingestão de Energia , Feminino , Humanos , Masculino , Síndrome Metabólica/etnologia , Pessoa de Meia-Idade , Noruega , Política Nutricional , Obesidade/etnologia
8.
Public Health Nutr ; 21(14): 2665-2677, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-29808789

RESUMO

OBJECTIVE: To estimate current food intake in the population of northern Norway and to investigate the impact of self-perceived Sami ethnicity and region of residence on food intake. DESIGN: The data are part of the second cross-sectional survey of the Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations (the SAMINOR 2 Clinical Survey, 2012-2014). Food intake was assessed by an FFQ. Ethnic and regional differences in food intake were studied by sex-specific, multivariable-adjusted quantile regression models. SETTING: Ten municipalities (rural northern Norway). SUBJECTS: Males (n 2054) and females (n 2450) aged 40-69 years (2743 non-Sami, 622 multi-ethnic Sami, 1139 Sami). RESULTS: The diet of Sami participants contained more reindeer meat, moose meat, food made with animal blood and freshwater fish; and contained less lean fish and vegetables. In the inland region, the consumption of reindeer meat was greatest in Sami participants, followed by multi-ethnic Sami participants and non-Sami participants, who had the lowest consumption (median 25, 12 and 8 g/d, respectively). Compared with the inland region, fish roe/liver intake was higher in the coastal region and lean fish intake was twice as high (41 and 32 g/d in males and females, respectively). CONCLUSIONS: When compared with non-Sami participants, those with solely self-perceived Sami ethnicity reported a significantly different intake of several foods, especially reindeer meat in the inland region. Multi-ethnic Sami tended to have similar diets to non-Sami. Residence in the coastal region predicted higher fish and roe/liver intake.


Assuntos
Comportamento Alimentar/etnologia , Inquéritos Epidemiológicos , Adulto , Idoso , Estudos Transversais , Ingestão de Energia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Noruega , População Rural
9.
Int J Circumpolar Health ; 73: 23859, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25147770

RESUMO

BACKGROUND: The prevalence of obesity and obesity-related conditions varies by population groups. Indigenous women of the circumpolar north are believed to be at high risk of obesity. OBJECTIVE: We studied, first the obesity prevalence in indigenous Arctic women, Nenets, compared to urban Russian women. Second, the association between obesity and cardiometabolic risk factors in the combined group of Nenets and Russian women. Third, ethnic differences in the association between obesity and cardiometabolic risk factors. DESIGN: Cross-sectional study performed in 2008-2009. SUBJECTS: 93 Nenets women, aged 19-77 (the indigenous village, the Nenets Autonomous Area) and 132 Russian women, aged 21-72 (Arkhangelsk city). Obesity was defined as body mass index (BMI)≥30 kg/m(2), waist circumference (WC)≥88 cm and or waist-to-hip ratio (WHR)≥0.85%. We assessed associations between obesity and cardiometabolic risk factors by linear and logistic regression models that included covariates of ethnicity, age, smoking and physical activity. We also tested for interaction between obesity measurements and ethnicity. RESULTS: Prevalence of obesity estimated through BMI, WC and WHR were 42.5, 45.3 and 41.9% in Nenets and 34.4, 46.4 and 29.5% in Russians, respectively, with no differences found. BMI, WC and WHR associated positively with triglycerides, fasting insulin and Homeostasis Model Assessment of Insulin Resistance index. In addition, BMI and WC correlated negatively with high-density lipoprotein cholesterol and positively with systolic blood pressure and apolipoprotein B/apoliporotein A-I ratio. WC explained significant variation in fasting glucose (FG) level. BMI predicted type 2 diabetes history. FG level associated strongly with ethnicity and was found to be higher in Russians. CONCLUSIONS: We found no differences in prevalence of obesity between Nenets and Russian females. Obesity was associated with cardiometabolic risk factors independently of ethnicity in the sample studied. There was no link between obesity measurements and ethnicity.


Assuntos
Índice de Massa Corporal , Doenças Cardiovasculares/etnologia , Etnicidade , Hiperlipidemias/etnologia , Obesidade/etnologia , Adulto , Idoso , Antropometria , Regiões Árticas/etnologia , Doenças Cardiovasculares/diagnóstico , Estudos Transversais , Feminino , Humanos , Hiperlipidemias/diagnóstico , Modelos Lineares , Modelos Logísticos , Pessoa de Meia-Idade , Obesidade/diagnóstico , Grupos Populacionais , Prevalência , Medição de Risco , População Rural , Federação Russa/epidemiologia , População Urbana , Circunferência da Cintura , Adulto Jovem
10.
Nutr Metab (Lond) ; 9(1): 51, 2012 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-22681916

RESUMO

BACKGROUND: Diets rich in omega-3 fatty acids and low in saturated fat were found beneficially associated with blood lipids and cardio-vascular health. Lean reindeer meet and local cold water white-fish species high in omega-3 are among the main sources of nutrients in the rural area of the Nenets Autonomous Okrug (NAO) in Russia and are not normally consumed by the urban population from the same region. The aims of the study were firstly, to compare serum lipid profiles of residents of urban (Arkhangelsk city) and rural (NAO) regions of Arkhangelsk County, and secondly, to investigate the effects of fish consumption on the predictor of cardiovascular events apolipoprotein (Apo) B/ApoA-I ratio in these populations. METHODS: A cross-sectional study conducted in Arkhangelsk County, Russia. Sample size of 249 adults: 132 subjects from Arkhangelsk city, aged 21-70 and 117 subject (87% Ethnic Nenets) from NAO, aged 18-69. RESULTS: We observed more favorable lipid levels in NAO compared to Arkhangelsk participants. Age-adjusted geometric means of ApoB/ApoA-I ratio were 1.02 and 0.98 in men and women from Arkhangelsk; 0.84 and 0.91 in men and women from NAO respectively. Age and consumption of animal fat were positively associated with ApoB/ApoA-I ratio in women (pooled samples from Arkhangelsk and NAO). Body mass index and low levels of physical activity were positively associated with ApoB/ApoA-I ratio in men (pooled samples from Arkhangelsk and NAO). Reported oily fish consumption was not significantly correlated with ApoB/ApoA-I ratio. CONCLUSION: The population sample from rural NAO, consisting largely of the indigenous Arctic population Nenets with healthier dietary sources, had a relatively less atherogenic lipid profile compared to the urban Arkhangelsk group. Fish consumption had no effect on apolipoproteins profile.

11.
Int J Circumpolar Health ; 70(1): 46-58, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21329575

RESUMO

OBJECTIVES: The urban Russian and the rural Indigenous populations in the Russian European North have different lifestyles, living conditions and food supplies. The objective of this study was to investigate and compare fish consumption in relation to the socio-economic characteristics of 2 communities in Arkhangelsk County. STUDY DESIGN: A cross-sectional study. METHODS: In total, 166 adults (83.1% women) from Arkhangelsk city and 134 adults (80.6% women) from the village of Nelmin-Nos (of which 88.9% are Indigenous people, Nenets), in the Nenets Autonomous Area (NAO), attended a health screening. The screening included a physical examination, blood sampling and a questionnaire. RESULTS: The populations studied had different socio-economic characteristics. In the rural NAO group, education levels were lower, the number of full-time employees was less, the percentage of persons with low monthly income was higher and the number of children per household was higher when compared to the Arkhangelsk group. The median total fish intake was 48.8 g/day for Arkhangelsk city and 27.1 g/day for Nelmin-Nos (p=0.009). Locally caught whitefish constituted a major part of the total fish consumption in Nelmin-Nos, while lean marine fish species were rarely eaten. Cod and cod-family fish species were often consumed by residents of Arkhangelsk city (p < 0.001). Fish consumption was positively related to monthly income. The frequency of fishing in the respondents from the Nelmin-Nos group predicted their fish consumption. CONCLUSIONS: Monthly income had a significant influence on fish intake in both study populations from Northern Russia. Fishing seems to be an important factor for predicting fish consumption in the residents of the rural NAO.


Assuntos
Ingestão de Energia/etnologia , Peixes , Grupos Populacionais/estatística & dados numéricos , População Rural/estatística & dados numéricos , Fatores Socioeconômicos , População Urbana/estatística & dados numéricos , Adolescente , Adulto , Idoso , Animais , Povo Asiático , Estudos Transversais , Feminino , Preferências Alimentares/etnologia , Humanos , Masculino , Pessoa de Meia-Idade , Sibéria , Inquéritos e Questionários , População Branca , Adulto Jovem
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