[The effect of a long-term administration of fluorine with food on the carcinogenesis and biochemical changes in the liver of rats]. / Vliianie prodolzhitel'nogo vvedeniia ftora s pishchei na kantserogenez i biokhimicheskie izmeneniia v pecheni krys

The effect of different amounts of fluorine in the ingested food (1.5 and 5 mg per 1 kg of body weight) on the development of tumours and biochemical changes in the liver of rats with carcinogenesis caused by their feeding on DAB was studied. With a long-term administration of fluorine in a dose of 1.5 mg/kg the appearance of macroscopically visible tumours in the liver proved less notable than with a lower dose or complete absence of fluorine. With carcinogenesis the rate of glycolysis in the liver of rats increases. A relationship between the inhibiting action of sodium fluoride on the glycolysis and changed activity of phosphofructokinase has been ascertained.