Lipid peroxidation induced by ultrasonication in Ehrlich ascitic tumor cells.

The mechanism of sonodynamic action in tumor cells is poorly investigated. It is known that ultrasound generates free radicals in phosphatidylcholine liposomes used as a membrane model. The participation of lipid peroxidation products in the mechanisms of physiological suppression of cell multiplication has been investigated for some tumor cells. In the present work ultrasound-induced lipid peroxidation in Ehrlich ascitic tumor cells was studied. Ultrasonication increased the level of lipid peroxidation quantified by the TBARS method in homogenates from Ehrlich ascitic tumor cells. Changes in the fatty acid composition of lipids from Ehrlich ascitic tumor cells irradiated by sonication were observed. TBARS production obtained by ultrasound was compared to TBARS production obtained by widely used chemical inductors. The free-radical processes evoked by ultrasound are of interest in antitumor therapy.

[Heterochromatin of the human Y chromosome as an example of selfish DNA]. / Geterkhromatin Y-khromosomy cheloveka kak primer égoisticheskoi DNK.

The nature of human Y-chromosome of Q-positive heterochromatic region is discussed. Both the authors data and those from literature show the existence of human population polymorphism with respect to the appearance of this region which consists of one or several bright fluorescent blocks. Their multiplication results probably from an unequal sister-strand crossing-over. Absence of these blocks has no visible phenotypic effect. Their extra multiplication affects the embryonal and possibly postnatal psychic development. It is supposed that Q-positive heterochromatin is an example of selfish DNA in the human genome.

[X-ray anatomic features of the skeleton in the 47, XYY syndrome]. / Rentgenoanatomicheskie osobennosti skeleta pri sindrome 47, XYY.

The data are represented on the examination of 11 men with 47, XYY karyotype, roengenography of some parts of their skeletals including. The result are compared with the data on investigation of 430 human males chosen from a population. This anomaly in the karyotype stipulates, in the skeletal formation, a tendency to high stature, a certain flattening in the head of the radiocarpal articulation, the kneepan and the distal contour of the femoral bone. Nearly in a half of all observations valgus deviation of the ulnar articulation was somewhat increased, in 3 cases--inhibition of some synostoses in the growth zones of the extremities was noted. A supposition is made that in males the insidence of cleft in sesamoid bones in the lower extremities is increased in the presence of the extra Y-chromosome.

[Schizophrenic and schizophrenic-like manifestations in syndrome 47, XYY]. / Shizofrenicheskie i shizofrenopodobnye proiavleniia pri sindrome 47, XYY

The authors examined 4446 patients in mental hospitals. Among these patients 15 displayed the 47 XYY syndrome and 3 with mosaicism 46 XY/47 XYY. A study of these patients showed that in 5 cases they were qualified as schizophrenic. They were study died from 2-5 years. In 4 cases the diagnosis of schizophrenia was not confirmed. In one case the authors diagnosed the disease as an atypical form of schizophrenia. The clinical traits of the disease in this case are associated with a supplementary Y somasomia.