[EEG study of the anxiolytic effect of scopolamine]. / EEG-issledovanie anksioliticheskogo éffekta skopolamina.

Effect of the central M-cholinolytic scopolamine on spatial organization of the rat brain electrical activity was studied under conditions of high and low emotional-stress responses. The EEG changes were estimated by 840 parameters. A possibility of the EEG discrimination by means of interstrain differences in responses to scopolamine, was shown. A more obvious decrease in spectral power and potentials coherence was revealed in Maudsley Reactive rats (MR) as compared with the Maudsley Nonreactive rats (MNRA), in parieto-temporal and occipital areas of the right hemisphere, and the reverse interrelationship occurred in the anterior parts of the right and posterior parts of the left hemisphere. These findings suggest some specifics in the spatial distribution of the maximum scopolamine action foci depending on the initial emotional level. Changes occurring under the scopolamine effect in different EEG frequency bands are different in the MR and the MNRA rats. The findings are discussed in respect to the EEG indices of anxiolytic component of cholinergic regulation of the brain activity.

[The effect of scopolamine on the spatial organization of rat cortical potentials]. / Vliianie skopolamina na prostranstvennuiu organizatsiiu potenstialov kory golovnogo mozga krys.

The influence of scopolamine (1 mg/kg, i.p.) on the spatial organization of the neocortical electrical activity was studied in rats. A decrease in the spectral power and coherence of brain potentials in the range of the dominant theta-rhythm peak (6.00-7.25 Hz) and their increase in the adjacent low-frequency band were observed. Both indices were decreased in the wide beta band (19.00-30.00 Hz). The described changes took place over the whole areas of the right hemisphere and parieto-temporal region of the left hemisphere. The obtained results are discussed with respect to the role of the cholinergic brain system in the higher nervous activity.

[The spatial ordering of the brain electrical processes as an index of its functional organization]. / Prostranstvennaia uporiadochennost' élektricheskikh protsessov mozga kak pokazatel' ego funktsional'noi organizatsii.

Analysis of constraints, which are imposed on correctness of conclusions drawn from the studies of the spectrum-correlation model of cortex electrical activity, and necessity of enlarging interaction forms which have to be studied, brought to development a new index for estimating spatial order of cortex electrical processes. This index and the technique were called "multiple entropy" (ME). The algorithm of calculating ME and its properties are discussed. The results of studying spatial structure of cortex electrical processes by estimating their spatial synchronization and ME were compared. It was shown that these approaches complemented each other. Using both these techniques in combination gives more complete picture of integration of cortex processes.

Peptidergic modulation of learning a motoric food-procuring conditioned reflex skill.

Experimental data are presented which were obtained during an investigation of the influence of various doses of a synthetic heptapeptide based on tafcine on the learning of a complex instrumental skill in dogs. The effectiveness of the intranasal application of the peptide in the early stages of learning was demonstrated, as was its capacity to restore the lost skill. The vegetative support of the motoric reactions during the modulation of the learning by the peptide was investigated.

[The peptidergic modulation of learning a motor food-acquiring conditioned-reflex habit]. / Peptidergicheskaia moduliatsiia obucheniia dvigatel'nomu pishchedobyvatel'nomu uslovnoreflektornomu navyku.

The experimental data were given obtained at studying the influence of different dozes of synthetic heptapeptide (on tafcine basis) on learning to complex instrumental habit in dogs. Effectiveness of intranasal application of peptide on earlier stages of learning and also its ability to restore the lost habit was shown. Vegetative ensuring of learning at its modulation by peptide was studied.