RESUMO
Therapeutic apheresis in children is limited by technical considerations, such as circuit blood volume, venous access and hemodynamic instability. Here we report our experience with 310 plasma-filtration sessions in 44 children (aged 9 months-17 years). We used a miniaturized circuit with a unipuncture technique and a "balancing system" which assured a permanent fluid equilibrium. This procedure is well adapted to children and always made pediatric plasma exchange therapy easier and safer. The more common indications remain Guillain-Barré syndrome and acute severe glomerular diseases.
Assuntos
Troca Plasmática/métodos , Plasma , Ultrafiltração/métodos , Adolescente , Criança , Pré-Escolar , Humanos , LactenteRESUMO
A pharmacokinetic study was performed in plasma and cerebrospinal fluid (CSF) of patients suffering from brain tumors to describe the disposition of methotrexate. An open three-compartment model was developed to fit together the data obtained in plasma and CSF. The pharmacokinetic parameters obtained by the model agreed with those obtained with classical analysis and the fitting correctly depicted the plasma and CSF concentration decays. According to the results, such a model could be applied to other anticancer drugs.
Assuntos
Metotrexato/farmacocinética , Adolescente , Neoplasias Encefálicas/tratamento farmacológico , Criança , Pré-Escolar , Feminino , Humanos , Infusões Intravenosas , Masculino , Metotrexato/sangue , Metotrexato/líquido cefalorraquidiano , Modelos BiológicosRESUMO
Leigh's disease is a subacute metabolic encephalopathy characterized by bilateral and symmetrical lesions of basal ganglia, mid-brain and pons. Lesions are related to an abnormal pyruvate metabolism which mechanisms remain still uncertain. This disease is rare and the authors present a case with complete anatomic study.
Assuntos
Encefalopatias Metabólicas/patologia , Encéfalo/patologia , Doença de Leigh/patologia , Miocárdio/patologia , Encéfalo/metabolismo , Pré-Escolar , Humanos , Masculino , Mitocôndrias Cardíacas/ultraestrutura , Miocárdio/ultraestrutura , Piruvatos/metabolismo , Ácido PirúvicoRESUMO
The marginal glossectomies may be extended without disadvantage to the whole margin of the tongue and give a reduction in the volume of the tongue on the margins and, in some cases, before.
