Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Dermatol Ther ; 35(6): e15464, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35306720

RESUMO

Generalized erythrodermic psoriasis (GEP) is a rare and potentially life-threatening variant of psoriasis. Possible triggers that have been identified to date include poorly controlled psoriasis, medications, abrupt discontinuation of anti-psoriatic treatment, and underlying systemic illnesses. However, vaccines have rarely been reported to exacerbate GEP. Herein, we report two unique cases with GEP exacerbated following a dose of the BNT162b2 mRNA vaccine for COVID-19 (as their second dose, the first being the mRNA-1273 vaccine). Based on our observations and a literature review, vaccination was considered the most likely trigger of GEP due to the close temporal relationship between the second vaccination and the onset of GEP.


Assuntos
Vacina BNT162 , COVID-19 , Psoríase , Vacina de mRNA-1273 contra 2019-nCoV , Vacina BNT162/efeitos adversos , COVID-19/prevenção & controle , Humanos , Psoríase/induzido quimicamente , SARS-CoV-2 , Vacinação/efeitos adversos
2.
Am J Med Genet A ; 188(1): 377-381, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34453476

RESUMO

Cantú syndrome (CS) is an extremely rare autosomal dominant hereditary disease characterized by congenital hypertrichosis, distinct coarse facial features, cardiac defects, and other abnormalities in the skeletal and neurological systems. At present, cases with pathognomonic clinical manifestations are increasingly confirmed by genetic analysis. Two causative genes for CS are the well-known ABCC9 and the more rarely reported KCNJ8. Here, we report three Vietnamese children with CS, confirmed through genetic testing, presenting de novo ABCC9 mutations. The patients shared some common clinical manifestations, including congenital hypertrichosis, distinctive facial features, and a history of polyhydramnios during pregnancy. Concerning the various cardiac and neurological problems in the lifetime of patients with CS, an accurate diagnosis and appropriate management, especially genetic counseling, should be clinically applied in CS. Thus, our findings might modestly contribute to the global CS data, providing practical insights into CS manifestations.


Assuntos
Hipertricose , Osteocondrodisplasias , Cardiomegalia/genética , Criança , Humanos , Hipertricose/diagnóstico , Hipertricose/genética , Osteocondrodisplasias/diagnóstico , Osteocondrodisplasias/genética , Vietnã
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...