Primary adenocarcinoma of the fallopian tube as an incidental finding during surgery in a postmenopausal patient with unspecific pelvic pain.

Primary fallopian tube carcinoma (PFTC) is a rare gynecologic neoplasm and is usually diagnosed late and presents classically with a characteristic group of symptoms. We describe a case of a 76-year-old woman who underwent TVS requested by the family physician due to unspecific pelvic pain. An adnexal mass was found with morphology associated with high levels of CA125 suggestive of a malignant tumor. During laparotomy, a mass located in the left tube was found. Histopathology confirmed PFTC. Total hysterectomy, salpingo-oophorectomy and adjuvant chemotherapy with carboplatin/paclitaxel were performed. The patient has not yet presented any signs of recurrence.

Vaginal hysterectomy for correcting genital prolapse. Long-term evaluation.

OBJECTIVE: To determine whether a transvaginal hysterectomy with anterior and posterior repair is effective in the long term in treating uterovaginal prolapse and stress urinary incontinence (SUI). STUDY DESIGN: Seventy-four patients subjected to vaginal hysterectomy for the treatment of severe genital prolapse, on average five years before the study, were contacted by letter for evaluation. Four of these patients had died, and 47 (67.1%) responded to the letter. The mean age of the patients at the time of reevaluation was 66.1 +/- 10.6 years, and mean parity was 6.6 deliveries. RESULTS: All patients but two presented some degree of genital prolapse at the time of reevaluation, with three cases of total vaginal vault prolapse. White patients (87.2%) predominated over African (black) patients (12.8%). SUI associated with prolapse persisted in 14 of the 20 patients, and 6 others had this complaint after surgical correction (22.2% of previously continent patients). CONCLUSION: The rate of unsuccessful surgical correction of severe genital prolapse was very high (95.7%), and cure of SUI was low (30%), with SUI actually arising after surgical correction in 25% of continent patients. In addition to parity, there seems to be a racial factor linked to the onset and maintenance of this pathology, with a higher prevalence among white patients.

Multiple uterine leiomyomas: cytogenetic analysis.

Six uterine leiomyomas were studied cytogenetically. The material comprised two uterine myomas from one patient and four tumors from a second patient. In all cases the modal number was 46. The clonal numerical alterations were monosomies involving chromosomes X, 6, 8, 13, 19, and trisomy of 12. The only clonal structural alteration was der(11)t(10;11)(q11;q24). Although two monosomies (X and 8) were shared by two of four leiomyomas from the same uterus, the results suggested that each leiomyoma was the product of a separate clonal development.

Mammary epithelial hyperplasias: alterations related solely to proliferation?

The cytogenetic analysis of five mammary epithelial hyperplasias is reported. Only two cases had clonal chromosome alterations. Structural alterations involved chromosomes 1 and 5. Numerical alterations involved chromosomes X, 1, 6, 9, and 19. In four cases, the modal number was in the diploid range, and one case was tetraploid. The study of benign proliferations and their comparison with the chomosome alterations of their malignant counterparts could lead to a better understanding of the genes acting solely in cell proliferation and those that cause these cells to undergo malignant transformation and to become invasive.

Cytogenetic study of benign mesenchymal neoplasias

Três leiomiomas uterinos humanos foram cultivados e analisados citogeneticamente. Embora o número modal estivesse na regiäo diplóide, todas as neoplasias apresentaram hiperdiploidia. Um dos casos apresentou 27% das células na regiäo hipertriplóide-hipertraplóide. As alteraçöes numéricas mais frequentes foram monossomias envolvendo os cromossomos 20 (3 casos) e 2, 7, 18 (2 casos cada) e um caso apresentou polissomias de todos os cromossomos (variando de trissomia a pentassomia). Um caso apresentou um grande anel cromossômico semelhante ao cromossomo 1 e um marcador com o rearranjo: t(2;12) (2qter - 2q14-15 - 12 pter). O significado das alteraçöes citogenéticas em tumores benignos ainda está por ser determinada