Prediction of soft tissue deformations after CMF surgery with incremental kernel ridge regression.

Facial soft tissue deformation following osteotomy is associated with the corresponding biomechanical characteristics of bone and soft tissues. However, none of the methods devised to predict soft tissue deformation after osteotomy incorporates population-based statistical data. The aim of this study is to establish a statistical model to describe the relationship between biomechanical characteristics and soft tissue deformation after osteotomy. We proposed an incremental kernel ridge regression (IKRR) model to accomplish this goal. The input of the model is the biomechanical information computed by the Finite Element Method (FEM). The output is the soft tissue deformation generated from the paired pre-operative and post-operative 3D images. The model is adjusted incrementally with each new patient's biomechanical information. Therefore, the IKRR model enables us to predict potential soft tissue deformations for new patient by using both biomechanical and statistical information. The integration of these two types of data is critically important for accurate simulations of soft-tissue changes after surgery. The proposed method was evaluated by leave-one-out cross-validation using data from 11 patients. The average prediction error of our model (0.9103mm) was lower than some state-of-the-art algorithms. This model is promising as a reliable way to prevent the risk of facial distortion after craniomaxillofacial surgery.

Estimating patient-specific and anatomically correct reference model for craniomaxillofacial deformity via sparse representation.

PURPOSE: A significant number of patients suffer from craniomaxillofacial (CMF) deformity and require CMF surgery in the United States. The success of CMF surgery depends on not only the surgical techniques but also an accurate surgical planning. However, surgical planning for CMF surgery is challenging due to the absence of a patient-specific reference model. Currently, the outcome of the surgery is often subjective and highly dependent on surgeon's experience. In this paper, the authors present an automatic method to estimate an anatomically correct reference shape of jaws for orthognathic surgery, a common type of CMF surgery. METHODS: To estimate a patient-specific jaw reference model, the authors use a data-driven method based on sparse shape composition. Given a dictionary of normal subjects, the authors first use the sparse representation to represent the midface of a patient by the midfaces of the normal subjects in the dictionary. Then, the derived sparse coefficients are used to reconstruct a patient-specific reference jaw shape. RESULTS: The authors have validated the proposed method on both synthetic and real patient data. Experimental results show that the authors' method can effectively reconstruct the normal shape of jaw for patients. CONCLUSIONS: The authors have presented a novel method to automatically estimate a patient-specific reference model for the patient suffering from CMF deformity.

Estimating anatomically-correct reference model for craniomaxillofacial deformity via sparse representation.

The success of craniomaxillofacial (CMF) surgery depends not only on the surgical techniques, but also upon an accurate surgical planning. However, surgical planning for CMF surgery is challenging due to the absence of a patient-specific reference model. In this paper, we present a method to automatically estimate an anatomically correct reference shape of jaws for the patient requiring orthognathic surgery, a common type of CMF surgery. We employ the sparse representation technique to represent the normal regions of the patient with respect to the normal subjects. The estimated representation is then used to reconstruct a patient-specific reference model with "restored" normal anatomy of the jaws. We validate our method on both synthetic subjects and patients. Experimental results show that our method can effectively reconstruct the normal shape of jaw for patients. Also, a new quantitative measurement is introduced to quantify the CMF deformity and validate the method in a quantitative approach, which is rarely used before.

Automated bone segmentation from dental CBCT images using patch-based sparse representation and convex optimization.

PURPOSE: Cone-beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. Accurate segmentation of CBCT image is an essential step to generate three-dimensional (3D) models for the diagnosis and treatment planning of the patients with CMF deformities. However, due to the poor image quality, including very low signal-to-noise ratio and the widespread image artifacts such as noise, beam hardening, and inhomogeneity, it is challenging to segment the CBCT images. In this paper, the authors present a new automatic segmentation method to address these problems. METHODS: To segment CBCT images, the authors propose a new method for fully automated CBCT segmentation by using patch-based sparse representation to (1) segment bony structures from the soft tissues and (2) further separate the mandible from the maxilla. Specifically, a region-specific registration strategy is first proposed to warp all the atlases to the current testing subject and then a sparse-based label propagation strategy is employed to estimate a patient-specific atlas from all aligned atlases. Finally, the patient-specific atlas is integrated into a maximum a posteriori probability-based convex segmentation framework for accurate segmentation. RESULTS: The proposed method has been evaluated on a dataset with 15 CBCT images. The effectiveness of the proposed region-specific registration strategy and patient-specific atlas has been validated by comparing with the traditional registration strategy and population-based atlas. The experimental results show that the proposed method achieves the best segmentation accuracy by comparison with other state-of-the-art segmentation methods. CONCLUSIONS: The authors have proposed a new CBCT segmentation method by using patch-based sparse representation and convex optimization, which can achieve considerably accurate segmentation results in CBCT segmentation based on 15 patients.

Automated segmentation of CBCT image using spiral CT atlases and convex optimization.

Cone-beam computed tomography (CBCT) is an increasingly utilized imaging modality for the diagnosis and treatment planning of the patients with craniomaxillofacial (CMF) deformities. CBCT scans have relatively low cost and low radiation dose in comparison to conventional spiral CT scans. However, a major limitation of CBCT scans is the widespread image artifacts such as noise, beam hardening and inhomogeneity, causing great difficulties for accurate segmentation of bony structures from soft tissues, as well as separating mandible from maxilla. In this paper, we presented a novel fully automated method for CBCT image segmentation. In this method, we first estimated a patient-specific atlas using a sparse label fusion strategy from predefined spiral CT atlases. This patient-specific atlas was then integrated into a convex segmentation framework based on maximum a posteriori probability for accurate segmentation. Finally, the performance of our method was validated via comparisons with manual ground-truth segmentations.

Incremental kernel ridge regression for the prediction of soft tissue deformations.

This paper proposes a nonlinear regression model to predict soft tissue deformation after maxillofacial surgery. The feature which served as input in the model is extracted with finite element model (FEM). The output in the model is the facial deformation calculated from the preoperative and postoperative 3D data. After finding the relevance between feature and facial deformation by using the regression model, we establish a general relationship which can be applied to all the patients. As a new patient comes, we predict his/her facial deformation by combining the general relationship and the new patient's biomechanical properties. Thus, our model is biomechanical relevant and statistical relevant. Validation on eleven patients demonstrates the effectiveness and efficiency of our method.

Zygomatic implants--protocol for immediate occlusal loading: a preliminary report.

PURPOSE: To investigate the modified protocol for immediate occlusal loading of the zygomatic implants and to report the preliminary results of this modified protocol. MATERIALS AND METHODS: Four male patients and 1 female patient with edentulous maxillae were consecutively treated with the zygomatic implants under general anesthesia. All 5 patients were examined by computed tomography and investigated by the SimPlant software (Materialise NV, Leuven, Belgium). Based on the virtual surgical plans, mucosa-supported surgical guides were manufactured by rapid prototyping technique before implant operation. Instead of making a Le Fort I Osteotomy incision or a crestal incision, buccal vestibular incision was used to expose the surgical site for the zygomatic implant osteotomy and placement. Three patients had their remaining upper teeth removed on the same day as implant placement. One patient had undergone simultaneous placement of upper and lower implants followed by immediate loading. The immediate loading protocol was a 2-stage method using a customized provisional fixed prosthesis. RESULTS: Ten zygomatic implants and 20 normal implants were installed in these 5 patients. These 5 patients were reviewed regularly for 6 to 10 months after immediate loading. The zygomatic implants were considered to be successful when they were asymptomatic with no clinical mobility and no sign of infection. All the zygomatic implants and normal implants were investigated individually after removing the provisional prosthesis and were found to be clinically stable and asymptomatic. CONCLUSION: According to our observation, immediate occlusal loading of the zygomatic implants has a very good potential for success, as much as immediate occlusal loading of normal dental implants. The surgical placement of the zygomatic implant is simplified and facilitated by making use of the computer-assisted planning and the rapid-prototyping surgical guides.

Surgical rehabilitation of the upper limb in quadriplegia.

Fifteen quadriplegic (tetraplegic) patients from the Spinal Injuries Unit of the Austin Hospital have had surgery to improve function in 17 of their upper limbs. Changes in strength, function, subjective ratings and the influence on 198 activities of daily living are reviewed. The posterior third of the deltoid muscle was transferred into 8 triceps tendons to provide active elbow extension in seven patients. Six patients had transfers of forearm muscles to provide grasp and lateral pinch or active extension of wrist and fingers. Other operations included transfer of the latissimus dorsi to the forearm producing elbow flexion, medial advancement of the anterior deltoid origin improving shoulder control (an operation which has not been described previously), and tenodesis for stabilizing the wrist. The objective results were satisfactory in 12 patients. Eleven patients had either good or excellent subjective results. The maximum force of active elbow extension achieved was 6.8 kg and the peak grip strength reached was 10.5 kg. Six patients achieved subjective results higher than would have been expected from objective assessment. All patients benefited in some way, 13 patients felt that surgery was worthwhile and no patient lost appreciable function. The results of this series indicate that upper limb surgery has a definite place in rehabilitation of the quadriplegic patient. Improved surgical technique may reduce the time required for postoperative rehabilitation and thus make these procedures feasible for a larger number of patients.