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1.
Sci Rep ; 5: 16837, 2015 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-26593245

RESUMO

Human population movements currently challenge malaria elimination in low transmission foci in the Greater Mekong Subregion. Using a mixed-methods design, combining ethnography (n = 410 interviews), malariometric data (n = 4996) and population surveys (n = 824 indigenous populations; n = 704 Khmer migrants) malaria vulnerability among different types of mobile populations was researched in the remote province of Ratanakiri, Cambodia. Different structural types of human mobility were identified, showing differential risk and vulnerability. Among local indigenous populations, access to malaria testing and treatment through the VMW-system and LLIN coverage was high but control strategies failed to account for forest farmers' prolonged stays at forest farms/fields (61% during rainy season), increasing their exposure (p = 0.002). The Khmer migrants, with low acquired immunity, active on plantations and mines, represented a fundamentally different group not reached by LLIN-distribution campaigns since they were largely unregistered (79%) and unaware of the local VMW-system (95%) due to poor social integration. Khmer migrants therefore require control strategies including active detection, registration and immediate access to malaria prevention and control tools from which they are currently excluded. In conclusion, different types of mobility require different malaria elimination strategies. Targeting mobility without an in-depth understanding of malaria risk in each group challenges further progress towards elimination.


Assuntos
Anopheles/parasitologia , Erradicação de Doenças/organização & administração , Insetos Vetores/parasitologia , Malária Falciparum/epidemiologia , Malária Vivax/epidemiologia , Migrantes/estatística & dados numéricos , Animais , Antimaláricos/uso terapêutico , Artemisininas/uso terapêutico , Artesunato , Camboja , Cloroquina/uso terapêutico , Inquéritos Epidemiológicos , Humanos , Malária Falciparum/tratamento farmacológico , Malária Falciparum/parasitologia , Malária Falciparum/transmissão , Malária Vivax/tratamento farmacológico , Malária Vivax/parasitologia , Malária Vivax/transmissão , Mefloquina/uso terapêutico , Plasmodium falciparum/efeitos dos fármacos , Plasmodium falciparum/crescimento & desenvolvimento , Plasmodium vivax/efeitos dos fármacos , Plasmodium vivax/crescimento & desenvolvimento , Migrantes/psicologia
2.
Sci Rep ; 5: 16847, 2015 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-26574048

RESUMO

In Cambodia, despite an impressive decline in prevalence over the last 10 years, malaria is still a public health problem in some parts of the country. This is partly due to vectors that bite early and outdoors reducing the effectiveness of measures such as Long-Lasting Insecticidal Nets. Repellents have been suggested as an additional control measure in such settings. As part of a cluster-randomized trial on the effectiveness of topical repellents in controlling malaria infections at community level, a mixed-methods study assessed user rates and determinants of use. Repellents were made widely available and Picaridin repellent reduced 97% of mosquito bites. However, despite high acceptability, daily use was observed to be low (8%) and did not correspond to the reported use in surveys (around 70%). The levels of use aimed for by the trial were never reached as the population used it variably across place (forest, farms and villages) and time (seasons), or in alternative applications (spraying on insects, on bed nets, etc.). These findings show the key role of human behavior in the effectiveness of malaria preventive measures, questioning whether malaria in low endemic settings can be reduced substantially by introducing measures without researching and optimizing community involvement strategies.


Assuntos
Erradicação de Doenças/métodos , Repelentes de Insetos , Malária/prevenção & controle , Administração Tópica , Animais , Camboja , Estudos Transversais , Culicidae/efeitos dos fármacos , Erradicação de Doenças/normas , Humanos , Repelentes de Insetos/toxicidade , Insetos Vetores/efeitos dos fármacos , Saúde Pública , Inquéritos e Questionários
3.
Malar J ; 14: 165, 2015 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-25908498

RESUMO

BACKGROUND: In certain regions in Southeast Asia, where malaria is reduced to forested regions populated by ethnic minorities dependent on slash-and-burn agriculture, malaria vector populations have developed a propensity to feed early and outdoors, limiting the effectiveness of long-lasting insecticide-treated nets (LLIN) and indoor residual spraying (IRS). The interplay between heterogeneous human, as well as mosquito behaviour, radically challenges malaria control in such residual transmission contexts. This study examines human behavioural patterns in relation to the vector behaviour. METHODS: The anthropological research used a sequential mixed-methods study design in which quantitative survey research methods were used to complement findings from qualitative ethnographic research. The qualitative research existed of in-depth interviews and participant observation. For the entomological research, indoor and outdoor human landing collections were performed. All research was conducted in selected villages in Ratanakiri province, Cambodia. RESULTS: Variability in human behaviour resulted in variable exposure to outdoor and early biting vectors: (i) indigenous people were found to commute between farms in the forest, where malaria exposure is higher, and village homes; (ii) the indoor/outdoor biting distinction was less clear in forest housing often completely or partly open to the outside; (iii) reported sleeping times varied according to the context of economic activities, impacting on the proportion of infections that could be accounted for by early or nighttime biting; (iv) protection by LLINs may not be as high as self-reported survey data indicate, as observations showed around 40% (non-treated) market net use while (v) unprotected evening resting and deep forest activities impacted further on the suboptimal use of LLINs. CONCLUSIONS: The heterogeneity of human behaviour and the variation of vector densities and biting behaviours may lead to a considerable proportion of exposure occurring during times that people are assumed to be protected by the distributed LLINs. Additional efforts in improving LLIN use during times when people are resting in the evening and during the night might still have an impact on further reducing malaria transmission in Cambodia.


Assuntos
Culicidae/fisiologia , Habitação , Insetos Vetores/fisiologia , Malária/transmissão , Controle de Mosquitos/métodos , Adolescente , Adulto , Idoso , Agricultura , Animais , Camboja , Criança , Pré-Escolar , Estudos Transversais , Comportamento Alimentar , Feminino , Florestas , Humanos , Lactente , Recém-Nascido , Mosquiteiros Tratados com Inseticida , Malária/parasitologia , Malária/prevenção & controle , Masculino , Pessoa de Meia-Idade , Controle de Mosquitos/instrumentação , Sono , Adulto Jovem
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