RESUMO
Zika virus (ZIKV) is an ongoing global public health emergency with 70 countries and territories reporting evidence of ZIKV transmission since 2015. On 27 August 2016, Singapore reported its first case of local ZIKV transmission and identified an ongoing cluster. Here, we report the genome sequences of ZIKV strains from two cases and find through phylogenetic analysis that these strains form an earlier branch distinct from the recent large outbreak in the Americas.
Assuntos
Surtos de Doenças , Dados de Sequência Molecular , RNA Viral/genética , Zika virus/classificação , Zika virus/isolamento & purificação , Sudeste Asiático/epidemiologia , Análise por Conglomerados , Genótipo , Humanos , Epidemiologia Molecular , Filogenia , Filogeografia , Saúde Pública , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Análise de Sequência de DNA , Singapura , Zika virus/genética , Infecção por Zika virus/transmissão , Infecção por Zika virus/virologiaRESUMO
As the 2009 (H1N1) influenza A virus continues evolving, most mutations appear geographically and temporally confined. However, the latest surveillance data suggests emergence of a new prominent mutation, E391K, in the hemagglutinin (HA) that is globally on the rise. Interestingly, when modelled in the context of the available HA crystal structure, this mutation could alter salt bridge patterns and stability in a region of the HA oligomerization interface that is important for membrane fusion and also a known antigenic site. We discuss occurrence of HA-E391K in global surveillance data and associated clinical phenotypes from Singapore ranging from mostly mild to few severe symptoms, including sporadic vaccine failure. More clinical and experimental data are needed to determine if this mutation could alter the biology and fitness of the virus or if its increased occurrence is due to founder effects.
