Toward Detection of the Molecular Parity Violation in Chiral Ru(acac)3 and Os(acac)3.

We present a theory-experiment investigation of the helically chiral compounds Ru(acac)3 and Os(acac)3 as candidates for next-generation experiments for detection of molecular parity violation (PV) in vibrational spectra. We used relativistic density functional theory calculations to identify optimal vibrational modes with expected PV effects exceeding by up to 2 orders of magnitude the projected instrumental sensitivity of the ultrahigh resolution experiment under construction at the Laboratoire de Physique des Lasers in Paris. Preliminary measurements of the vibrational spectrum of Ru(acac)3 carried out as the first steps toward the planned experiment are presented.

Systematic study and uncertainty evaluation of P, T-odd molecular enhancement factors in BaF.

A measurement of the magnitude of the electric dipole moment of the electron (eEDM) larger than that predicted by the Standard Model (SM) of particle physics is expected to have a huge impact on the search for physics beyond the SM. Polar diatomic molecules containing heavy elements experience enhanced sensitivity to parity (P) and time-reversal (T)-violating phenomena, such as the eEDM and the scalar-pseudoscalar (S-PS) interaction between the nucleons and the electrons, and are thus promising candidates for measurements. The NL-eEDM collaboration is preparing an experiment to measure the eEDM and S-PS interaction in a slow beam of cold BaF molecules [P. Aggarwal et al., Eur. Phys. J. D 72, 197 (2018)]. Accurate knowledge of the electronic structure parameters, Wd and Ws, connecting the eEDM and the S-PS interaction to the measurable energy shifts is crucial for the interpretation of these measurements. In this work, we use the finite field relativistic coupled cluster approach to calculate the Wd and Ws parameters in the ground state of the BaF molecule. Special attention was paid to providing a reliable theoretical uncertainty estimate based on investigations of the basis set, electron correlation, relativistic effects, and geometry. Our recommended values of the two parameters, including conservative uncertainty estimates, are 3.13 ±0.12×1024Hzecm for Wd and 8.29 ± 0.12 kHz for Ws.

Quantum chemical topology at the spin-orbit configuration interaction level: Application to astatine compounds.

We report a methodology that allows the investigation of the consequences of the spin-orbit coupling by means of the QTAIM and ELF topological analyses performed on top of relativistic and multiconfigurational wave functions. In practice, it relies on the "state-specific" natural orbitals (NOs; expressed in a Cartesian Gaussian-type orbital basis) and their occupation numbers (ONs) for the quantum state of interest, arising from a spin-orbit configuration interaction calculation. The ground states of astatine diatomic molecules (AtX with X = AtF) and trihalide anions (IAtI- , BrAtBr- , and IAtBr- ) are studied, at exact two-component relativistic coupled cluster geometries, revealing unusual topological properties as well as a significant role of the spin-orbit coupling on these. In essence, the presented methodology can also be applied to the ground and/or excited states of any compound, with controlled validity up to including elements with active 5d, 6p, and/or 5f shells, and potential limitations starting with active 6d, 7p, and/or 6f shells bearing strong spin-orbit couplings.

Hyperfine Structure Constants on the Relativistic Coupled Cluster Level with Associated Uncertainties.

Accurate predictions of hyperfine structure (HFS) constants are important in many areas of chemistry and physics, from the determination of nuclear electric and magnetic moments to benchmarking of new theoretical methods. We present a detailed investigation of the performance of the relativistic coupled cluster method for calculating HFS constants within the finite-field scheme. The two selected test systems are 133Cs and 137BaF. Special attention has been paid to construct a theoretical uncertainty estimate based on investigations on basis set, electron correlation and relativistic effects. The largest contribution to the uncertainty estimate comes from higher order correlation contributions. Our conservative uncertainty estimate for the calculated HFS constants is ∼5.5%, while the actual deviation of our results from experimental values is <1% in all cases.

Noniterative Doubles Corrections to the Random Phase and Higher Random Phase Approximations: Singlet and Triplet Excitation Energies.

The second-order noniterative doubles-corrected random phase approximation (RPA) method has been extended to triplet excitation energies and the doubles-corrected higher RPA method as well as a shifted version for calculating singlet and triplet excitation energies are presented here for the first time. A benchmark set consisting of 20 molecules with a total of 117 singlet and 71 triplet excited states has been used to test the performance of the new methods by comparison with previous results obtained with the second-order polarization propagator approximation (SOPPA) and the third order approximate coupled cluster singles, doubles and triples model CC3. In general, the second-order doubles corrections to RPA and HRPA significantly reduce both the mean deviation as well as the standard deviation of the errors compared to the CC3 results. The accuracy of the new methods approaches the accuracy of the SOPPA method while using only 10-60% of the calculation time. © 2019 The Authors. Journal of Computational Chemistry published by Wiley Periodicals, Inc.

RPA(D) and HRPA(D): Two new models for calculations of NMR indirect nuclear spin-spin coupling constants.

In this article, the RPA(D) and HRPA(D) models for the calculation of linear response functions are presented. The performance of the new RPA(D) and HRPA(D) models is compared to the performance of the established RPA, HRPA, and SOPPA models in calculations of indirect nuclear spin-spin coupling constants using the CCSD model as a reference. The doubles correction offers a significant improvement on both the RPA and HRPA models; however, the improvement is more dramatic in the case of the RPA model. For all coupling types investigated in this study, the results obtained using the HRPA(D) model are comparable in accuracy to those given by the SOPPA model, while requiring between 30% and 90% of the calculation time needed for SOPPA. The RPA(D) model, while of slightly lower accuracy compared to the CCSD model than HRPA(D), offered calculation times of only approximately 25% of those required for SOPPA for all the investigated molecules. © 2018 Wiley Periodicals, Inc.

Can the Dielectric Constant of Fullerene Derivatives Be Enhanced by Side-Chain Manipulation? A Predictive First-Principles Computational Study.

The low efficiency of organic photovoltaic (OPV) devices has often been attributed to the strong Coulombic interactions between the electron and hole, impeding the charge separation process. Recently, it has been argued that by increasing the dielectric constant of materials used in OPVs, this strong interaction could be screened. In this work, we report the application of periodic density functional theory together with the coupled perturbed Kohn-Sham method to calculate the electronic contribution to the dielectric constant for fullerene C60 derivatives, a ubiquitous class of molecules in the field of OPVs. The results show good agreement with experimental data when available and also reveal an important undesirable outcome when manipulating the side chain to maximize the static dielectric constant: in all cases, the electronic contribution to the dielectric constant decreases as the side chain increases in size. This information should encourage both theoreticians and experimentalists to further investigate the relevance of contributions to the dielectric constant from slower processes like vibrations and dipolar reorientations for facilitating the charge separation, because electronically, enlarging the side chain of conventional fullerene derivatives only lowers the dielectric constant, and consequently, their electronic dielectric constant is upper bound by the one of C60.

Relativistic DFT Calculations of Hyperfine Coupling Constants in 5d Hexafluorido Complexes: [ReF6 ]2- and [IrF6 ]2.

The performance of relativistic density functional theory (DFT) methods has been investigated for the calculation of the recently measured hyperfine coupling constants of hexafluorido complexes [ReF6 ]2- and [IrF6 ]2- . Three relativistic methods were employed at the DFT level of theory: the 2-component zeroth-order regular approximation (ZORA) method, in which the spin-orbit coupling was treated either variationally (EV ZORA) or as a perturbation (LR ZORA), and the 4-component Dirac-Kohn-Sham (DKS) method. The dependence of the results on the basis set and the choice of exchange-correlation functional was studied. Furthermore, the effect of varying the amount of Hartree-Fock exchange in the hybrid functionals was investigated. The LR ZORA and DKS methods combined with DFT led to very similar deviations (about 20 %) from the experimental values for the coupling constant of complex [ReF6 ]2- by using hybrid functionals. However, none of the methods were able to reproduce the large anisotropy of the hyperfine coupling tensor of complex [ReF6 ]2- . For [IrF6 ]2- , the EV ZORA and DKS methods reproduced the experimental tensor components with deviations of ≈10 and ≈5 % for the hybrid functionals, whereas the LR ZORA method predicted the coupling constant to be around one order of magnitude too large owing to the combination of large spin-orbit coupling and very low excitation energies.

El bloqueo ecoguiado del nervio safeno resulta efectivo para la analgesia perioperatoria en los procedimientos ambulatorios artroscópicos realizados en el compartimento interno de la rodilla / Ultrasound-guided saphenous nerve block is an effective technique for perioperative analgesia in ambulatory arthroscopic surgery of the internal knee compartment

Objetivos. La cirugía artroscópica de rodilla es una técnica mínimamente invasiva con un dolor moderado durante las primeras 24 h. Nuestro objetivo principal ha sido determinar el valor del bloqueo ecoguiado del nervio safeno como método de control analgésico intraoperatorio y postoperatorio inmediato. Material y métodos. Estudio observacional y prospectivo. Todos los pacientes recibieron anestesia general con mascarilla laríngea. En el grupo de bloqueo safeno se realizó el bloqueo con 10 ml de ropivacaína al 0,475%. Se determinó la localización de la cirugía (grupo compartimento externo/grupo compartimento interno), el consumo de morfina, la EVA a los 5, 30, 60 y 120 min después de la cirugía y a las 24 h, la necesidad de fármaco de rescate, la aparición de náuseas y vómitos, el tiempo de estancia en la URPA, el retraso en el alta y el grado de satisfacción. Resultados. Se incluyeron 73 pacientes; en 46 la cirugía fue realizada con bloqueo safeno y en 27 sin bloqueo. El consumo de morfina intraoperatorio, postoperatorio y total fue significativamente menor en el grupo safeno, así como la EVA a las 24 h. En el subgrupo de cirugía de compartimento interno se mantuvieron las diferencias en la EVA 24 h, el consumo de morfina y el tiempo de estancia en la URPA. Conclusiones. El bloqueo ecoguiado del nervio safeno, especialmente en la cirugía artroscópica del compartimento interno de la rodilla, disminuye los requerimientos analgésicos obteniendo una mejor calidad en el control del dolor, mayoritariamente a las 24 h de la realización de la cirugía y sin ningún efecto secundario (AU)

Objectives. Arthroscopic knee surgery is a minimally invasive technique with moderate pain during the first 24 h. Our main objective was to evaluate the efficacy of ultrasound guided saphenous nerve block as a method of pain control intraoperatively and postoperatively for this surgery. Material and methods. A prospective and observational study. All patients received general anesthesia with laryngeal mask in the saphenous group, nerve block was performed with 10 ml ropivacaine 0.475%. Location of the surgery (external compartment group/internal compartment group), morphine consumption, VAS for pain at 5, 30, 60 and 120 min and 24 h after surgery, need for rescue medication, onset of nausea and vomiting, length of stay in PACU, delayed discharge and satisfaction were evaluated. Results. The study included 73 patients. Of these, 46 received saphenous nerve block and 27 didn’t receive it. Consumption of intraoperative, postoperative and total morphine was significantly lower in the saphenous group as well as VAS at 24 h. In the subgroup of internal compartment surgery differences in VAS 24 h, morphine consume and lenght of stay in PACU were mantained. Conclusions. The ultrasound-guided block of saphenous nerve, particularly in the internal compartment arthroscopic knee surgery, decreases analgesic requirements, obtaining more effective pain control in the first 24 h postoperatively and without any known side effects (AU)

Ultrasound-guided saphenous nerve block is an effective technique for perioperative analgesia in ambulatory arthroscopic surgery of the internal knee compartment.

OBJECTIVES: Arthroscopic knee surgery is a minimally invasive technique with moderate pain during the first 24h. Our main objective was to evaluate the efficacy of ultrasound guided saphenous nerve block as a method of pain control intraoperatively and postoperatively for this surgery. MATERIAL AND METHODS: A prospective and observational study. All patients received general anesthesia with laryngeal mask in the saphenous group, nerve block was performed with 10 ml ropivacaine 0.475%. Location of the surgery (external compartment group/internal compartment group), morphine consumption, VAS for pain at 5, 30, 60 and 120 min and 24 h after surgery, need for rescue medication, onset of nausea and vomiting, length of stay in PACU, delayed discharge and satisfaction were evaluated. RESULTS: The study included 73 patients. Of these, 46 received saphenous nerve block and 27 didn't receive it. Consumption of intraoperative, postoperative and total morphine was significantly lower in the saphenous group as well as VAS at 24h. In the subgroup of internal compartment surgery differences in VAS 24 h, morphine consume and lenght of stay in PACU were mantained. CONCLUSIONS: The ultrasound-guided block of saphenous nerve, particularly in the internal compartment arthroscopic knee surgery, decreases analgesic requirements, obtaining more effective pain control in the first 24 h postoperatively and without any known side effects.

Complicaciones neurológicas asociadas a bloqueos interescalénico y supraclavicular guiados con ecografía en cirugía electiva de hombro y extremidad superior. Estudio observacional prospectivo en un hospital universitario / Neurological complications associated with ultrasound-guided interscalene and supraclavicular block in elective surgery of the shoulder and arm. Prospective observational study in a university hospital

Objetivos. La incidencia de síntomas neurológicos postoperatorios tras la realización de bloqueo interescalénico varía entre un 4 y un 16%. La mayoría de los casos se resuelven de forma espontánea antes de un año, pero algunos pacientes mantienen sus síntomas de forma permanente. Nuestro objetivo fue valorar la incidencia de síntomas neurológicos postoperatorios tras la realización de los bloqueos anestésicos ecoguiados interescalénico y supraclavicular. Material y métodos. Estudio prospectivo, observacional. Se incluyeron, de forma consecutiva, pacientes sometidos a cirugía de extremidad superior en un hospital universitario, en los que se realizó un bloqueo interescalénico o supraclavicular como técnica aislada o con anestesia general. Siete días después de la intervención se realizó una entrevista telefónica enfocada a la detección de síntomas neurológicos en la extremidad intervenida. En los pacientes con síntomas se realizaron nuevas entrevistas seriadas (al cabo de uno, 3 y 6 meses, y al año de la intervención) hasta la resolución de la sintomatología. A aquellos pacientes con persistencia de sintomatología al cabo de un año se les ofreció la posibilidad de evaluación neurológica. Resultados. Fueron incluidos 121 pacientes, en los que se realizaron 96 bloqueos interescalénicos y 22 bloqueos supraclaviculares. Un 9,9% (IC 95% 5-15%) de los pacientes presentaron algún síntoma neurológico postoperatorio durante la primera semana. No hubo diferencias significativas entre el bloqueo interescalénico (9%) y el supraclavicular (14%). A los 3 meses los síntomas se mantuvieron en 9 pacientes (7,4%), permaneciendo en 4 de ellos (3,3%) la sintomatología al cabo de 1,5 años. Se realizó electromiograma en 3 de ellos, con resultado positivo para lesión nerviosa en todos ellos. Conclusiones. Observamos una elevada incidencia de síntomas neurológicos postoperatorios, así como un preocupante porcentaje de permanencia de la sintomatología. No se evidenciaron diferencias relevantes en la incidencia según el tipo de bloqueo, y tampoco se identificó ninguna característica del paciente o del procedimiento anestésico que estuvieran asociadas con la incidencia de dichos síntomas, salvo una relación marginal con la edad. Basados en estos resultados, es imprescindible la explicación detallada de esta complicación a los pacientes antes de realizar estos bloqueos(AU)

Objectives. The incidence of postoperative neurological symptoms after performing interscalene block varies between 4 and 16%. The majority of cases are resolved spontaneously within a year, but some patients have their symptoms permanently. Our objective was to assess the incidence of postoperative neurological symptoms after performing the ultrasound-assisted interscalene and supraclavicular anaesthetic blocks. Material and methods. A prospective and observational study was conducted on consecutive patients who had undergone upper extremity surgery with an interscalene or supraclavicular block as an isolated technique, or as a complement to general anaesthesia. Seven days after the intervention, a telephone interview was conducted that focused on the detection of neurological symptoms in the operated limb. Further serial interviews were conducted on patients with symptoms (after the first, the third and the sixth month, and one year after surgery) until resolution of symptoms. Neurological evaluation was offered to those patients with persistent symptoms after one year. Results. A total of 121 patients were included, on whom 96 interscalene blocks and 22 supraclavicular blocks were performed. Postoperative neurological symptoms were detected in 9.9% (95% CI , 5-15%) of patients during the first week. No significant differences were observed between interscalene (9%) and supraclavicular block (14%). After 3 months the symptoms persisted in 9 patients (7.4%), with symptoms remaining in 4 patients (3.3%) after 1.5 years. Electromyogram was performed on 3 patients who tested positive for nerve damage. Conclusions. A high incidence of postoperative neurological symptoms was observed, and a worrying percentage of permanence of them. There were no significant differences in incidence according to the type of block, or any features of the patient or the anaesthesia technique that were associated with the incidence of these symptoms, except a marginal relationship with age. These complications must be clearly explained to the patients before performing these blocks(AU)

[Neurological complications associated with ultrasound-guided interscalene and supraclavicular block in elective surgery of the shoulder and arm. Prospective observational study in a university hospital]. / Complicaciones neurológicas asociadas a bloqueos interescalénico y supraclavicular guiados con ecografía en cirugía electiva de hombro y extremidad superior. Estudio observacional prospectivo en un hospital universitario.

OBJECTIVES: The incidence of postoperative neurological symptoms after performing interscalene block varies between 4 and 16%. The majority of cases are resolved spontaneously within a year, but some patients have their symptoms permanently. Our objective was to assess the incidence of postoperative neurological symptoms after performing the ultrasound-assisted interscalene and supraclavicular anaesthetic blocks. MATERIAL AND METHODS: A prospective and observational study was conducted on consecutive patients who had undergone upper extremity surgery with an interscalene or supraclavicular block as an isolated technique, or as a complement to general anaesthesia. Seven days after the intervention, a telephone interview was conducted that focused on the detection of neurological symptoms in the operated limb. Further serial interviews were conducted on patients with symptoms (after the first, the third and the sixth month, and one year after surgery) until resolution of symptoms. Neurological evaluation was offered to those patients with persistent symptoms after one year. RESULTS: A total of 121 patients were included, on whom 96 interscalene blocks and 22 supraclavicular blocks were performed. Postoperative neurological symptoms were detected in 9.9% (95% CI, 5-15%) of patients during the first week. No significant differences were observed between interscalene (9%) and supraclavicular block (14%). After 3 months the symptoms persisted in 9 patients (7.4%), with symptoms remaining in 4 patients (3.3%) after 1.5 years. Electromyogram was performed on 3 patients who tested positive for nerve damage. CONCLUSIONS: A high incidence of postoperative neurological symptoms was observed, and a worrying percentage of permanence of them. There were no significant differences in incidence according to the type of block, or any features of the patient or the anaesthesia technique that were associated with the incidence of these symptoms, except a marginal relationship with age. These complications must be clearly explained to the patients before performing these blocks.

[Perioperative mortality: retrospective cross-sectional study of surgical patients who died between 2004 and 2008 in a tertiary care hospital]. / Mortalidad perioperatoria de los pacientes quirúrgicos: estudio transversal retrospectivo de los pacientes fallecidos en el periodo 2004 a 2008 en un hospital terciario.

OBJECTIVE: Retrospective analysis of all surgical, early postoperative, and 1-week to detect risk factors. MATERIAL AND METHODS: A database was established to record clinical, anesthetic, and surgical variables, grouped as preoperative, intraoperative and postoperative factors, and reflecting comorbidities and postoperative complications. Each patient's cause of death was also recorded. Factors influencing mortality during surgery, at 48 hours, and at 1 week were explored by comparing frequencies to detect correlations. RESULTS: From 2004 to 2008, a total of 809 deaths occurred in the 82412 hospitalized surgical patients. Patients who died during surgery or within 48 hours were younger, had a higher ASA physical status classification, had more cardiovascular risk factors, were less likely to have a diagnosis of cancer, and had spent less time in hospital before the operation. Intraoperative complications, particularly bleeding and cardiac events, were more frequent in patients whose condition was more complex and who died during surgery; that pattern was similar but less marked in patients dying within 48 hours. The patients who died within 48 hours had a higher rate of postoperative hemodynamic complications; the patients who died during the week following surgery had higher rates of septic, neurologic, and respiratory complications. CONCLUSIONS: Emergency surgery stands out as an important predictor of death during or after surgery; other significant risk factors are postoperative complications.

Variables psicológicas como predictores de conductas de prevención relacionadas con la infección por VIH / Psychological variables as predictors of preventive behaviors related to HIV

Objetivo: Estudio transversal que tuvo como su objetivo identificar si variables que incluían a los conocimientos, creencias y motivos se constituían en predictores de dos conductas de prevención relacionadas con la infección por VIH: ½Evitar una relación sexual con penetración¼ e Intención de uso de preservativo en el futuro¼. Métodos: De una muestra original de 648 estudiantes pertenecientes a dos instituciones educativas que se localizan en Hermosillo, México, se trabajó con una submuestra de 328 estudiantes que en el momento del estudio informaron no tener experiencia sexual. Para el analisis de los datos se utilizaron estadísticas descriptivas, el x2 de Pearson y un analisis multivariado de regresión logística. Resultados: El anßlisis con el x2 de Pearson arrojó diferencias significativas en ambas conductas: para los que habían tenido oportunidad de comprometerse en una relación sexual con penetración y la habían evitado (x2 [2]=45.378; p=0.000), así como entre quienes respondieron a una baja o una alta probabilidad de usar preservativo en el futuro (x2 [2]=235.622; p=0.000). El analisis de regresión logística reveló que la variable motivos predijo la conducta evitar una relación sexual con penetración (x22 [9]=33.805; p=0.000), mientras que también la variable motivos predijo la conducta intención de uso de preservativo en el futuro (x2 [8]=18.069; p=0.021).Conclusiones: Se discute la importancia que reviste la variable motivos en el contexto de los programas dirigidos a prevenir la infección por VIH en ese sector de la población.

Fundament: A cross-sectional study was carried out with the main objective to identify if psychological variables including knowledge, belief, and motivation predicted two prevention behaviors related to HIV infection: ½To postpone a sexual intercourse¼ and ½Condom use intention¼. Method: From an original sample of 648 students of two institutions located in Hermosillo, Mexico, we worked with a subsample of 328 students whom reported no sexual experience. For data analysis descriptive statistics, the PearsonÆs x2 and a logistic regression analysis were used. Results: The PearsonÆs x2 showed significant differences in both behaviors: those who have the opportunity to involve in a sexual relationship and they avoid it (x2 [2]=45.378; p=0.000), as well as those who have condom use intention (x2 [2]=235.622; p=0.000). The logistic regression analysis revealed that one type of motivation predicted the behavior to avoid a sexual relationship with penetration (x2 [9]=33.805; p=0.000), if well another type of motivation predicted the behavior condom use intention (x2 [8]=18.069; p=0.021). Conclusions: The role of the variable motivation in the prevention of HIV infection programs is discussed.

Major plasma proteins in pig serum during postnatal development.

The time-course of changes in the levels of albumin, alpha-fetoprotein (AFP), alpha(1)-protease inhibitor (alpha(1)-antitrypsin), alpha(1)-acid glycoprotein, fetuin, haptoglobin, transferrin, IgG and the major acute-phase protein (Pig-MAP) in the blood sera of pigs during the first days and weeks of life was investigated by quantitative radial immunodiffusion. The serum of newborn pigs before suckling was characterised by a very low concentration of total proteins (approximately 25 mg mL(-1)), low levels of albumin and transferrin and the lack of immunoglobulins. In contrast, alpha(1)-acid glycoprotein and fetuin are present at high levels (approximately 12 and 5 mg mL(-1) respectively). The results of the present study show that the piglets undergo a very rapid metabolic maturation with regard to serum proteins, evolving from a characteristic 'fetal' pattern to an 'adult' one. We have paid special attention to the evolution of haptoglobin and Pig-MAP, which are two important acute-phase proteins in pigs. The evolution of serum levels of these proteins suggests that piglets must overcome a moderate acute-phase situation during the first week of life.

Efecto del ozono sobre la activación plaquetaria en pacientes con enfermedades vasculares periféricas: informe preliminar / Effect of the ozone on platelet activation in patients presenting with peripheral vascular diseases: preliminary report

Se verificó en los pacientes con diagnóstico de insuficiencia venosa crónica, con úlceras en miembros inferiores y con isquemia arterial subaguda, a los que se le indicó ozonoterapia por 10 a 20 d, la existencia o no de inhibición de la agregación plaquetaria. La agregación plaquetaria en el plasma rico en plaquetas (200 µL) fue inducida por la adición de concentraciones crecientes de epinefrina (10-8 a 10-5 mol/L) en el medio de incubación y determinada según el método turbidimétrico de Born. La agregación plaquetaria encontrada al inicio del tratamiento con ozono tuvo una media de 38,19 porciento y un rango de 66,25 a 12,5 porciento; mientras que al final del tratamiento disminuyó hasta una media de 14,37 porciento y un rango de 28,75 a 6,25 porciento. Se observó una disminución del porcentaje de agregación plaquetaria al final del tratamiento con ozono, con respecto a los valores iniciales

[Rapidly progressive dementia caused by tumor microembolism in the central nervous system]. / Demencia de evolución rapidamente progresiva producida por microembolias tumorales en el sistema nervioso central.

Brain tumoral microembolism is a very unusual etiology of cerebral vascular disease in patients with cancer. The clinical course is characterized by diffuse encefalopathy with associated neurologic deficits. We report a 72-year-old male patient, who developed rapidly progressive dementia associated with diffuse myoclonic jerks, without neurologic deficit, whose brain biopsy showed microscopic emboli of adenocarcinoma of unknown origin in capillary vessels. We did not find metastasis in other organs. We suggest that this entity should be included in the differential diagnoses of the subacute dementias.

[Acute meningitis caused by Streptococcus agalactiae in adult patient with a spinal fluid fistula]. / Meningitis aguda por Streptococcus agalactiae en una paciente adulta con fístula de líquido cefalorraquídeo.

Acute meningitis in adults caused by Streptococcus agalactiae is a rare entity. To our knowledge, there are only two cases associated with a central spinal fluid fistula published in the English literature from 1942 to the present. We report the third case. It was diagnosed in a 60-year-old woman with a twelve-year history of cerebrospinal rhinorrhea after a blunt head trauma. A CT scan of the base of the skull with administration of intrathecal contrast showed a disruption of the posterior and superior aspect of the sphenoid sinus with central spinal fluid leakage.