RESUMO
BACKGROUND: Recovery from multiple sclerosis (MS) relapses is variable. The factors influencing persistence of residual disability (RD) after a relapse are still to be thoroughly elucidated. AIMS OF STUDY: To assess RD after MS relapses and to define the factors associated with persistence of RD. METHODS: Data were retrospectively collected for all relapses in a population of relapsing-remitting MS patients during 3 years. Relapse severity and RD after 1 year were calculated on Expanded Disability Status Scale basis. A multivariable analysis for factors influencing RD and relapse severity was performed (variables: age, gender, disease duration, oligoclonal bands, relapse severity, monosymptomatic/polysymptomatic relapse, immunomodulating treatment, incomplete recovery at 1 month). RESULTS: A total of 174 relapses were assessed. RD after 1 year was observed in 54.5% of the relapses. Higher risk of RD was associated with occurrence of a severe relapse (P = 0.024). Incomplete recovery at 1 month was highly predictive of RD at 1 year (P < 0.0001). Risk of a severe relapse was associated with age Assuntos
Esclerose Múltipla Recidivante-Remitente/fisiopatologia
, Adolescente
, Adulto
, Fatores Etários
, Avaliação da Deficiência
, Feminino
, Humanos
, Modelos Logísticos
, Masculino
, Pessoa de Meia-Idade
, Modelos Estatísticos
, Esclerose Múltipla Recidivante-Remitente/diagnóstico
, Esclerose Múltipla Recidivante-Remitente/terapia
, Análise Multivariada
, Bandas Oligoclonais/líquido cefalorraquidiano
, Recidiva
, Estudos Retrospectivos
, Fatores de Risco
, Índice de Gravidade de Doença
, Fatores Sexuais
, Adulto Jovem