Assuntos
Imunoglobulinas/análise , Leucemia Linfocítica Crônica de Células B/imunologia , Anticorpos Monoclonais , Anticorpos Antineoplásicos , Linfócitos B/imunologia , Linfócitos B/patologia , Células Clonais/patologia , Citoplasma/análise , Imunofluorescência , Humanos , Proteínas de Neoplasias/análise , Receptores de Antígenos de Linfócitos B/análiseRESUMO
It is generally assumed that chronic lymphocytic leukemia of B cell origin (B-CLL) is characterized by the presence of surface membrane immunoglobulins (SmIg) and by the absence of cytoplasmic immunoglobulins (CyIg). In a variable number of cases SmIg are not detectable because of their low density on the cellular surface. Because a constant presence of CyIg in 20 subjects suffering from B-CLL has been reported recently, we reexamined 15 SmIg-negative and 10 SmIg-positive B-CLL patients by SmIg and CyIg determinations. We used a direct immunofluorescence method on peripheral blood mononuclear cells for the detection of SmIg and, after fixation, for CyIg. CyIg were detectable in 24 out of 25 cases, with a fluorescence intensity ranging from weak to moderate. The existence of frequent negative results for CyIg determination in B-CLL reported in the literature probably depends on the low sensitivity of the method used. We conclude that CyIg determination is useful in phenotyping every B-CLL patient, especially SmIg-negative ones.
Assuntos
Linfócitos B/imunologia , Imunoglobulinas/análise , Leucemia Linfoide/imunologia , Antígenos de Neoplasias/análise , Antígenos de Superfície/análise , Células Clonais , Citoplasma/imunologia , Imunofluorescência , Humanos , Cadeias Pesadas de Imunoglobulinas/análise , Cadeias Leves de Imunoglobulina/análise , Receptores de Antígenos de Linfócitos B/análiseRESUMO
Idiopathic thrombocytopenic purpura (ITP) during pregnancy may cause serious bleeding in the mother and fetus. Therapy with high-dose intravenous immunoglobulins has caused an immediate and predictable rise in platelet count in both adults and children with chronic or acute ITP. We report our experience in managing a woman near term in pregnancy. The patient demonstrated a rapid increase in platelet count, delivered without excessive bleeding and had a normal child with normal platelet count. Intravenous immunoglobulins may offer a new and safe way to control maternal and fetal platelet counts during pregnancy, delivery and neonatal period.
Assuntos
Imunização Passiva , Imunoglobulina G/administração & dosagem , Complicações Hematológicas na Gravidez/tratamento farmacológico , Púrpura Trombocitopênica/tratamento farmacológico , Esteroides/uso terapêutico , Adulto , Plaquetas/efeitos dos fármacos , Resistência a Medicamentos , Feminino , Humanos , Imunoglobulinas Intravenosas , Injeções Intravenosas , Contagem de Plaquetas , Gravidez , Complicações Hematológicas na Gravidez/etiologia , Púrpura Trombocitopênica/etiologiaAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Doença de Hodgkin/terapia , Linfoma não Hodgkin/etiologia , Neoplasias Induzidas por Radiação/etiologia , Radioterapia/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/radioterapia , Humanos , Linfoma não Hodgkin/induzido quimicamente , Masculino , Mecloretamina/administração & dosagem , Mecloretamina/efeitos adversos , Pessoa de Meia-Idade , Prednisona/administração & dosagem , Prednisona/efeitos adversos , Procarbazina/administração & dosagem , Procarbazina/efeitos adversos , Vincristina/administração & dosagem , Vincristina/efeitos adversosRESUMO
The role of splenectomy in the treatment of hairy cell leukemia (HCL) is now well established. There are however some particular situations which indicate splenectomy as a possible emergency therapy in markedly cytopenic cases with severe antibiotic-resistant infections. The aim of the emergency splenectomy in such conditions is to temporarily increase neutrophils and to permit the improvement of the infectious disease. We describe 2 cases of HCL with severe infectious disease, successfully splenectomized.
