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Sci Rep ; 10(1): 6301, 2020 04 14.
Artigo em Inglês | MEDLINE | ID: mdl-32286449

RESUMO

Gadolinium-based contrast agents (GBCAs) are frequently used in patients undergoing magnetic resonance imaging. In GBCAs gadolinium (Gd) is present in a bound chelated form. Gadolinium is a rare-earth element, which is normally not present in human body. Though the blood elimination half-life of contrast agents is about 90 minutes, recent studies demonstrated that some tissues retain gadolinium, which might further pose a health threat due to toxic effects of free gadolinium. It is known that the bone tissue can serve as a gadolinium depot, but so far only bulk measurements were performed. Here we present a summary of experiments in which for the first time we mapped gadolinium in bone biopsy from a male patient with idiopathic osteoporosis (without indication of renal impairment), who received MRI 8 months prior to biopsy. In our studies performed by means of synchrotron radiation induced micro- and submicro-X-ray fluorescence spectroscopy (SR-XRF), gadolinium was detected in human cortical bone tissue. The distribution of gadolinium displays a specific accumulation pattern. Correlation of elemental maps obtained at ANKA synchrotron with qBEI images (quantitative backscattered electron imaging) allowed assignment of Gd structures to the histological bone structures. Follow-up beamtimes at ESRF and Diamond Light Source using submicro-SR-XRF allowed resolving thin Gd structures in cortical bone, as well as correlating them with calcium and zinc.


Assuntos
Meios de Contraste/análise , Osso Cortical/diagnóstico por imagem , Gadolínio/análise , Biópsia , Meios de Contraste/administração & dosagem , Meios de Contraste/farmacocinética , Osso Cortical/química , Osso Cortical/patologia , Osso Cortical/ultraestrutura , Gadolínio/administração & dosagem , Gadolínio/isolamento & purificação , Gadolínio/farmacocinética , Meia-Vida , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Osteoporose/diagnóstico por imagem , Espectrometria por Raios X/instrumentação , Síncrotrons , Fatores de Tempo , Distribuição Tecidual
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