1.
Bioorg Med Chem Lett
; 20(5): 1661-4, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20138514
RESUMO
A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3beta was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.