The Icing on the Cake. Or Is it Frosting? The Influence of Group Membership on Children's Lexical Choices.

Adults are skilled at using language to construct/negotiate identity and to signal affiliation with others, but little is known about how these abilities develop in children. Clearly, children mirror statistical patterns in their local environment (e.g., Canadian children using zed instead of zee), but do they flexibly adapt their linguistic choices on the fly in response to the choices of different peers? To address this question, we examined the effect of group membership on 7- to 9-year-olds' labeling of objects in a trivia game, exploring whether they were more likely to use a particular label (e.g., sofa vs. couch) if members of their "team" also used that label. In a preregistered study, children (N = 72) were assigned to a team (red or green) and were asked during experimental trials to answer questions-which had multiple possible answers (e.g., blackboard or chalkboard)-after hearing two teammates and two opponents respond to the same question. Results showed that children were significantly more likely to produce labels less commonly used by the community (i.e., dispreferred labels) when their teammates had produced those labels. Crucially, this effect was tied to group membership, and could not be explained by children simply repeating the most recently used label. These findings demonstrate how social processes (i.e., group membership) can guide linguistic variation in children.

Infants' and toddlers' language development during the pandemic: Socioeconomic status mattered.

The disruption caused by the COVID-19 pandemic has raised concerns about children's development. Here, we examined the impact of the pandemic on Canadian infants' and toddlers' (N = 539) language development. Specifically, we assessed changes in 11- to 34-month-olds' activities that are known to affect vocabulary development (i.e., screen and reading times). We also compared these children's vocabulary sizes with those of 1365 children collected before the pandemic using standardized vocabulary assessments. Our results show that screen and reading times were most negatively affected in lower-income children. For vocabulary growth, no measurable change was detected in middle- and high-income children, but lower-income 19- to 29-month-olds fared worse during the pandemic than during pre-pandemic times. Moving forward, these data indicate that educators and policymakers should pay particular attention to children from families with lower socioeconomic status during times of crisis and stress.

Self-assembly of achiral building blocks into chiral cyclophanes using non-directional interactions.

The diastereoselective assembly of achiral constituents through a single spontaneous process into complex covalent architectures bearing multiple stereogenic elements still remains a challenge for synthetic chemists. Here, we show that such an extreme level of control can be achieved by implementing stereo-electronic information on synthetic organic building blocks and templates and that non-directional interactions (i.e., electrostatic and steric interactions) can transfer this information to deliver, after self-assembly, high-molecular weight macrocyclic species carrying up to 16 stereogenic elements. Beyond the field of supramolecular chemistry, this proof of concept should stimulate the on-demand production of highly structured polyfunctional architectures.

[Use of heparin calibrated anti-Xa assay for apixaban and rivaroxaban measurement in the context of regional telestroke activity]. / Estimation de la concentration en apixaban et en rivaroxaban par l'activité anti-Xa héparine en contexte d'activité régionale de télé-AVC.

INTRODUCTION: In Bordeaux University Hospital, neurologists are required to prescribe thrombolysis using telemedicine (telethrombolysis) for anticoagulated stroke patients admitted in peripheral centers in the Nouvelle-Aquitaine region. However, due to the bleeding risk, the maximum concentration of DOAC authorizing thrombolysis is 30, 50 or 100 ng/mL (depending on the sources and the patient-specific benefit-risk ratio). Most of the time, specific assays of Direct Oral Anticoagulants (DOACs) are not available in these peripheral centers. We therefore studied an alternative test: the Unfractionated Heparin (UFH) anti-Xa activity which is available in most laboratories and could be used to estimate the DOAC concentration. METHODS: Five centers were included in our study: three centers using the Liquid Anti-Xa HemosIL® Werfen reagent and two centers using the STA-Liquid Anti-Xa® Stago reagent. For each reagent, we established correlation curves between DOAC and UFH anti-Xa activities and determinated UFH cut-offs for the thresholds of 30, 50 and 100 ng/mL respectively. RESULTS: A total of 1455 plasmas were tested. There is an excellent correlation between DOAC and UFH anti-Xa activities using a third-degree modeling curve, independently the reagent used. However, a significant inter-reagent variability is observed concerning the obtained cut-offs. CONCLUSION: Our study makes unsuitable the use of a universal cut-off. In opposition to recommendations made by other publications, the UFH cut-offs must be adapted to the reagent used locally by the laboratory, and to the considered DOAC.

Fluid-Mediated Fabrication of Complex Assemblies.

This Perspective accounts for recent progress in the directed control of interfacial fluid flows harnessed to assemble architected soft materials. We are focusing on the paradigmatic problem of free-surface flows in curable elastomers. These elastomers are initially liquid and cure into elastic solids whose shape is imparted by concomitant and competing phenomena: flow-induced deformations and curing. Particular attention is given to the role of capillary forces in these systems. Originating from the cohesive nature of liquids and thus favoring smooth interfaces, capillary forces can also promote the destabilization of interfaces, e.g., into droplets. In turn, such mechanical instabilities tend to grow into regular patterns, e.g., forming hexagonal lattices. We discuss how the universality, robustness, and ultimate regularity of these out-of-equilibrium processes could serve as a basis for new fabrication paradigms, where instabilities are directed to generate target architected solids obtained without each element laid in place by direct mechanized intervention.

Looking for Wugs in all the Right Places: Children's Use of Prepositions in Word Learning.

To help infer the meanings of novel words, children frequently capitalize on their current linguistic knowledge to constrain the hypothesis space. Children's syntactic knowledge of function words has been shown to be especially useful in helping to infer the meanings of novel words, with most previous research focusing on how children use preceding determiners and pronouns/auxiliary to infer whether a novel word refers to an entity or an action, respectively. In the current visual world experiment, we examined whether 28- to 32-month-olds could exploit their lexical semantic knowledge of an additional class of function words-prepositions-to learn novel nouns. During the experiment, children were tested on their ability to use the prepositions in, on, under, and next to to identify novel creatures displayed on a screen (e.g., The wug is on the table), as well as their ability to later identify the creature without accompanying prepositions (e.g., Look at the wug). Children overall demonstrated understanding of all the prepositions but next to and were able to use their knowledge of prepositions to learn the associations between novel words and their intended referents, as shown by greater-than chance looks to the target referent when no prepositional phrase was provided.

The impact of the Oakland SSB tax on prices and volume sold: A study of intended and unintended consequences.

We examine the effects of a sugar-sweetened beverage (SSB) tax that took effect in Oakland, California in 2017. Using rich customized universal product code -level data, we estimate the effect of the SSB tax on prices and volume in the short to medium term in a difference-in-differences framework. We pay particular attention to tax-avoidance strategies that may minimize the policy's intended effect including: (i) transfers to SSBs to the nontaxed border area (i.e., cross-border shopping), (ii) a move from high-priced per ounce single serve to their cheaper multipacks or larger format counterparts (i.e., format switching), and (iii) a move from high-priced beverages to less expensive ones within a category and format (i.e., brand switching). We find that the year-over-year tax pass-through is 49%. We find that volume sold of taxed beverages fell by 14%, but 46% of this decrease is offset with an increase in the border area. We also find evidence of substitution to lower-priced taxed beverages but no evidence of switching to cheaper formats. Finally, we find important dynamic effects with respect to tax pass-through, volume sold and cross-border shopping.

The Impact of a Sweetened Beverage Tax on Beverage Volume Sold in Cook County, Illinois, and Its Border Area.

Background: Sugar-sweetened beverage (SSB) consumption is linked to adverse health outcomes. Objective: To evaluate the impact of the 2017 Cook County, Illinois, Sweetened Beverage Tax (SBT) on the volume of taxed and untaxed beverages sold in Cook County and its 2-mile border area. Design: Pre-post intervention-comparison site difference-in-differences study. Setting: Cook County, Illinois, and St. Louis City and County, Missouri, 2016 to 2017. Participants: Universal product code-level store scanner data from supermarkets and grocery, convenience, drug, mass merchandise, and dollar stores. Measurements: Beverage volume sold of taxed and untaxed beverages, across product categories and sizes. Results: Volume sold of taxed beverages decreased by 27% (ratio of incidence rate ratios [RIRR], 0.73 [95% CI, 0.70 to 0.75]) on average in Cook County relative to St. Louis during the 4 months that the SBT was in effect (compared with the same 4-month pretax period), with a net decrease of 21% after increases in volume sold in its border area (cross-border shopping) were taken into account. The magnitude of the decrease in volume sold across types of taxed beverages was heterogeneous: -32% (RIRR, 0.68 [CI, 0.65 to 0.72]) for soda versus -11% (RIRR, 0.89 [CI, 0.82 to 0.97]) for energy drinks, -37% (RIRR, 0.63 [CI, 0.59 to 0.66]) for artificially sweetened beverages versus -25% (RIRR, 0.75 [CI, 0.72 to 0.79]) for SSBs, and -29% (RIRR, 0.71 [CI, 0.68 to 0.74]) for family-size versus -19% (RIRR, 0.81 [CI, 0.79 to 0.84]) for individual-size beverages. There was no significant change in volume sold of untaxed beverages in Cook County or its border area. Limitation: Data source did not allow for evaluation by store type or distance of outlets from the border. Conclusion: The Cook County SBT led to a substantial reduction in the volume sold of taxed beverages in Cook County. Part of this effect was offset by cross-border shopping. Cross-border shopping was limited to tax avoidance and did not extend to untaxed beverages. Primary Funding Source: Bloomberg Philanthropies.

The impact of the Cook County, IL, Sweetened Beverage Tax on beverage prices.

This study assessed the extent to which the Cook County, IL, Sweetened Beverage Tax (SBT) of one cent per ounce (oz) on sugar-sweetened and artificially sweetened beverages was passed on to consumers in the form of higher prices. We drew on universal product code-level store scanner data and used a pre-post intervention-comparison site difference-in-differences (DID) study design to estimate the impact of the Cook County SBT on prices of taxed beverages, across product categories and sizes, as well as on prices of untaxed beverages. The DID model results showed an over-shifting of the tax with a 119% pass-through rate, on average, across all taxed beverages in Cook County compared to its comparison site. This price change represented, on average, a 34% increase in prices of taxed beverages. For untaxed beverages, prices were estimated to increase slightly by 0.04 cents per oz driven mainly by an increase in milk prices (0.12 cents per oz). We also found some heterogeneity in tax pass-through for the taxed beverages by sweetened beverage product category and size with pass-through being higher, on average, for individual-size (126%) compared to family-size (117%) beverages and higher for energy drinks (145%) compared to other sweetened beverages. Based on the baseline prices of different categories and sizes of beverages, the effective percentage increase in beverage prices resulting from the Cook County SBT ranged from a 52% increase for family-size soda to a 10% increase for family-size energy drinks.

Density measurement of liquid 22MnB5 by aerodynamic levitation.

This study is part of the general context of thermophysical characterization of liquid metals with an aerodynamic levitation device and laser heating. The density measurements vs temperature of pure and alloyed metals are determined during cooling of the sample. The temperature and shape of the sample are measured, respectively, with a bichromatic pyrometer and filmed by a high-speed camera. The sample visualization is performed by backlighting, which has been preferred to self-illumination. The post-treatment process consists in a binarisation of each recorded image, and then, an ellipse is fitted on the detected edge. The density is directly calculated with the ellipse volume and the sample weight. The good agreement of experimental results on pure metals with the literature validates the method. Then, an industrial steel of unknown liquid density is characterized from 1750 K to 2250 K.

Dynamics of Liquid Transfer from Nanoporous Stamps in High-Resolution Flexographic Printing.

Printing of ultrathin layers of polymeric and colloidal inks is critical for the manufacturing of electronics on nonconventional substrates such as paper and polymer films. Recently, we found that nanoporous stamps overcome key limitations of traditional polymer stamps in flexographic printing, namely, enabling the printing of ultrathin nanoparticle films with micron-scale lateral precision. Here, we study the dynamics of liquid transfer between nanoporous stamps and solid substrates. The stamps comprise forests of polymer-coated carbon nanotubes, and the surface mechanics and wettability of the stamps are engineered to imbibe colloidal inks and transfer the ink upon contact with the target substrate. By high-speed imaging during printing, we observe the dynamics of liquid spreading, which is mediated by progressing contact between the nanostructured stamp surface and by the substrate and imbibition within the stamp-substrate gap. From the final contact area, the volume of ink transfer is mediated by rupture of a capillary bridge; and, after rupture, liquid spreads to fill the area defined by a precursor film matching the stamp geometry with high precision. Via modeling of the liquid dynamics, and comparison with data, we elucidate the scale- and rate-limiting aspects of the process. Specifically, we find that the printed ink volume and resulting layer thickness are independent of contact pressure; and that printed layer thickness decreases with retraction speed. Under these conditions, nanoparticle films with controlled thickness in the <100 nm regime can be printed using nanoporous stamp flexography, at speeds commensurate with industrial printing equipment.

On-Demand Cyclophanes: Substituent-Directed Self-Assembling, Folding, and Binding.

A family of p-cyclophanes based on bis- or tetrafunctionalized 1,4-bisthiophenol units linked by disulfide bridges was obtained by self-assembly on a gram scale and without any chromatographic purification. The nature of the functionalities borne by these so-called dyn[4]arenes plays a crucial role on their structural features as well as their molecular recognition abilities. Tuning these functions on demand yields tailored receptors for cations, anions, or zwitterions in organic or aqueous media.

An introduction to the mechanics of the lasso.

Trick roping evolved from humble origins as a cattle-catching tool into a sport that delights audiences all over the world with its complex patterns or 'tricks'. Its fundamental tool is the lasso, formed by passing one end of a rope through a small loop (the honda) at the other end. Here, we study the mechanics of the simplest rope trick, the Flat Loop, in which the rope is driven by the steady circular motion of the roper's hand in a horizontal plane. We first consider the case of a fixed (non-sliding) honda. Noting that the rope's shape is steady in the reference frame rotating with the hand, we analyse a string model in which line tension is balanced by the centrifugal force and the rope's weight. We use numerical continuation to classify the steadily rotating solutions in a bifurcation diagram and analyse their stability. In addition to Flat Loops, we find planar 'coat-hanger' solutions, and whirling modes in which the loop collapses onto itself. Next, we treat the more general case of a honda that can slide due to a finite coefficient of friction of the rope on itself. Using matched asymptotic expansions, we resolve the shape of the rope in the boundary layer near the honda where the rope's bending stiffness cannot be neglected. We use this solution to derive a macroscopic criterion for the sliding of the honda in terms of the microscopic Coulomb static friction criterion. Our predictions agree well with rapid-camera observations of a professional trick roper and with laboratory experiments using a 'robo-cowboy'.

CT scan-guided percutaneous osteosynthesis of a complex, multifocal fracture of the pelvic girdle in a 14-year-old adolescent.

We report on a 14-year-old girl with minimally displaced pelvic girdle and acetabular roof fracture following motor vehicle trauma, treated percutaneously under CT and C-arm fluoroscopic guidance by an interventional radiologist. After informed consent from the patient's parents, under surgical aseptic conditions and under general anesthesia, three screws were positioned adequately under dual guidance by a radiologist and without immediate or long-term complication. The patient was mobilized 48 h after the procedure and resumed normal activities after 1 month. Even though the technique has been described before on adults, to our knowledge this is the first time it has been described on a pediatric patient.

Payment mechanism and GP self-selection: capitation versus fee for service.

This paper analyzes the consequences of allowing gatekeeping general practitioners (GPs) to select their payment mechanism. We model GPs' behavior under the most common payment schemes (capitation and fee for service) and when GPs can select one among them. Our analysis considers GP heterogeneity in terms of both ability and concern for their patients' health. We show that when the costs of wasteful referrals to costly specialized care are relatively high, fee for service payments are optimal to maximize the expected patients' health net of treatment costs. Conversely, when the losses associated with failed referrals of severely ill patients are relatively high, we show that either GPs' self-selection of a payment form or capitation is optimal. Last, we extend our analysis to endogenous effort and to competition among GPs. In both cases, we show that self-selection is never optimal.

Subcomponent self-assembly of rare-earth single-molecule magnets.

A family of lanthanide complexes has been synthesized by the subcomponent self-assembly methodology. Molecular architectures, which were stable in solution and under ambient conditions, were designed by the in situ formation of ligands around lanthanide ion templates. Magnetic studies indicated that, despite the low C2 symmetry, 1 and 2 display single molecule magnet (SMM) behavior, with 1 exhibiting an effective energy barrier of the relaxation of the magnetization U(eff)/k(B) = 50 K and the pre-exponential factor τ(o) = 6.80 × 10(-7) s. Step-like features in the hysteresis loops indicate the presence of quantum tunneling of the magnetization (QTM).

Treatment and referral decisions under different physician payment mechanisms.

This paper analyzes and compares the incentive properties of some common payment mechanisms for GPs, namely fee for service (FFS), capitation and fundholding. It focuses on gatekeeping GPs and it specifically recognizes GPs heterogeneity in both ability and altruism. It also allows inappropriate care by GPs to lead to more serious illnesses. The results are as follows. Capitation is the payment mechanism that induces the most referrals to expensive specialty care. Fundholding may induce almost as much referrals as capitation when the expected costs of GPs care are high relative to those of specialty care. Although driven by financial incentives of different nature, the strategic behaviors associated with fundholding and FFS are very much alike. Finally, whether a regulator should use one or another payment mechanism for GPs will depend on (i) his priorities (either cost-containment or quality enhancement) which, in turn, depend on the expected cost difference between GPs care and specialty care, and (ii) the distribution of profiles (diagnostic ability and altruism levels) among GPs.

Estimating differences between male and female physician service provision using panel data.

Using panel data, we estimate the impact of an increasing share of female physicians on the total output of Canadian physicians. A micro-econometric model is developed specifically for the Canadian context and estimated using administrative data on all Canadian physicians paid on a fee-for-service basis from 1989 to 1998. Our results suggest that female physicians systematically provide fewer services than their male counterparts for almost all specialties and provinces studied. Given that females account for an increasing share of the physician population and that female physicians provide, on average, fewer services, potentially important future reductions in total health-care service provision are likely.

The cost of schizophrenia: lessons from an international comparison.

BACKGROUND: A number of studies have attempted to estimate the aggregate burden of mental illness in particular countries. It has been observed that the economic costs vary by country. This is particularly true for estimates of the cost of schizophrenia, a severe mental illness that can lead to major psychiatric disability. The reasons for this may be due to differences in populations, measurement methods or quality of care. AIMS OF THE STUDY: This paper reviews three key studies of the cost of schizophrenia in Canada, the United States and the United Kingdom with an emphasis on a US-Canada comparison. The detailed focus allows for an in-depth study of the factors that lead to different cost estimates. A secondary aim of this paper is to illustrate the importance of direct and indirect costs in the measurement of economic burden. METHODS: We explore various hypotheses about why three major studies of the economic burden of schizophrenia suggest large differences in the estimated per capita costs when expressed in the same currency. We discuss adjustments that may be made in the reported cost estimates to account for factors such as higher wages or lower administrative costs, in order to make them more comparable. RESULTS: In spite of the many adjustments, the estimated per capita resources spent on care for people with schizophrenia in Canada is less than half of the corresponding amount in the US (1,122 million dollars compared to 2,306 million dollars). Even though adjusting for per capita income narrows the apparent gap between the Canadian and US figures, it still remains very large. Since adjusting for per capita income almost certainly over-adjusts for resources spent in the US as compared to Canada, it is clear that the true difference is very large. Even though the per capita direct costs in Canada are only about a third as large as the corresponding US figure, the UK figure is less than half of Canada's. Coincidentally, if one assumes that the true prevalence rate in the UK is similar to that estimated for Canada and adjusts figures accordingly, the result is an estimate for direct costs that is quite similar to the Canadian one. DISCUSSION AND LIMITATIONS: With respect to direct costs, a key finding in the paper is the very large difference in the per capita cost of treatment of schizophrenia in Canada and the United States. From the standpoint of Canadian public policy, the worrisome policy question that this raises is whether the findings reflect, on average, a relatively less satisfactory level of treatment for those with schizophrenia in Canada. An important limitation is that we do not analyze quality of care data. Our detailed item by item comparison of the estimates attempts to rule out alternative explanations in order to discover whether a quality difference may actually exist. IMPLICATIONS FOR HEALTH POLICIES: This research reviews US and international estimates of the economic burden of schizophrenia. In the process of summarizing what is known, a remarkable difference in the direct cost of schizophrenia is uncovered. Possible methodological and economic explanations are investigated (e.g., adjustments for different financial currencies and study methodologies). Nevertheless, the results appear robust to a variety of sensitivity analyses. From the standpoint of public policy, the worrisome question that this raises is whether these findings reflect, on average, a relatively lower quality of care for Canadians with schizophrenia or wasteful care for Americans with schizophrenia.