1.
Bioorg Med Chem Lett
; 17(14): 3835-9, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17532214
RESUMO
New modifications on the C-8 4-aminobenzyl unit of the previously reported 3-alkyl-1,8-dibenzylxanthine inhibitors of cPEPCK are presented. The most active compound reported here is the 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonic acid amide derivative 2 with an IC(50) of 0.29+/-0.08 microM. An X-ray analysis of a heteroaromatic sulfonamide is presented showing a new pi-pi interaction.
Assuntos
Citosol/enzimologia , Inibidores Enzimáticos/farmacologia , Fosfoenolpiruvato Carboxiquinase (GTP)/antagonistas & inibidores , Xantinas/farmacologia , Inibidores Enzimáticos/química , Humanos , Modelos Moleculares , Xantinas/química
2.
Proteins
; 63(4): 1123-6, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16523484
