RESUMO
The occurrence of chronic tick-borne encephalitis viral antigenemia characterized by the asymptomatic course or minimal clinical manifestations is caused by the virus-immune cell interaction. Cellular immunity was studied in 183 patients with chronic (more than 6-month) tick-borne encephalitis viral antigenemia, by evaluating the immunophenotypic and cytogenetic statuses, structural and functional features, cytokine profile, and peripheral lymphocytic apoptosis. The findings suggest impairments in the cooperation of immunocompetent cells and in the classical scheme of antiviral immunity regulation in tick-borne encephalitis viral persistence due to the changes in lymphocytic structural and functional properties.
Assuntos
Antígenos Virais/sangue , Vírus da Encefalite Transmitidos por Carrapatos/imunologia , Encefalite Transmitida por Carrapatos/imunologia , Apoptose , Células Cultivadas , Doença Crônica , Citocinas/biossíntese , Reparo do DNA , Encefalite Transmitida por Carrapatos/sangue , Humanos , Contagem de Leucócitos , Leucócitos Mononucleares/imunologia , Leucócitos Mononucleares/fisiologia , Leucócitos Mononucleares/efeitos da radiação , Subpopulações de Linfócitos/imunologia , Subpopulações de Linfócitos/fisiologia , Raios UltravioletaRESUMO
Chronic viral hepatitis C is associated with decreased production of TNF-alpha by the peripheral blood mononuclear leukocytes irrespective of virus genotype and degree of the morphological activity of the process in the liver. This process positively correlates with the increase in the content of TNF-alpha soluble receptor (molecular weight 55 kDa), which can play a role in the mechanisms of immunopathogenesis of long persistence of hepatitis C virus in the body.
