[Effect of the catalytic subunit of cAMP-dependent protein kinase on the electrical activity of the rat heart in isadrine myocarditis]. / Vliianie kataliticheskoi sub''edinitsy cAMP-zavisimoi proteinkinazy na élektricheskuiu aktivnost' serdtsa krysy pri izadrinovom miokardite.

The content of cAMP in the rat heart under neoepinephrine myocarditis does not differ from the control values and less increases relative to the control at the adrenalin concentrations of 5 X 10(-5) and 5 X 10(-4) M in the in vitro experiments (control: myocardium of healthy animals). Under these conditions dissociation of holoenzyme of cAMP-dependent protein kinase is disturbed in the presence of endogene-developed nucleotide and the phosphorylating activity decreases, respectively. The injection of the catalytic subunit of cAMP-dependent protein kinase encapsulated into neutral liposomes increases the duration of the myocarditis action potential for animals with the metabolic myocardial insufficiency.